{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T12:53:11Z","timestamp":1770295991535,"version":"3.49.0"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"2","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There is increasing interest in measuring the quality of survivorship for patients admitted to the intensive care unit for acute respiratory failure (ARF). However, there is substantial variability in patient outcomes reported in studies evaluating these patients, with few data on which outcomes are essential to inform clinical practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objectives of this study were to determine clinicians\u2019 perspectives on the outcome domains that should always be reported in studies evaluating people who have had ARF after hospital discharge and to compare findings about US and Australian perspectives.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A modified Delphi method was used for the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A survey with 19 possible domains was developed to iteratively elicit clinicians\u2019 perspectives on core outcome domains via a modified Delphi method. The survey was initially administered online. The survey results were then discussed independently at meetings at scientific conferences in the United States and Australia, and the survey was repeated at the meetings after the discussions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The numbers of participants who responded to both the online and the real-time polling were 44 of 100 (44%) in the United States and 78 of 85 (92%) in Australia. Most respondents were intensive care unit\u2013based clinicians (United States: 33 [75%]; Australia: 76 [97%]). For the 19 domains evaluated, both US and Australian groups ranked physical function and symptoms as the most important domain, with quality of life, cognitive function and symptoms, and survival being the next 3 most important domains. These data yielded a total of 4 domains meeting the criteria for inclusion as core domains at both meetings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Limitations<\/jats:title><jats:p>Several key constituencies, including patients and caregivers, were not represented in this study; their perspectives are also important and ideally should be included in the development of a comprehensive core outcome set.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Clinicians agreed that physical function and symptoms, quality of life, cognitive function, and survival were domains that should always be measured in research evaluating outcomes for people who have had ARF after hospital discharge.<\/jats:p><\/jats:sec>","DOI":"10.2522\/ptj.20160196","type":"journal-article","created":{"date-parts":[[2016,10,7]],"date-time":"2016-10-07T01:39:35Z","timestamp":1475804375000},"page":"168-174","source":"Crossref","is-referenced-by-count":13,"title":["Core Domains in Evaluating Patient Outcomes After Acute Respiratory Failure: International Multidisciplinary Clinician Consultation"],"prefix":"10.1093","volume":"97","author":[{"given":"Carol L.","family":"Hodgson","sequence":"first","affiliation":[{"name":"C.L. Hodgson, PhD, Department of Epidemiology and Preventive Medicine, Monash University, 99 Commercial Rd, Melbourne, Victoria 3004, Australia, and Department of Physiotherapy, Alfred Hospital, Melbourne, Victoria, Australia. Address all correspondence to Dr Hodgson at: carol.hodgson@monash.edu."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison E.","family":"Turnbull","sequence":"additional","affiliation":[{"name":"A.E. Turnbull, DVM, PhD, MPH, Outcomes After Critical Illness and Surgery (OACIS), Johns Hopkins University, Baltimore, Maryland; Division of Pulmonary and Critical Care Medicine, Johns Hopkins University; and Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theodore J.","family":"Iwashyna","sequence":"additional","affiliation":[{"name":"T.J. Iwashyna, MD, PhD, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan; Center for Clinical Management Research, VA Ann Arbor Healthcare System, Ann Arbor, Michigan; and Department of Epidemiology and Preventive Medicine, Monash University."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann","family":"Parker","sequence":"additional","affiliation":[{"name":"A. Parker, MD, Outcomes After Critical Illness and Surgery (OACIS), Johns Hopkins University, and Division of Pulmonary and Critical Care Medicine, Johns Hopkins University."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wesley","family":"Davis","sequence":"additional","affiliation":[{"name":"W. Davis, BA, Outcomes After Critical Illness and Surgery (OACIS), Johns Hopkins University, and Division of Pulmonary and Critical Care Medicine, Johns Hopkins University."