{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T08:10:08Z","timestamp":1767859808578,"version":"3.49.0"},"reference-count":13,"publisher":"Scientific Scholar","content-domain":{"domain":["cytojournal.com"],"crossmark-restriction":true},"short-container-title":["Cytojournal"],"abstract":"<jats:p>A 51-year-old male with a history of chronic myelomonocytic leukemia-2 (CMML-2) presented with fatigue, night sweats, dyspnea, and right-sided chest pain exacerbated by deep breath. Computed tomography scan demonstrated right-sided pleural effusion with atelectasis. Pleural fluid cytology showed reactive mesothelial cells mixed with atypical cells [Figure 1]. The immunostains are performed using the SCIP approach.<jats:sup>[1]<\/jats:sup> The atypical cells were immunoreactive for vimentin, CD68, and CD163, while non-immunoreactive for cytokeratin, calretinin, BerEP4, and MOC31.<\/jats:p>","DOI":"10.25259\/cytojournal_12_2020","type":"journal-article","created":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T05:40:41Z","timestamp":1613972441000},"page":"3","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Pleural effusion in hematological pathology"],"prefix":"10.25259","volume":"18","author":[{"given":"Neeraja","family":"Yerrapotu","sequence":"first","affiliation":[{"name":"Department of Pathology, Detroit Medical Center, Karmanos Cancer Center and Wayne State University School of Medicine, Detroit, Michigan, United States,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abid","family":"Rahman","sequence":"additional","affiliation":[{"name":"Department of Pathology, Detroit Medical Center, Karmanos Cancer Center and Wayne State University School of Medicine, Detroit, Michigan, United States,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Gabali","sequence":"additional","affiliation":[{"name":"Department of Pathology, Detroit Medical Center, Karmanos Cancer Center and Wayne State University School of Medicine, Detroit, Michigan, United States,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinod B","family":"Shidham","sequence":"additional","affiliation":[{"name":"Department of Pathology, Detroit Medical Center, Karmanos Cancer Center and Wayne State University School of Medicine, Detroit, Michigan, United States,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2021,2,22]]},"reference":[{"key":"10.25259\/Cytojournal_12_2020\/ref-1","first-page":"55","volume-title":"Cytopathologic Diagnosis of Serous Fluids","year":"2007","edition":"1st ed"},{"key":"10.25259\/Cytojournal_12_2020\/ref-2","first-page":"171","volume-title":"Cytopathological Diagnosis of Serous Fluids","author":"Sanchez","year":"2007"},{"key":"10.25259\/Cytojournal_12_2020\/ref-3","doi-asserted-by":"publisher","first-page":"1536","DOI":"10.1038\/modpathol.3800707","article-title":"Chronic myelomonocytic leukemia: The role of bone marrow biopsy immunohistology","volume":"19","author":"Orazi","year":"2006","journal-title":"Mod Pathol"},{"key":"10.25259\/Cytojournal_12_2020\/ref-4","doi-asserted-by":"publisher","first-page":"3080","DOI":"10.1182\/blood-2012-01-404863","article-title":"SRSF2 mutations in 275 Cases with chronic myelomonocytic leukemia (CMML)","volume":"120","author":"Meggendorfer","year":"2012","journal-title":"Blood"},{"key":"10.25259\/Cytojournal_12_2020\/ref-5","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1309\/HRJ1XKTD77J1UTFM","article-title":"Flow cytometric analysis of monocytes as a tool for distinguishing chronic myelomonocytic leukemia from reactive monocytosis","volume":"124","author":"Xu","year":"2005","journal-title":"Am J Clin Pathol"},{"key":"10.25259\/Cytojournal_12_2020\/ref-6","doi-asserted-by":"crossref","first-page":"3005","DOI":"10.1182\/blood-2012-08-452938","article-title":"Development and validation of a prognostic scoring system for patients with chronic myelomonocytic leukemia","volume":"121","author":"Such","year":"2013","journal-title":"Blood"},{"key":"10.25259\/Cytojournal_12_2020\/ref-7","doi-asserted-by":"publisher","first-page":"1332","DOI":"10.1080\/10428194.2017.1387913","article-title":"Cytogenetic risk stratification may predict allogeneic hematopoietic stem cell transplantation outcomes for chronic myelomonocytic leukemia","volume":"59","author":"Motohashi","year":"2018","journal-title":"Leuk Lymphoma"},{"key":"10.25259\/Cytojournal_12_2020\/ref-8","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1159\/000040713","article-title":"Pleural effusion in chronic myelomonocytic leukemia","volume":"99","author":"Bourantas","year":"1998","journal-title":"Acta Haematol"},{"key":"10.25259\/Cytojournal_12_2020\/ref-9","doi-asserted-by":"publisher","first-page":"617","DOI":"10.3109\/10428199809050922","article-title":"Dramatic resolution of pleural effusion in children with chronic myelomonocytic leukemia following short-course high-dose methylprednisolone","volume":"29","author":"Hi\u00e7s\u00f6nmez","year":"1998","journal-title":"Leuk Lymphoma"},{"key":"10.25259\/Cytojournal_12_2020\/ref-10","first-page":"546","article-title":"Pleural involvement in the course of chronic myelomonocytic leukemia and the development of multiple colonic perforation due to leukemic infiltration in the acute leukemia phase","volume":"45","author":"Watanabe","year":"2004","journal-title":"Rinsho Ketsueki"},{"key":"10.25259\/Cytojournal_12_2020\/ref-11","first-page":"217","article-title":"Chronic myelomonocytic leukemia with pleural effusion as the first clinical sign","volume":"46","author":"Yamazaki","year":"2005","journal-title":"Rinsho Ketsueki"},{"key":"10.25259\/Cytojournal_12_2020\/ref-12","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1002\/ccr3.55","article-title":"Chronic myelomonocytic leukemia presenting with polyserositis due to an immune-mediated monocyte activation","volume":"2","author":"Imataki","year":"2014","journal-title":"Clin Case Rep"},{"key":"10.25259\/Cytojournal_12_2020\/ref-13","first-page":"1223","article-title":"Chronic myelomonocytic leukemia with myelofibrosis resulting in sudden massive pleural effusion during cytoreductive therapy with hydroxycarbamide","volume":"43","author":"Sunami","year":"2016","journal-title":"Gan To Kagaku Ryoho"}],"container-title":["Cytojournal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cytojournal.com\/pleural-effusion-in-hematological-pathology\/","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cytojournal.com\/pleural-effusion-in-hematological-pathology\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T05:40:46Z","timestamp":1613972446000},"score":1,"resource":{"primary":{"URL":"https:\/\/cytojournal.com\/pleural-effusion-in-hematological-pathology\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,22]]},"references-count":13,"alternative-id":["10.25259\/Cytojournal_12_2020"],"URL":"https:\/\/doi.org\/10.25259\/cytojournal_12_2020","relation":{},"ISSN":["0974-5963"],"issn-type":[{"value":"0974-5963","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,22]]},"article-number":"3"}}