{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T11:24:31Z","timestamp":1775129071281,"version":"3.50.1"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,7,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Earlier studies have demonstrated low peak oxygen uptake (V\u0307o2peak) in children with spina bifida. Low peak heart rate and low peak respiratory exchange ratio in these studies raised questions regarding the true maximal character of V\u0307o2peak values obtained with treadmill testing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to determine whether the V\u0307o2peak measured during an incremental treadmill test is a true reflection of the maximum oxygen uptake (V\u0307o2max) in children who have spina bifida and are ambulatory.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A cross-sectional design was used for this study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty children who had spina bifida and were ambulatory participated. The V\u0307o2peak was measured during a graded treadmill exercise test. The validity of V\u0307o2peak measurements was evaluated by use of previously described guidelines for maximum exercise testing in children who are healthy, as well as differences between V\u0307o2peak and V\u0307o2 during a supramaximal protocol (V\u0307o2supramaximal).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The average values for V\u0307o2peak and normalized V\u0307o2peak were, respectively, 1.23 L\/min (SD=0.6) and 34.1 mL\/kg\/min (SD=8.3). Fifteen children met at least 2 of the 3 previously described criteria; one child failed to meet any criteria. Although there were no significant differences between V\u0307o2peak and V\u0307o2supramaximal, 5 children did show improvement during supramaximal testing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Limitations<\/jats:title><jats:p>These results apply to children who have spina bifida and are at least community ambulatory.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The V\u0307o2peak measured during an incremental treadmill test seems to reflect the true V\u0307o2max in children who have spina bifida and are ambulatory, validating the use of a treadmill test for these children. When confirmation of maximal effort is needed, the addition of supramaximal testing of children with disability is an easy and well-tolerated method.<\/jats:p><\/jats:sec>","DOI":"10.2522\/ptj.20080328","type":"journal-article","created":{"date-parts":[[2009,5,30]],"date-time":"2009-05-30T00:51:17Z","timestamp":1243644677000},"page":"679-687","source":"Crossref","is-referenced-by-count":25,"title":["Treadmill Testing of Children Who Have Spina Bifida and Are Ambulatory: Does Peak Oxygen Uptake Reflect Maximum Oxygen Uptake?"],"prefix":"10.1093","volume":"89","author":[{"given":"Janke Frederike","family":"de Groot","sequence":"first","affiliation":[{"name":"J.F. de Groot, PT, MSc, is Researcher, Research Group Lifestyle and Health, University of Applied Sciences, Utrecht, the Netherlands, and Department of Pediatric Physical Therapy and Exercise Physiology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Room kb.02.056.0, PO Box 85090, 3508 AB Utrecht, the Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Takken","sequence":"additional","affiliation":[{"name":"T. Takken, PhD, is Medical Physiologist, Department of Pediatric Physical Therapy and Exercise Physiology, Wilhelmina Children's Hospital, University Medical Center Utrecht."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanna","family":"de Graaff","sequence":"additional","affiliation":[{"name":"S. de Graaff, MSc, was a medical student, Faculty of Medicine, University Medical Center Utrecht, at the time of the study."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rob H.J.M.","family":"Gooskens","sequence":"additional","affiliation":[{"name":"R.H.J.M. Gooskens, is Professor and Child Neurologist, Department of Pediatric Neurology, Wilhelmina Children's Hospital, University Medical Center Utrecht."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul J.M.","family":"Helders","sequence":"additional","affiliation":[{"name":"P.J.M. Helders, PT, PhD, PCS, is Professor, Department of Pediatric Physical Therapy and Exercise Physiology, Wilhelmina Children's Hospital, University Medical Center Utrecht."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luc","family":"Vanhees","sequence":"additional","affiliation":[{"name":"L. 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