{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:15:41Z","timestamp":1787170541533,"version":"build-2736575974"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,11,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Task-specific training may be a suitable intervention to address mobility limitations in people with Huntington disease (HD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of this study was to assess the feasibility and safety of goal-directed, task-specific mobility training for individuals with mid-stage HD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>This study was a randomized, blinded, feasibility trial; participants were randomly assigned to control (usual care) and intervention groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>This multisite study was conducted in 6 sites in the United Kingdom.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients<\/jats:title>\n                    <jats:p>Thirty individuals with mid-stage HD (13 men, 17 women; mean age=57.0 years, SD=10.1) were enrolled and randomly assigned to study groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Intervention<\/jats:title>\n                    <jats:p>Task-specific training was conducted by physical therapists in participants' homes, focusing on walking, sit-to-stand transfers, and standing, twice a week for 8 weeks. Goal attainment scaling was used to individualize the intervention and monitor achievement of personal goals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>Adherence and adverse events were recorded. Adjusted between-group comparisons on standardized outcome measures were conducted at 8 and 16 weeks to determine effect sizes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Loss to follow-up was minimal (n=2); adherence in the intervention group was excellent (96.9%). Ninety-two percent of goals were achieved at the end of the intervention; 46% of the participants achieved much better than expected outcomes. Effect sizes on all measures were small.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Limitations<\/jats:title>\n                    <jats:p>Measurements of walking endurance were lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The safety of and excellent adherence to a home-based, task-specific training program, in which most participants exceeded goal expectations, are encouraging given the range of motivational, behavioral, and mobility issues in people with HD. The design of the intervention in terms of frequency (dose), intensity (aerobic versus anaerobic), and specificity (focused training on individual tasks) may not have been sufficient to elicit any systematic effects. Thus, a larger-scale trial of this specific intervention does not seem warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2522\/ptj.20140123","type":"journal-article","created":{"date-parts":[[2014,7,11]],"date-time":"2014-07-11T00:59:12Z","timestamp":1405040352000},"page":"1555-1568","source":"Crossref","is-referenced-by-count":31,"title":["Task-Specific Training in Huntington Disease: A Randomized Controlled Feasibility Trial"],"prefix":"10.1093","volume":"94","author":[{"given":"Lori","family":"Quinn","sequence":"first","affiliation":[{"name":"L. Quinn, PT, PhD, School of Healthcare Sciences, Cardiff University, Cardiff, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katy","family":"Debono","sequence":"additional","affiliation":[{"name":"K. Debono, BSc AnatomicalScience(Hons), BSc Physiotherapy, MCSP, School of Healthcare Sciences, Cardiff University."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Dawes","sequence":"additional","affiliation":[{"name":"H. Dawes, PhD, MMedSci, Movement Science Group, Oxford Brookes University, Oxford, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Elizabeth","family":"Rosser","sequence":"additional","affiliation":[{"name":"A.E. Rosser, PhD, MB, BChir, BA(Hons), Schools of Medicine and Biosciences, Cardiff University."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea H.","family":"Nemeth","sequence":"additional","affiliation":[{"name":"A.H. Nemeth, MB, BS, DPhil, CCST, Department of Clinical Genetics, Churchill Hospital, Oxford."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugh","family":"Rickards","sequence":"additional","affiliation":[{"name":"H. Rickards, MB, ChB, MMedSci, MRCPsych, MD, FRCPsych, The Barberry Centre, Birmingham, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah J.","family":"Tabrizi","sequence":"additional","affiliation":[{"name":"S.J. Tabrizi, FRCP, PhD, FMedSci, BSc(Hons), Department of Neurodegenerative Diseases, UCL Institute of Neurology, University College London, Queen Square, London, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Quarrell","sequence":"additional","affiliation":[{"name":"O. Quarrell, MD, FRCP, BSc, Sheffield Children's Hospital, Sheffield, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Trender-Gerhard","sequence":"additional","affiliation":[{"name":"I. 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Busse, PhD, MSc(Med), BSc(Med)Hons, MCSP, BSc(Physiotherapy), School of Healthcare Sciences, Cardiff University, Ty Dewi Sant, Heath Park, Cardiff, CF14 4XN United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the members of the TRAIN-HD project group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"key":"2019123008175740500_B1","first-page":"375","article-title":"Gait dysfunction in Huntington's disease: parkinsonism and a disorder of timing\u2014implications for movement rehabilitation","volume":"87","author":"Churchyard","year":"2001","journal-title":"Adv Neurol"},{"key":"2019123008175740500_B2","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1002\/mds.21896","article-title":"Role of attentional resources on gait performance in Huntington's disease","volume":"23","author":"Delval","year":"2008","journal-title":"Mov Disord"},{"key":"2019123008175740500_B3","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1002\/mds.21987","article-title":"Spectrum of gait impairments in presymptomatic and symptomatic Huntington's disease","volume":"23","author":"Rao","year":"2008","journal-title":"Mov Disord"},{"key":"2019123008175740500_B4","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.gaitpost.2010.12.025","article-title":"Postural deficits in Huntington's disease when performing motor skills involved in daily living","volume":"33","author":"Panzera","year":"2011","journal-title":"Gait Posture"},{"key":"2019123008175740500_B5","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jns.2010.08.002","article-title":"Deficits in stepping response time are associated with impairments in balance and mobility in people with Huntington disease","volume":"298","author":"Goldberg","year":"2010","journal-title":"J Neurol Sci"},{"key":"2019123008175740500_B6","doi-asserted-by":"crossref","first-page":"333","DOI":"10.3109\/00016489109131415","article-title":"Postural control in Huntington's disease (HD)","volume":"481","author":"Tian","year":"1991","journal-title":"Acta Otolaryngol Suppl"},{"key":"2019123008175740500_B7","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1136\/jnnp.2008.147793","article-title":"Mobility and falls in people with Huntington's disease","volume":"80","author":"Busse","year":"2009","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2019123008175740500_B8","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/S0014-4886(03)00028-1","article-title":"Motor training effects on recovery of function after striatal lesions and striatal grafts","volume":"184","author":"D\u00f6br\u00f6ssy","year":"2003","journal-title":"Exp Neurol"},{"key":"2019123008175740500_B9","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1111\/j.1460-9568.2006.04715.x","article-title":"Neurogenesis in the R6\/1 transgenic mouse model of Huntington's disease: effects of environmental enrichment","volume":"23","author":"Lazic","year":"2006","journal-title":"Eur J Neurosci"},{"key":"2019123008175740500_B10","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.neuroscience.2005.01.016","article-title":"Training specificity, graft development and graft-mediated functional recovery in a rodent model of Huntington's disease","volume":"132","author":"D\u00f6br\u00f6ssy","year":"2005","journal-title":"Neuroscience"},{"key":"2019123008175740500_B11","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s002210050877","article-title":"Behavioural recovery following striatal transplantation: effects of postoperative training and P-zone volume","volume":"128","author":"Brasted","year":"1999","journal-title":"Exp Brain Res"},{"key":"2019123008175740500_B12","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/nan.12102","article-title":"Environmental enrichment and brain repair: harnessing the therapeutic effects of cognitive stimulation and physical activity to enhance experience-dependent plasticity","volume":"40","author":"Hannan","year":"2014","journal-title":"Neuropathol Appl Neurobiol"},{"key":"2019123008175740500_B13","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1177\/0269215512473762","article-title":"What effect does a structured home-based exercise programme have on people with Huntington's disease? 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