{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T07:50:10Z","timestamp":1744185010899,"version":"3.38.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Therapies"],"published-print":{"date-parts":[[2011,9]]},"DOI":"10.2515\/therapie\/2011051","type":"journal-article","created":{"date-parts":[[2011,10,26]],"date-time":"2011-10-26T13:55:39Z","timestamp":1319637339000},"page":"421-429","source":"Crossref","is-referenced-by-count":5,"title":["Consommation de jus de pamplemousse et risque d\u2019interactions m\u00e9dicamenteuses : \u00e9tude transversale dans un service d\u2019urgences m\u00e9dicales"],"prefix":"10.1016","volume":"66","author":[{"given":"Lucien","family":"Roulet","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Asseray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Line","family":"Mottier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Chiffoleau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilles","family":"Potel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryse","family":"Lapeyre-Mestre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7oise","family":"Ballereau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6","key":"10.2515\/therapie\/2011051_bb0005","first-page":"357","article-title":"Ethanol enhances the hemodynamic effects of felodipine","volume":"12","author":"Bailey","year":"1989","journal-title":"Clin Invest Med"},{"issue":"11","key":"10.2515\/therapie\/2011051_bb0010","first-page":"1228","article-title":"Mechanisms of enhanced oral availability of CYP3A4 substrates by grapefruit constituents. Decreased enterocyte CYP3A4 concentration and mechanism-based inactivation by furanocoumarins","volume":"25","author":"Schmiedlin-Ren","year":"1997","journal-title":"Drug Metab Dispos"},{"issue":"5","key":"10.2515\/therapie\/2011051_bb0015","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/0009-9236(95)90032-2","article-title":"Disposition of intravenous and oral cyclosporine after administration with grapefruit juice","volume":"57","author":"Ducharme","year":"1995","journal-title":"Clin Pharmacol Ther"},{"issue":"2","key":"10.2515\/therapie\/2011051_bb0020","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s002280050263","article-title":"Effects of grapefruit juice ingestionpharmacokinetics and haemodynamics of intravenously and orally administered felodipine in healthy men","volume":"52","author":"Lundahl","year":"1997","journal-title":"Eur J Clin Pharmacol"},{"issue":"9-10","key":"10.2515\/therapie\/2011051_bb0025","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1007\/s002280000235","article-title":"Effects of grapefruit juice on the stereoselective disposition of nicardipine in humans: evidence for dominant presystemic elimination at the gut site","volume":"56","author":"Uno","year":"2000","journal-title":"Eur J Clin Pharmacol"},{"issue":"4","key":"10.2515\/therapie\/2011051_bb0030","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1023\/A:1011089924099","article-title":"Inhibition of P-glycoprotein transport function by grapefruit juice psoralen","volume":"18","author":"Wang","year":"2001","journal-title":"Pharm Res"},{"issue":"6","key":"10.2515\/therapie\/2011051_bb0035","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1023\/A:1016100715125","article-title":"Effects of grapefruit juice and orange juice on the intestinal efflux of P-glycoprotein substrates","volume":"19","author":"Tian","year":"2002","journal-title":"Pharm Res"},{"issue":"4","key":"10.2515\/therapie\/2011051_bb0040","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0928-0987(00)00191-3","article-title":"Grapefruit juice enhances intestinal absorption of the P-glycoprotein substrate talinolol","volume":"12","author":"Spahn-Langguth","year":"2001","journal-title":"Eur J Pharm Sci"},{"issue":"2","key":"10.2515\/therapie\/2011051_bb0045","doi-asserted-by":"crossref","first-page":"157","DOI":"10.2174\/157488406776872550","article-title":"Effect of grapefruit juice in relation to human pharmacokinetic study","volume":"1","author":"Uno","year":"2006","journal-title":"Curr Clin Pharmacol"},{"issue":"4","key":"10.2515\/therapie\/2011051_bb0050","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/sj.clpt.6100104","article-title":"Naringin is a major and selective clinical inhibitor of organic anion-transporting polypeptide 1A2 (OATP1A2) in grapefruit juice","volume":"81","author":"Bailey","year":"2007","journal-title":"Clin Pharmacol Ther"},{"issue":"6","key":"10.2515\/therapie\/2011051_bb0055","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/clpt.1993.195","article-title":"Effect of grapefruit juice and naringin on nisoldipine pharmacokinetics","volume":"54","author":"Bailey","year":"1993","journal-title":"Clin Pharmacol Ther"},{"issue":"3","key":"10.2515\/therapie\/2011051_bb0060","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1016\/S0022-3565(25)11138-5","article-title":"Inhibition of dihydropyridine metabolism in rat and human