{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:16:29Z","timestamp":1787170589297,"version":"build-2736575974"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,7,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Purpose<\/jats:title>\n                    <jats:p>The clinical symptoms of Huntington disease (HD) include progressive movement disorders, cognitive deficits, and behavioral changes, all of which affect an individual's ability to participate in activities of daily living. To date, very few quantitative or qualitative studies have been conducted to guide physical therapists working with people with HD. The objective of this study was to characterize current physical therapist practice for people with HD, thus informing the development of standardized clinical care and future research studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects and Methods<\/jats:title>\n                    <jats:p>Consultation with physical therapists working with people with HD was undertaken in the form of mailed questionnaires (n=49) and semistructured interviews (n=8). The development of the interview schedule was aided by consideration of the data obtained from the questionnaires. Themes identified from the interviews were considered in light of published literature and questionnaire responses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The main issues that emerged from the interviews were classified into 3 subthemes: (1) there is insufficient use of routine physical therapy\u2013related outcome measures at different stages of HD, (2) there is underutilization of physical therapy services in managing HD (particularly in the early stages), and (3) the management of falls and mobility deficit progression is a key treatment aim for people with HD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion and Conclusion<\/jats:title>\n                    <jats:p>A conceptual framework for physical therapy intervention in HD was developed on the basis of the themes that emerged from the data in this study. Such a framework has utility for complex, progressive conditions such as HD and may facilitate clinical decision making and standardization of practice and affect the development of future physical therapy trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2522\/ptj.20070346","type":"journal-article","created":{"date-parts":[[2008,5,8]],"date-time":"2008-05-08T20:53:41Z","timestamp":1210280021000},"page":"820-831","source":"Crossref","is-referenced-by-count":45,"title":["Physical Therapy Intervention for People With Huntington Disease"],"prefix":"10.1093","volume":"88","author":[{"given":"Monica E","family":"Busse","sequence":"first","affiliation":[{"name":"ME Busse, PhD, is Lecturer, Department of Physiotherapy, School of Health Care Studies, Cardiff University, Ty Dewi Sant, Heath Park, Cardiff CF14 4XN, Wales, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanan","family":"Khalil","sequence":"additional","affiliation":[{"name":"H Khalil, MSc, is Lecturer, Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid, Jordan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori","family":"Quinn","sequence":"additional","affiliation":[{"name":"L Quinn, PT, EdD, is Honorary Research Fellow, Department of Physiotherapy, School of Health Care Studies, Cardiff University, and Senior Lecturer, Program in Physical Therapy, School of Public Health, New York Medical College, Valhalla, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne E","family":"Rosser","sequence":"additional","affiliation":[{"name":"AE Rosser, PhD, is Professor of Clinical Neuroscience, Departments of Neurology and Medical Genetics, School of Medicine, Cardiff University, and Brain Repair Group, School of Biosciences, Cardiff University."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"key":"2019123109374626900_R1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1097\/00004850-200403000-00001","article-title":"Huntington's disease: present treatments and future therapeutic modalities","volume":"19","author":"Bonelli","year":"2004","journal-title":"Int Clin Psychopharmacol"},{"issue":"1","key":"2019123109374626900_R2","first-page":"22","article-title":"A physical therapy program for Huntington's disease patients","volume":"7","author":"Peacock","year":"1987","journal-title":"Clinical Management in Physical Therapy"},{"key":"2019123109374626900_R3","first-page":"19","article-title":"Huntington's disease: falling through the net","volume":"25","author":"Shakspeare","year":"1993","journal-title":"Health Trends"},{"key":"2019123109374626900_R4","doi-asserted-by":"crossref","first-page":"83","DOI":"10.12968\/bjon.1997.6.2.83","article-title":"Using