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This specific mutation is associated with constitutive activation of the c-KIT, which is crucial in the pathogenesis of GIST. Such unique histological characteristics broaden our understanding of the morphological diversity within GISTs and underscore the importance of considering an extended differential diagnosis when encountering atypical gastrointestinal tumors. This rare presentation may challenge conventional diagnostic criteria and could influence therapeutic strategies, emphasizing the need for comprehensive histological and molecular assessments in patient management.<\/jats:p>","DOI":"10.25259\/cytojournal_104_2024","type":"journal-article","created":{"date-parts":[[2024,11,23]],"date-time":"2024-11-23T11:49:33Z","timestamp":1732362573000},"page":"51","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Gastrointestinal stromal tumor mimicking perineurioma: A case report"],"prefix":"10.25259","volume":"21","author":[{"given":"Yu","family":"Pan","sequence":"first","affiliation":[{"name":"School of Clinical Medicine, Shandong Second Medical University, Weifang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Gao","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine, Shandong Second Medical University, Weifang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Affiliated Yantai Yuhuangding Hospital, Qingdao University, Yantai, China,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guohua","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Affiliated Yantai Yuhuangding Hospital, Qingdao University, Yantai, China,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2024,11,23]]},"reference":[{"key":"10.25259\/Cytojournal_104_2024\/ref-1","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1038\/modpathol.2008.2","article-title":"Clinicopathologic profile of gastrointestinal stromal tumors (GISTs) with primary KIT exon 13 or exon 17 mutations: A multicenter study on 54 cases","volume":"21","author":"Lasota","year":"2008","journal-title":"Mod Pathol"},{"key":"10.25259\/Cytojournal_104_2024\/ref-2","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1038\/s41572-021-00254-5","article-title":"Gastrointestinal stromal tumours","volume":"7","author":"Blay","year":"2021","journal-title":"Nat Rev Dis Primers"},{"key":"10.25259\/Cytojournal_104_2024\/ref-3","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1097\/PAS.0b013e3181a13e99","article-title":"Gastrointestinal stromal tumors presenting as omental masses--a clinicopathologic analysis of 95 cases","volume":"33","author":"Miettinen","year":"2009","journal-title":"Am J Surg Pathol"},{"key":"10.25259\/Cytojournal_104_2024\/ref-4","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1053\/j.semdp.2006.09.001","article-title":"Gastrointestinal stromal tumors: Pathology and prognosis at different sites","volume":"23","author":"Miettinen","year":"2006","journal-title":"Semin Diagn Pathol"},{"key":"10.25259\/Cytojournal_104_2024\/ref-5","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1001\/jamaoncol.2016.0256","article-title":"Molecular subtypes of KIT\/PDGFRA wild-type gastrointestinal stromal tumors: A report from the national institutes of health gastrointestinal stromal tumor Clinic","volume":"2","author":"Boikos","year":"2016","journal-title":"JAMA Oncol"},{"key":"10.25259\/Cytojournal_104_2024\/ref-6","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1111\/j.1365-2559.2006.02514.x","article-title":"Quantification of immunohistochemistry--issues concerning methods, utility and semiquantitative assessment I","volume":"49","author":"Walker","year":"2006","journal-title":"Histopathology"},{"key":"10.25259\/Cytojournal_104_2024\/ref-7","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1111\/j.1440-1827.2008.02335.x","article-title":"Gastrointestinal stromal tumor in the duodenum exhibiting hemangiopericytoma-like histological pattern","volume":"59","author":"Takahashi","year":"2009","journal-title":"Pathol Int"},{"key":"10.25259\/Cytojournal_104_2024\/ref-8","first-page":"150","article-title":"Gastrointestinal stromal tumor (GIST) with glandular component. 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