liver microsomes by flavonoids found in grapefruit juice","volume":"261","author":"Miniscalco","year":"1992","journal-title":"J Pharmacol Exp Ther"},{"issue":"13","key":"10.2515\/therapie\/2011051_bb0065","doi-asserted-by":"crossref","first-page":"5158","DOI":"10.1021\/jf058004g","article-title":"Distribution of furanocoumarins in grapefruit juice fractions","volume":"53","author":"Manthey","year":"2005","journal-title":"J Agric Food Chem"},{"issue":"4","key":"10.2515\/therapie\/2011051_bb0070","doi-asserted-by":"crossref","first-page":"326","DOI":"10.3358\/shokueishi.49.326","article-title":"Contents of furanocoumarins in grapefruit juice and health foods","volume":"49","author":"Sakamaki","year":"2008","journal-title":"Shokuhin Eiseigaku Zasshi"},{"issue":"5","key":"10.2515\/therapie\/2011051_bb0075","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1067\/mcp.2000.110774","article-title":"Grapefruit-felodipine interaction: effect of unprocessed fruit and probable active ingredients","volume":"68","author":"Bailey","year":"2000","journal-title":"Clin Pharmacol Ther"},{"key":"10.2515\/therapie\/2011051_bb0080","first-page":"83","article-title":"La production de jus d\u2019agrumes et l\u2019application des technologies au march\u00e9 des agrumes frais","author":"Johnson","year":"2001","journal-title":"Symposium sur les agrumes Chine\/FAO"},{"issue":"4","key":"10.2515\/therapie\/2011051_bb0085","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1055\/s-0028-1112210","article-title":"In vitro interactions with repeated grapefruit juice administration: to peel or not to peel?","volume":"75","author":"Brill","year":"2009","journal-title":"Planta Med"},{"issue":"2","key":"10.2515\/therapie\/2011051_bb0090","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0378-4347(00)00104-3","article-title":"Amounts and variation in grapefruit juice of the main components causing grapefruit-drug interaction","volume":"741","author":"Fukuda","year":"2000","journal-title":"J Chromatogr B Biomed Sci Appl"},{"issue":"1","key":"10.2515\/therapie\/2011051_bb0095","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1021\/jf0516944","article-title":"Variation of flavonoids and furanocoumarins in grapefruit juices: a potential source of variability in grapefruit juice-drug interaction studies","volume":"54","author":"De Castro","year":"2006","journal-title":"J Agric Food Chem"},{"issue":"2","key":"10.2515\/therapie\/2011051_bb0100","first-page":"135","article-title":"Grapefruit juice-felodipine interaction: reproducibility and characterization with the extended release drug formulation","volume":"40","author":"Bailey","year":"1995","journal-title":"Br J Clin Pharmacol"},{"issue":"3","key":"10.2515\/therapie\/2011051_bb0105","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1016\/S0022-3565(24)37149-6","article-title":"Characterization of interintestinal and intraintestinal variations in human CYP3A-dependent metabolism","volume":"283","author":"Paine","year":"1997","journal-title":"J Pharmacol Exp Ther"},{"issue":"1","key":"10.2515\/therapie\/2011051_bb0110","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s002280050424","article-title":"The interaction effect of grapefruit juice is maximal after the first glass","volume":"54","author":"Lundahl","year":"1998","journal-title":"Eur J Clin Pharmacol"},{"issue":"2","key":"10.2515\/therapie\/2011051_bb0115","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1046\/j.1365-2125.1998.00764.x","article-title":"Grapefruit juice-drug interactions","volume":"46","author":"Bailey","year":"1998","journal-title":"Br J Clin Pharmacol"},{"issue":"4","key":"10.2515\/therapie\/2011051_bb0120","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1067\/mcp.2000.110216","article-title":"Duration of effect of grapefruit juice on the pharmacokinetics of the CYP3A4 substrate simvastatin","volume":"68","author":"Lilja","year":"2000","journal-title":"Clin Pharmacol Ther"},{"issue":"2","key":"10.2515\/therapie\/2011051_bb0125","doi-asserted-by":"crossref","first-page":"103","DOI":"10.2165\/00003088-199733020-00003","article-title":"Drug interactions with grapefruit juice","volume":"33","author":"Ameer","year":"1997","journal-title":"Clin Pharmacokinet"},{"issue":"9","key":"10.2515\/therapie\/2011051_bb0130","doi-asserted-by":"crossref","first-page":"933","DOI":"10.4065\/75.9.933","article-title":"Drug-grapefruit juice interactions","volume":"75","author":"Kane","year":"2000","journal-title":"Mayo Clin Proc"},{"issue":"5","key":"10.2515\/therapie\/2011051_bb0135","first-page":"432","article-title":"Grapefruit juice and drugs: a hazardous combination?","volume":"57","author":"Lohezic-Le Devehat","year":"2002","journal-title":"Therapie"},{"issue":"3","key":"10.2515\/therapie\/2011051_bb0140","first-page":"279","article-title":"Grapefruit juice: potential drug interactions","volume":"167","author":"Maskalyk","year":"2002","journal-title":"CMAJ"},{"issue":"1","key":"10.2515\/therapie\/2011051_bb0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/sj.ejcn.1601736","article-title":"Food-drug