research to develop care for patients with Huntington's disease","volume":"6","author":"Skirton","year":"1997","journal-title":"Br J Nurs"},{"key":"2019123109374626900_R5","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.brainresbull.2006.10.021","article-title":"Can directed activity improve mobility in Huntington's disease","volume":"72","author":"Busse","year":"2007","journal-title":"Brain Res Bull"},{"issue":"5","key":"2019123109374626900_R6","first-page":"62","article-title":"Huntington's disease at mid-stage","volume":"12","author":"Imbriglio","year":"1992","journal-title":"Clinical Management in Physical Therapy"},{"key":"2019123109374626900_R7","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1097\/01253086-200226030-00006","article-title":"Physical therapy for people with Huntington disease: current perspectives and case report","volume":"26","author":"Quinn","year":"2002","journal-title":"Neurol Rep"},{"key":"2019123109374626900_R8","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1037\/0735-7044.114.2.431","article-title":"Behavioral recovery after transplantation into a rat model of Huntington's disease: dependence on anatomical connectivity and extensive postoperative training","volume":"114","author":"Brasted","year":"2000","journal-title":"Behav Neurosci"},{"key":"2019123109374626900_R9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1515\/REVNEURO.2005.16.1.1","article-title":"Optimising plasticity: environmental and training associated factors in transplant-mediated brain repair","volume":"16","author":"D\u00f6br\u00f6ssy","year":"2005","journal-title":"Rev Neurosci"},{"key":"2019123109374626900_R10","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1111\/j.1460-9568.2006.04715.x","article-title":"Neurogenesis in the R6\/1 transgenic mouse model of Huntington's disease: effects of environmental enrichment","volume":"23","author":"Lazic","year":"2006","journal-title":"Eur J Neurosci"},{"key":"2019123109374626900_R11","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.neuroscience.2006.04.013","article-title":"Differential effects of voluntary physical exercise on behavioral and brain-derived neurotrophic factor expression deficits in Huntington's disease transgenic mice","author":"Pang","year":"2006","journal-title":"Neuroscience"},{"key":"2019123109374626900_R12","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1177\/0269215507075495","article-title":"Effects of an intensive rehabilitation programme on patients with Huntington's disease: a pilot study","volume":"21","author":"Zinzi","year":"2007","journal-title":"Clin Rehabil"},{"key":"2019123109374626900_R13","first-page":"215","article-title":"Approaches to qualitative data collection in social science","author":"Carter","year":"2005","journal-title":"Handbook of Health Research Methods: Investigation, Measurement and Analysis"},{"key":"2019123109374626900_R14","volume-title":"Qualitative Evaluation and Research Methods","author":"Patton","year":"1990"},{"key":"2019123109374626900_R15","volume-title":"Nursing Research Process: An Australian Perspective","author":"Roberts","year":"1998"},{"key":"2019123109374626900_R16","volume-title":"Nursing Research: Principles and Methods","author":"Polite","year":"1999"},{"key":"2019123109374626900_R17","first-page":"515","article-title":"Key issues in the analysis of qualitative data in health services research","author":"Donovan","year":"2005","journal-title":"Handbook of Health Research Methods: Investigation, Measurement and Analysis"},{"key":"2019123109374626900_R18","volume-title":"Therapy Research: Processes and Practicalities","author":"Seal","year":"2007"},{"key":"2019123109374626900_R19","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1097\/01253086-200226030-00003","article-title":"A framework for rehabilitation of neurodegenerative diseases: planning care and maximizing quality of life","volume":"26","author":"Dal Bello-Haas","year":"2002","journal-title":"Neurol Rep"},{"key":"2019123109374626900_R20","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1002\/mds.870130609","article-title":"Unified Huntington's disease rating scale: a follow up","volume":"13","author":"Siesling","year":"1998","journal-title":"Mov Disord"},{"key":"2019123109374626900_R21","first-page":"350","article-title":"Geriatric work-up in the Nordic countries: the Nordic approach to comprehensive geriatric assessment","volume":"43","author":"Sletvold","year":"1996","journal-title":"Dan Med Bull"},{"key":"2019123109374626900_R22","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1093\/ptj\/86.5.646","article-title":"Timed \u201cUp & Go\u201d Test: reliability in older people dependent in activities of