{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T20:18:56Z","timestamp":1784319536646,"version":"3.55.0"},"reference-count":22,"publisher":"Scientific Scholar","content-domain":{"domain":["cytojournal.com"],"crossmark-restriction":true},"short-container-title":["Cytojournal"],"abstract":"<jats:sec id=\"st1\">\n<jats:title>Objective:<\/jats:title>\n<jats:p>Histopathology examination is important for diagnosing autoimmune pancreatitis (AIP), which is suspected to be pancreatic cancer based on imaging findings. Although the validity of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) in the diagnosis of AIP is still debated globally, this study aimed to evaluate the efficacy of EUS-FNA in the diagnosis of AIP with suspected pancreatic cancer.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st2\">\n<jats:title>Material and Methods:<\/jats:title>\n<jats:p>From January 2021 to June 2024, 30 AIP patients with radiographically diagnosed pancreatic cancer were enrolled and underwent EUS-FNA. Sex, age, symptoms, CA199, serum immunoglobulin G4 (IgG4), and treatment outcome were included. Tissue sampling conditions, puncture sites, storiform fibrosis, CD38- and IgG4-positive plasma cell counts, and obliterans phlebitis were evaluated.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st3\">\n<jats:title>Results:<\/jats:title>\n<jats:p>Thirty patients, 24 males and six females, with an average age of 60.53 \u00b1 11.72 years (32-79 years), were included in the study. Thirty patients had their serum IgG4 and CA199 levels tested. Tissue samples containing \u226510 were obtained from 19 (63.33%) patients. CD38+ plasma cell infiltration and laminar fibrosis were detected in 22 (73.33%) and 10 (33.33%) patients. According to the International Consensus Diagnostic Criteria ( ICDC), 12 patients had histopathological levels of Grade 1, 15 of Grade 2, and three patients could not be classified. The accuracy, sensitivity, and specificity of EUS-FNA in diagnosing AIP with suspected pancreatic cancer on imaging were 96.66% (29\/30), 96.42% (27\/28), and 100% (2\/2), respectively. The area under the curve value of EUS-FNA for patients with AIP who were radiologically suspected of having pancreatic cancer was 0.957.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st4\">\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>Approximately 90% of patients with EUS-FNA results are diagnosed with an ICDC level of 2 or higher. Our results suggest that for cases where malignant tumors are suspected after imaging or cannot be ruled out, obtaining pancreatic tissue through EUS-FNA puncture for pathological diagnosis is recommended.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/cytojournal_214_2024","type":"journal-article","created":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T06:15:24Z","timestamp":1748844924000},"page":"58","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Endoscopic ultrasound-guided fine-needle aspiration value in suspected autoimmune pancreatitis malignancy diagnosis"],"prefix":"10.25259","volume":"22","author":[{"given":"Yue","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Changhai Hospital, Second\/Navy Military Medical University, Shanghai, 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