{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T15:47:03Z","timestamp":1787845623143,"version":"build-2784847793"},"reference-count":78,"publisher":"Oxford University Press (OUP)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,12,1]]},"abstract":"<jats:p>Patients admitted to the intensive care unit (ICU) can develop a condition referred to as \u201cICU-acquired weakness.\u201d This condition is characterized by profound weakness that is greater than might be expected to result from prolonged bed rest. Intensive care unit\u2013acquired weakness often is accompanied by dysfunction of multiple organ systems. Individuals with ICU-acquired weakness typically have significant activity limitations, often requiring physical assistance for even the most basic activities associated with bed mobility. Many of these individuals have activity limitations months to years after hospitalization. The purpose of this article is to review evidence that guides physical rehabilitation of people with ICU-acquired weakness. Included are diagnostic criteria, medical management, and prognostic indicators, as well as criteria for beginning physical rehabilitation, with an emphasis on patient safety. Data are presented indicating that rehabilitation can be implemented with very few adverse effects. Evidence is provided for appropriate measurement approaches and for physical intervention strategies. Finally, some of the key issues are summarized that should be investigated to determine the best intervention guidelines for individuals with ICU-acquired weakness.<\/jats:p>","DOI":"10.2522\/ptj.20110117","type":"journal-article","created":{"date-parts":[[2012,1,27]],"date-time":"2012-01-27T03:16:45Z","timestamp":1327634205000},"page":"1494-1506","source":"Crossref","is-referenced-by-count":71,"title":["Intensive Care Unit\u2013Acquired Weakness: Implications for Physical Therapist Management"],"prefix":"10.1093","volume":"92","author":[{"given":"Amy","family":"Nordon-Craft","sequence":"first","affiliation":[{"name":"A. Nordon-Craft, PT, DSc, Department of Physical Therapy, School of Health Professions, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, MET 535, Fort Worth, TX 76107 (USA)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Moss","sequence":"additional","affiliation":[{"name":"M. Moss, MD, Department of Pulmonary Sciences\u2013Critical Care Medicine, School of Medicine, University of Colorado Denver."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianna","family":"Quan","sequence":"additional","affiliation":[{"name":"D. Quan, MD, Department of Neurology, School of Medicine, University of Colorado Denver."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Schenkman","sequence":"additional","affiliation":[{"name":"M. 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