interaction: grapefruit juice augments drug bioavailability. Mechanism, extent and relevance","volume":"58","author":"Dahan","year":"2004","journal-title":"Eur J Clin Nutr"},{"issue":"3","key":"10.2515\/therapie\/2011051_bb0150","first-page":"97","article-title":"Grapefruit juice: potential drug interaction","volume":"156","author":"Palumbo","year":"2005","journal-title":"Clin Ter"},{"issue":"11","key":"10.2515\/therapie\/2011051_bb0155","first-page":"12","article-title":"Grapefruit juice and drug interactions. Exploring mechanisms of this interaction and potential toxicity for certain drugs","volume":"61","author":"Bressler","year":"2006","journal-title":"Geriatrics"},{"issue":"1","key":"10.2515\/therapie\/2011051_bb0160","first-page":"39","article-title":"Grapefruit-drug interactions","volume":"18","author":"Straughan","year":"2007","journal-title":"Cardiovasc J S Afr"},{"issue":"4","key":"10.2515\/therapie\/2011051_bb0165","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S0009-9236(97)90189-2","article-title":"Drug interactions with grapefruit: whose responsibility is it to warn the public?","volume":"61","author":"Spence","year":"1997","journal-title":"Clin Pharmacol Ther"},{"issue":"3","key":"10.2515\/therapie\/2011051_bb0170","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/S1053-4296(03)00031-6","article-title":"CTCAE v3.0: development of a comprehensive grading system for the adverse effects of cancer treatment","volume":"13","author":"Trotti","year":"2003","journal-title":"Semin Radiat Oncol"},{"year":"2010","series-title":"Base de donn\u00e9es \u201cLes interactions m\u00e9dicamenteuses\u201d","author":"Garcia","key":"10.2515\/therapie\/2011051_bb0175"},{"issue":"5","key":"10.2515\/therapie\/2011051_bb0180","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0021-9681(87)90171-8","article-title":"A new method of classifying prognostic comorbidity in longitudinal studies: development and validation","volume":"40","author":"Charlson","year":"1987","journal-title":"J Chronic Dis"},{"issue":"6","key":"10.2515\/therapie\/2011051_bb0185","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1007\/s10552-009-9310-6","article-title":"Prospective study of the association between grapefruit intake and risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)","volume":"20","author":"Spencer","year":"2009","journal-title":"Cancer Causes Control"},{"issue":"6B","key":"10.2515\/therapie\/2011051_bb0190","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1079\/PHN2002394","article-title":"European Prospective Investigation into Cancer and Nutrition (EPIC): study populations and data collection","volume":"5","author":"Riboli","year":"2002","journal-title":"Public Health Nutr"},{"year":"2009","series-title":"Union Nationale Interprofessionnelle des Jus de Fruits (UNIJUS)","key":"10.2515\/therapie\/2011051_bb0195"},{"key":"10.2515\/therapie\/2011051_bb0200","first-page":"46","article-title":"The US grapefruit market","volume":"289","author":"Thornsbury","year":"2000","journal-title":"Fruit and Tree Nuts Situation and Outlook Yearbook"},{"year":"2008","series-title":"La consommation alimentaire des hommes et femmes vivant seuls","author":"De Saint Pol","key":"10.2515\/therapie\/2011051_bb0205"},{"key":"10.2515\/therapie\/2011051_bb0210","series-title":"Cinquante ans de consommation en France","first-page":"49","article-title":"La consommation alimentaire: des in\u00e9galit\u00e9s persistantes mais qui se r\u00e9duisent","author":"Caillavet","year":"2009"},{"issue":"6","key":"10.2515\/therapie\/2011051_bb0215","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1248\/bpb.29.1286","article-title":"UV-irradiated grapefruit juice loses pharmacokinetic interaction with nifedipine in rats","volume":"29","author":"Uesawa","year":"2006","journal-title":"Biol Pharm Bull"},{"issue":"11","key":"10.2515\/therapie\/2011051_bb0220","doi-asserted-by":"crossref","first-page":"2274","DOI":"10.1248\/bpb.29.2274","article-title":"The use of heat treatment to eliminate drug interactions due to grapefruit juice","volume":"29","author":"Uesawa","year":"2006","journal-title":"Biol Pharm Bull"}],"container-title":["Therapies"],"original-title":[],"language":"fr","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040595716307867?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040595716307867?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T08:50:13Z","timestamp":1741855813000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040595716307867"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9]]},"references-count":44,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["S0040595716307867"],"URL":"https:\/\/doi.org\/10.2515\/therapie\/2011051","relation":{},"ISSN":["0040-5957"],"issn-type":[{"type":"print","value":"0040-5957"}],"subject":[],"published":{"date-parts":[[2011,9]]}}}