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Immunocytochemistry is a helpful aid to cytologic evaluation for the former. The distinction of reactive mesothelial cells from mesothelioma can be more difficult, as there is considerable overlap in their appearances in effusion specimens. Recently developed ancillary molecular and genetic tests are proving to be useful in confirming the diagnosis of malignant mesothelioma in cytology specimens.<\/jats:p>","DOI":"10.25259\/cmas_02_08_2021","type":"journal-article","created":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T05:15:15Z","timestamp":1646111715000},"page":"10","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Mesothelioma"],"prefix":"10.25259","volume":"19","author":[{"given":"Nagarjun","family":"Rao","sequence":"first","affiliation":[{"name":"Department of Pathology, Great Lakes Pathologists\/Aurora Clinical Laboratories, Aurora West Allis Medical Center, West Allis, Wisconsin, United States,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuanzeng","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Pathology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2022,2,28]]},"reference":[{"key":"10.25259\/CMAS_02_08_2021\/ref-1","first-page":"313","article-title":"Clinical presentation and natural history of benign and malignant mesothelioma","volume":"8","author":"Antman","year":"1981","journal-title":"Semin Oncol"},{"key":"10.25259\/CMAS_02_08_2021\/ref-2","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1136\/oem.17.4.260","article-title":"Diffuse pleural mesothelioma and asbestos exposure in the North Western Cape Province","volume":"17","author":"Wagner","year":"1960","journal-title":"Br J Ind Med"},{"key":"10.25259\/CMAS_02_08_2021\/ref-3","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1038\/ng.3520","article-title":"Comprehensive genomic analysis of malignant pleural mesothelioma identifies recurrent mutations, gene fusions and splicing alterations","volume":"48","author":"Bueno","year":"2016","journal-title":"Nat Genet"},{"issue":"6 Pt 1","key":"10.25259\/CMAS_02_08_2021\/ref-4","doi-asserted-by":"publisher","first-page":"746","DOI":"10.7326\/0003-4819-96-6-746","article-title":"Diffuse malignant mesothelioma. 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