{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T19:31:44Z","timestamp":1778182304014,"version":"3.51.4"},"reference-count":114,"publisher":"Journal of Orthopaedic & Sports Physical Therapy (JOSPT)","issue":"11","content-domain":{"domain":["www.jospt.org"],"crossmark-restriction":true},"short-container-title":["Journal of Orthopaedic &amp; Sports Physical Therapy"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:sec><jats:title>Synopsis<\/jats:title><jats:p> Mild traumatic brain injury, or concussion, is a common sports injury. Concussion involves physical injury to brain tissue and vascular and axonal damage that manifests as transient and often nonspecific clinical symptoms. Concussion diagnosis is challenging, and the relationship between brain injury and clinical symptoms is unclear. The purpose of this commentary was to translate cutting-edge neuroscience to rehabilitation practice. We (1) highlight potential biomarkers that may improve our understanding of concussion and its recovery, (2) explain why researchers must address the paucity of concussion research in female athletes, and (3) present female-specific factors that should be accounted for in future studies. Integrating objective, quantitative measures of concussion pathophysiology with concussion history, genetics, and genomics will help caregivers identify concussed athletes, tailor recovery protocols, and protect athletes from potential long-term effects of cumulative head impact. J Orthop Sports Phys Ther 2019;49(11):811\u2013818. Epub 1 Jun 2019. doi:10.2519\/jospt.2019.8884 <\/jats:p><\/jats:sec>","DOI":"10.2519\/jospt.2019.8884","type":"journal-article","created":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T07:30:50Z","timestamp":1559374250000},"page":"811-818","update-policy":"https:\/\/doi.org\/10.2519\/jospt.crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Cutting to the Pathophysiology Chase: Translating Cutting-Edge Neuroscience to Rehabilitation Practice in Sports-Related Concussion Management"],"prefix":"10.2519","volume":"49","author":[{"given":"Yufen","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy A.","family":"Herrold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia T.","family":"Gallagher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James L.","family":"Reilly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Todd","family":"Parrish","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans C.","family":"Breiter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1394","reference":[{"key":"bib1","doi-asserted-by":"publisher","DOI":"10.1089\/brain.2014.0279"},{"key":"bib2","doi-asserted-by":"publisher","DOI":"10.1080\/87565641.2014.990455"},{"key":"bib3","doi-asserted-by":"publisher","DOI":"10.1037\/pha0000057"},{"key":"bib4","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2011.00002"},{"key":"bib5","doi-asserted-by":"crossref","unstructured":"American Congress of Rehabilitation Medicine.  Definition of mild traumatic brain injury.  J Head Trauma Rehabil.  1993; 8: 86\u2013 87.","DOI":"10.1097\/00001199-199309000-00010"},{"key":"bib6","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.07.011"},{"key":"bib7","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2006.07.275"},{"key":"bib8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0162168"},{"key":"bib9","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2016.4634"},{"key":"bib10","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00045-5"},{"key":"bib11","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2009.1068"},{"key":"bib12","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2012.08.015"},{"key":"bib13","doi-asserted-by":"publisher","DOI":"10.1038\/srep28148"},{"key":"bib14","doi-asserted-by":"publisher","DOI":"10.1067\/mcp.2001.113989"},{"key":"bib15","doi-asserted-by":"publisher","DOI":"10.1007\/s40279-016-0582-1"},{"key":"bib16","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1440.011"},{"key":"bib17","doi-asserted-by":"publisher","DOI":"10.1080\/16501960410023877"},{"key":"bib18","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2017.00390"},{"key":"bib19","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.10091842"},{"key":"bib20","doi-asserted-by":"publisher","DOI":"10.4085\/1062-6050-51.3.05"},{"key":"bib21","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000279972.95060.CB"},{"key":"bib22","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2007.11.005"},{"key":"bib23","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-014-9312-1"},{"key":"bib24","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0601417103"},{"key":"bib25","first-page":"1","volume":"62","author":"Daniels K","year":"2013","journal-title":"Natl Health Stat Report"},{"key":"bib26","doi-asserted-by":"publisher","DOI":"10.3171\/2009.10.FOCUS09215"},{"key":"bib27","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-012-2572-5"},{"key":"bib28","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910230106"},{"key":"bib29","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0703"},{"key":"bib30","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2017.11.001"},{"key":"bib31","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2016.4480"},{"key":"bib32","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.392"},{"key":"bib33","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2007.02.038"},{"key":"bib34","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0195318"},{"key":"bib35","first-page":"19","volume":"4","author":"Fox MD","year":"2010","journal-title":"Front Syst Neurosci."