{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T20:28:37Z","timestamp":1790540917840,"version":"4.1.0"},"reference-count":28,"publisher":"Journal of Orthopaedic & Sports Physical Therapy (JOSPT)","issue":"12","content-domain":{"domain":["www.jospt.org"],"crossmark-restriction":true},"short-container-title":["Journal of Orthopaedic &amp; Sports Physical Therapy"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:sec><jats:title>Study Design<\/jats:title><jats:p> Single-blind, block-randomization crossover design. <\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p> To compare the knee extensor muscle torque production elicited with 2500-Hz burst-modulated alternating current (BMAC) and with a monophasic pulsed current (MPC) at the maximum tolerated stimulation intensity. <\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p> Neuromuscular electrical stimulation (NMES) is often used for strengthening the quadriceps following knee surgery. Strength gains are dependent on muscle torque production, which is primarily limited by discomfort. Burst-modulated alternating current stimulation is a clinically popular waveform for NMES. Prior research has established that MPC with a relatively long pulse duration is effective for high muscle torque production. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> Participants in this study were 20 adults with no history of knee injury. A crossover design was used to randomize the order in which each participant's dominant or nondominant lower extremity received NMES and the waveform (MPC or BMAC) this limb received. Stimulation intensity was incrementally increased until participants reached their maximum tolerance. The torque produced was converted to a percentage of each participant's maximum volitional isometric contraction of the respective limb. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> A general linear model for a 2-treatment, 2-period crossover design was utilized to analyze the results. The mean \u00b1 SD electrically induced percent maximum volitional isometric contraction at maximal participant tolerance was 49.5% \u00b1 19.6% for MPC and 29.8% \u00b1 12.4% for BMAC. This difference was statistically significant (P = .002) after ccounting for treatment order and limb, which had no effect on torque production. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> Neuromuscular stimulation using MPC may be more efficacious than using BMAC to achieve a high torque output in patients with quadriceps weakness. J Orthop Sports Phys Ther 2015;45(12):1035\u20131041. 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