daily living\u2014focus on cognitive state","volume":"86","author":"Nordin","year":"2006","journal-title":"Phys Ther"},{"key":"2019123109374626900_R23","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1111\/j.1532-5415.1996.tb06417.x","article-title":"Gait disorders in older adults","volume":"44","author":"Alexander","year":"1996","journal-title":"J Am Geriatr Soc"},{"key":"2019123109374626900_R24","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s00391-004-0176-7","article-title":"Systematic review of quantitative clinical gait analysis in patients with dementia","volume":"37","author":"van Iersel","year":"2004","journal-title":"J Gerontol Geriatr"},{"key":"2019123109374626900_R25","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1002\/mds.20482","article-title":"Reliability of spatiotemporal gait outcome measures in Huntington's disease","volume":"20","author":"Rao","year":"2005","journal-title":"Mov Disord"},{"key":"2019123109374626900_R26","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/ana.10094","article-title":"Environmental enrichment slows disease progression in R6\/2 Huntington's disease mice","volume":"51","author":"Hockly","year":"2002","journal-title":"Ann Neurol"},{"key":"2019123109374626900_R27","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/35008142","article-title":"Delaying the onset of Huntington's in mice","volume":"404","author":"van Dellen","year":"2000","journal-title":"Nature"},{"key":"2019123109374626900_R28","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1212\/WNL.35.10.1450","article-title":"The gait abnormality of Huntington's disease","volume":"35","author":"Koller","year":"1985","journal-title":"Neurology"},{"key":"2019123109374626900_R29","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1177\/0888439002250448","article-title":"Effectiveness of physiotherapy, occupational therapy, and speech pathology for people with Huntington's disease: a systematic review","volume":"17","author":"Bilney","year":"2003","journal-title":"Neurorehabil Neural Repair"},{"issue":"6","key":"2019123109374626900_R30","first-page":"17","article-title":"Huntington's disease, occupational therapy, and lemonade","volume":"6","author":"Clerico","year":"2001","journal-title":"OT Practice"},{"key":"2019123109374626900_R31","first-page":"375","article-title":"Gait dysfunction in Huntington's disease: parkinsonism and a disorder of timing\u2014implications for movement rehabilitation","volume":"87","author":"Churchyard","year":"2001","journal-title":"Adv Neurol"},{"key":"2019123109374626900_R32","first-page":"94","article-title":"Physiotherapy for people with movement disorders arising from basal ganglia dysfunction","volume":"31","author":"Bilney","year":"2003","journal-title":"New Zealand Journal of Physiotherapy"},{"key":"2019123109374626900_R33","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1212\/01.WNL.0000052992.58107.67","article-title":"Predictors of nursing home placement in Huntington disease","volume":"60","author":"Wheelock","year":"2003","journal-title":"Neurology"},{"key":"2019123109374626900_R34","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD002815","article-title":"A comparison of physiotherapy techniques for patients with Parkinson's disease","author":"Deane","year":"2001","journal-title":"Cochrane Database Syst Rev"},{"key":"2019123109374626900_R35","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD002815","article-title":"Physiotherapy for patients with Parkinson's disease: a comparison of techniques","author":"Deane","year":"2001","journal-title":"Cochrane Database Syst Rev"},{"key":"2019123109374626900_R36","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1136\/bmj.321.7262.694","article-title":"Framework for design and evaluation of complex interventions to improve health","volume":"321","author":"Campbell","year":"2000","journal-title":"BMJ"}],"container-title":["Physical Therapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ptj\/article-pdf\/88\/7\/820\/31667210\/ptj0820.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/ptj\/article-pdf\/88\/7\/820\/31667210\/ptj0820.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,5]],"date-time":"2020-05-05T07:34:48Z","timestamp":1588664088000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ptj\/article\/88\/7\/820\/2742395"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7,1]]},"references-count":36,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2008,7,1]]}},"URL":"https:\/\/doi.org\/10.2522\/ptj.20070346","relation":{},"ISSN":["0031-9023","1538-6724"],"issn-type":[{"value":"0031-9023","type":"print"},{"value":"1538-6724","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,7,1]]}}}