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"III","given":"Clifton O.","family":"Bingham","sequence":"additional","affiliation":[{"name":"C.O. Bingham III, MD, Division of Rheumatology, Johns Hopkins University, and Division of Allergy and Clinical Immunology, Johns Hopkins University."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola R.","family":"Watts","sequence":"additional","affiliation":[{"name":"N.R. Watts, PhD, Division of Critical Care and Trauma, The George Institute for Global Health, Sydney, New South Wales, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Finfer","sequence":"additional","affiliation":[{"name":"S. Finfer, MD, Division of Critical Care and Trauma, The George Institute for Global Health, and Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dale M.","family":"Needham","sequence":"additional","affiliation":[{"name":"D.M. Needham, MD, PhD, Outcomes After Critical Illness and Surgery (OACIS), Johns Hopkins University; Division of Pulmonary and Critical Care Medicine, Johns Hopkins University; and Department of Physical Medicine and Rehabilitation, Johns Hopkins University."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2016,10,6]]},"reference":[{"key":"2023011704463959400_bib1","doi-asserted-by":"crossref","first-page":"e000133","DOI":"10.1136\/bmjresp-2016-000133","article-title":"British Thoracic Society\/Intensive Care Society guideline for the ventilatory management of acute hypercapnic respiratory failure in adults","volume":"3","author":"Davidson","year":"2016","journal-title":"BMJ Open Respir Res"},{"key":"2023011704463959400_bib2","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.apmr.2010.01.002","article-title":"Early physical medicine and rehabilitation for patients with acute respiratory failure: a quality improvement project","volume":"91","author":"Needham","year":"2010","journal-title":"Arch Phys Med Rehabil"},{"key":"2023011704463959400_bib3","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.mpaic.2015.10.004","article-title":"Intensive care unit acquired weakness","volume":"17","author":"Hodgson","year":"2016","journal-title":"Anaesthesia and Intensive Care Medicine"},{"key":"2023011704463959400_bib4","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1056\/NEJMoa1011802","article-title":"Functional disability 5 years after acute respiratory distress syndrome","volume":"364","author":"Herridge","year":"2011","journal-title":"N Engl J Med"},{"key":"2023011704463959400_bib5","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1097\/CCM.0b013e318232da75","article-title":"Improving long-term outcomes after discharge from intensive care unit: report from a stakeholders\u2019 conference","volume":"40","author":"Needham","year":"2012","journal-title":"Crit Care Med"},{"key":"2023011704463959400_bib6","doi-asserted-by":"crossref","first-page":"204","DOI":"10.7326\/0003-4819-153-3-201008030-00013","article-title":"Survivorship will be the defining challenge of critical care in the 21st century","volume":"153","author":"Iwashyna","year":"2010","journal-title":"Ann Intern Med"},{"key":"2023011704463959400_bib7","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1007\/s00134-002-1624-8","article-title":"Surviving intensive care: a report from the 2002 Brussels Roundtable","volume":"29","author":"Angus","year":"2003","journal-title":"Intensive Care Med"},{"key":"2023011704463959400_bib8","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1007\/s00134-006-0217-3","article-title":"Quality of life after acute respiratory distress syndrome: a meta-analysis","volume":"32","author":"Dowdy","year":"2006","journal-title":"Intensive Care Med"},{"key":"2023011704463959400_bib9","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1055\/s-0032-1321982","article-title":"The burdens of survivorship: an approach to thinking about long-term outcomes after critical illness","volume":"33","author":"Iwashyna","year":"2012","journal-title":"Semin Respir Crit Care Med"},{"key":"2023011704463959400_bib10","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1097\/CCM.0b013e3181f3dec5","article-title":"Quality of life after intensive care: a systematic review of the literature","volume":"38","author":"Oeyen","year":"2010","journal-title":"Crit Care Med"},{"key":"2023011704463959400_bib11","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1097\/CCM.0000000000001651","article-title":"Outcome measurement in ICU survivorship research from 1970 to 2013: a scoping review of 425 publications","volume":"44","author":"Turnbull","year":"2016","journal-title":"Crit Care