},{"key":"bib36","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2017.5453"},{"key":"bib37","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2012.07.005"},{"key":"bib38","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00966.2005"},{"key":"bib39","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2239-05.2005"},{"key":"bib40","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2018.07.020"},{"key":"bib41","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.19.2549"},{"key":"bib42","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20198"},{"key":"bib43","doi-asserted-by":"publisher","DOI":"10.1038\/nrg1379"},{"key":"bib44","doi-asserted-by":"publisher","DOI":"10.2340\/16501977-0100"},{"key":"bib45","doi-asserted-by":"publisher","DOI":"10.1093\/milmed\/usy306"},{"key":"bib46","doi-asserted-by":"publisher","DOI":"10.1519\/JSC.0b013e31828a1fe2"},{"key":"bib47","doi-asserted-by":"publisher","DOI":"10.1002\/lio2.74"},{"key":"bib48","doi-asserted-by":"publisher","DOI":"10.1097\/01.yco.0000165601.29047.ae"},{"key":"bib49","doi-asserted-by":"publisher","DOI":"10.1207\/S15324826AN1003_02"},{"key":"bib50","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2018.09.011"},{"key":"bib51","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2014.3415"},{"key":"bib52","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.07.081"},{"key":"bib53","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-014-9316-x"},{"key":"bib54","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-006-9251-3"},{"key":"bib55","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.09.067"},{"key":"bib56","doi-asserted-by":"publisher","DOI":"10.1007\/s002210100711"},{"key":"bib57","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A5692"},{"key":"bib58","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-008-0073-0"},{"key":"bib59","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910340613"},{"key":"bib60","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.1076"},{"key":"bib61","doi-asserted-by":"publisher","DOI":"10.2519\/jospt.2016.6944"},{"key":"bib62","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2018.5629"},{"key":"bib63","volume-title":"VA\/DoD Clinical Practice Guideline for the Management of Concussion-Mild Traumatic Brain Injury","author":"Management of Concussion-mild Traumatic Brain Injury Working Group","year":"2016"},{"key":"bib64","doi-asserted-by":"publisher","DOI":"10.1177\/0363546511435626"},{"key":"bib65","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiotec.2011.01.023"},{"key":"bib66","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-2083"},{"key":"bib67","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.21151"},{"key":"bib68","doi-asserted-by":"publisher","DOI":"10.1097\/00042752-200401000-00003"},{"key":"bib69","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1136\/bjsports-2017-097699","volume":"51","author":"McCrory P","year":"2017","journal-title":"Br J Sports Med."},{"key":"bib70","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-016-9520-y"},{"key":"bib71","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2014.4778"},{"key":"bib72","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23072"},{"key":"bib73","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617715001022"},{"key":"bib74","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617718000413"},{"key":"bib75","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2017.5158"},{"key":"bib76","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00023"},{"key":"bib77","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2016.00107"},{"key":"bib78","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2013-093406"},{"key":"bib79","doi-asserted-by":"publisher","DOI":"10.4085\/1062-6050.52.2.05"},{"key":"bib80","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.24.9868"},{"key":"bib81","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2016.4833"},{"key":"bib82","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2018.6072"},{"key":"bib83","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsams.2014.07.010"},{"key":"bib84","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.12.016"},{"key":"bib85","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2013.11.007"},{"key":"bib86","doi-asserted-by":"publisher","DOI":"10.1007\/s00062-015-0432-9"},{"key":"bib87","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2014.3455"},{"key":"bib88","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2009.12.011"},{"key":"bib89","doi-asserted-by":"publisher","DOI":"10.1093\/epirev\/mxt007"},{"key":"bib90","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2007.06.011"},{"key":"bib91","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwh304"},{"key":"bib92","doi-asserted-by":"publisher","DOI":"10.5435\/JAAOS-D-16-00684"},{"key":"bib93","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9781585624201"},{"key":"bib94","doi-asserted-by":"publisher","DOI":"10.1249\/JSR.0000000000000268"},{"key":"bib95","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2017.03.006"},{"key":"bib96","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2011.01.019"},{"key":"bib97","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2017.5237"},{"key":"bib98","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-016-9509-6"},{"key":"bib99","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2016-097419"},{"key":"bib100","doi-asserted-by":"publisher","DOI":"10.1097\/JSM.0b013e3181fc0a81"},{"key":"bib101","first-page":"271","volume":"6","author":"Ting WK","year":"2015","journal-title":"Front Neurol."},{"key":"bib102","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.13583"},{"key":"bib103","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2017.5622"},{"key":"bib104","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25358"},{"key":"bib105","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2015.4072"},{"key":"bib106","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-018-9946-5"},{"key":"bib107","doi-asserted-by":"publisher","DOI":"10.1080\/87565641.2014.979927"},{"key":"bib108","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00575"},{"key":"bib109","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4392-08.2008"},{"key":"bib110","doi-asserted-by":"publisher","DOI":"10.1097\/PSY.0b013e318244c604"},{"key":"bib111","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-017-9752-5"},{"key":"bib112","doi-asserted-by":"publisher","DOI":"10.1097\/HTR.0000000000000006"},{"key":"bib113","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2013.9"},{"key":"bib114","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2014.3413"}],"container-title":["Journal of Orthopaedic &amp; Sports Physical Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jospt.org\/doi\/pdf\/10.2519\/jospt.2019.8884","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T13:56:36Z","timestamp":1724680596000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jospt.org\/doi\/10.2519\/jospt.2019.8884"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":114,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["10.2519\/jospt.2019.8884"],"URL":"https:\/\/doi.org\/10.2519\/jospt.2019.8884","relation":{},"ISSN":["0190-6011","1938-1344"],"issn-type":[{"value":"0190-6011","type":"print"},{"value":"1938-1344","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11]]},"assertion":[{"value":"2019-10-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}