{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T06:39:31Z","timestamp":1792305571401,"version":"4.4.0"},"reference-count":47,"publisher":"Journal of Orthopaedic & Sports Physical Therapy (JOSPT)","issue":"6","content-domain":{"domain":["www.jospt.org"],"crossmark-restriction":true},"short-container-title":["Journal of Orthopaedic &amp; Sports Physical Therapy"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:p> OBJECTIVE: To investigate the comparative effectiveness of nonsurgical interventions for adults with acute and subacute sciatica. <\/jats:p><jats:p> DESIGN: Intervention systematic review with network meta-analysis <\/jats:p><jats:p> LITERATURE SEARCH: Embase, MEDLINE, Cochrane Library, and CINAHL were searched up to June 7, 2024. <\/jats:p><jats:p> STUDY SELECTION CRITERIA: Randomized controlled trials of nonsurgical interventions in adults (aged 18 years or older) with acute or subacute sciatica (less than 3 months) were included. <\/jats:p><jats:p> DATA SYNTHESIS: The primary outcomes were leg pain intensity and physical function at different follow-up time points. Secondary outcomes were adverse events, mental health, and low back pain intensity. Two reviewers independently conducted screening, data extraction, and risk-of-bias assessment. Random-effects network meta-analysis was conducted, and confidence was evaluated by the Confidence in Network Meta-Analysis (CINeMA) method. <\/jats:p><jats:p> RESULTS: Forty randomized controlled trials (5381 participants) were included. At short-term follow-up, compared to sham treatment\/placebo, the most efficacious interventions for leg pain intensity were NSAIDs + physical therapy modalities, antibiotics, and antidepressants. Music therapy was effective for improving physical function at short-term follow-up. At long-term follow-up, steroids had a significant effect in reducing leg pain and improving physical function. No intervention showed a significant increase in adverse events compared with sham-treatment\/placebo. All the evidence was based on very low confidence, primarily due to within-study bias and imprecision in effect estimates. <\/jats:p><jats:p> CONCLUSIONS: Very low\u2013confidence evidence supported some nonsurgical interventions for improving leg pain intensity and physical function in people with acute and subacute sciatica. J Orthop Sports Phys Ther 2025;55(6):407-418. 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