Med"},{"key":"2023011704463959400_bib12","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1097\/MCC.0000000000000232","article-title":"Progress on core outcome sets for critical care research","volume":"21","author":"Blackwood","year":"2015","journal-title":"Curr Opin Crit Care"},{"key":"2023011704463959400_bib13","article-title":"Improving long-term outcomes research for acute respiratory failure","author":"Initiative COMET"},{"key":"2023011704463959400_bib14","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1186\/s13063-015-0905-9","article-title":"Core Outcomes in Ventilation Trials (COVenT): protocol for a core outcome set using a Delphi survey with a nested randomised trial and observational cohort study","volume":"16","author":"Blackwood","year":"2015","journal-title":"Trials"},{"key":"2023011704463959400_bib15","doi-asserted-by":"crossref","first-page":"e1000393","DOI":"10.1371\/journal.pmed.1000393","article-title":"Using the Delphi technique to determine which outcomes to measure in clinical trials: recommendations for the future based on a systematic review of existing studies","volume":"8","author":"Sinha","year":"2011","journal-title":"PLoS Med"},{"key":"2023011704463959400_bib16","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1097\/MLR.0000000000000413","article-title":"Confirmatory factor analysis of the Patient-Reported Outcomes Measurement Information System (PROMIS) adult domain framework using item response theory scores","volume":"53","author":"Carle","year":"2015","journal-title":"Med Care"},{"key":"2023011704463959400_bib17","volume-title":"International Classification of Functioning, Disability and Health (ICF)","year":"2001"},{"key":"2023011704463959400_bib18","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1046\/j.1365-2648.2000.t01-1-01567.x","article-title":"Research guidelines for the Delphi survey technique","volume":"32","author":"Hasson","year":"2000","journal-title":"J Adv Nurs"},{"key":"2023011704463959400_bib19","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","article-title":"Research Electronic Data Capture (REDCap): a metadata-driven methodology and workflow process for providing translational research informatics support","volume":"42","author":"Harris","year":"2009","journal-title":"J Biomed Inform"},{"key":"2023011704463959400_bib20","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1186\/1745-6215-13-132","article-title":"Developing core outcome sets for clinical trials: issues to consider","volume":"13","author":"Williamson","year":"2012","journal-title":"Trials"},{"key":"2023011704463959400_bib21","first-page":"302","article-title":"A systematic review of measurements of physical function in critically ill adults","volume":"14","author":"Tipping","year":"2012","journal-title":"Crit Care Resusc"},{"key":"2023011704463959400_bib22","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1007\/s00134-015-3672-x","article-title":"Assessment of impairment and activity limitations in the critically ill: a systematic review of measurement instruments and their clinimetric properties","volume":"41","author":"Parry","year":"2015","journal-title":"Intensive Care Med"},{"key":"2023011704463959400_bib23","first-page":"153","article-title":"Persistent critical illness characterised by Australian and New Zealand ICU clinicians","volume":"17","author":"Iwashyna","year":"2015","journal-title":"Crit Care Resusc"},{"key":"2023011704463959400_bib24","doi-asserted-by":"crossref","first-page":"569","DOI":"10.3899\/jrheum.131246","article-title":"OMERACT endorsement of measures of outcome for studies of acute gout","volume":"41","author":"Singh","year":"2014","journal-title":"J Rheumatol"},{"key":"2023011704463959400_bib25","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1136\/bmj.311.7001.376","article-title":"Consensus methods for medical and health services research","volume":"311","author":"Jones","year":"1995","journal-title":"BMJ"}],"container-title":["Physical Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ptj\/article-pdf\/97\/2\/168\/48725973\/ptj_97_2_168.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ptj\/article-pdf\/97\/2\/168\/48725973\/ptj_97_2_168.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T02:16:34Z","timestamp":1749608194000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ptj\/article\/97\/2\/168\/2996710"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,6]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2,1]]}},"URL":"https:\/\/doi.org\/10.2522\/ptj.20160196","relation":{},"ISSN":["0031-9023","1538-6724"],"issn-type":[{"value":"0031-9023","type":"print"},{"value":"1538-6724","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,2]]},"published":{"date-parts":[[2016,10,6]]}}}