{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T00:05:41Z","timestamp":1755907541463,"version":"3.44.0"},"reference-count":8,"publisher":"Scientific Scholar","content-domain":{"domain":["cytojournal.com"],"crossmark-restriction":true},"short-container-title":["Cytojournal"],"abstract":"<jats:p>Primary effusion lymphoma (PEL) is a rare kind of extranodal non-Hodgkin large B-cell lymphoma that develops in the liquid phase in serous membrane-lined body cavities (perineum, pericardium, and pleura) without tumor masses. Kaposi sarcoma-associated human herpesvirus 8 (HHV8) is essential in establishing a diagnosis of PEL. An 84-year-old male with a past medical history of testicular cancer in his 40s presented with a chief complaint of shortness of breath which was attributed to a left pleural effusion. The flow cytometry indicated 32% small T lymphocytes (cluster of differentiation [CD]4: CD8 = 4.0:1), 9.0% small B lymphocytes without surface light chain expression, and 16% unknown phenotypic large cells. The cell block demonstrated large atypical lymphocytes with irregular nuclear membranes and coarse chromatin. The cells exhibited prominent nucleoli and relatively basophilic, abundant amphophilic cytoplasm. Multinucleated and Reed\u2013Sternberg-like cells were also seen. We performed a panel of immunomarkers including HHV8 and ALK1. The tumor cells were positive for CD45, CD20, and HHV8 and negative for all other markers. Based on morphologic and immunophenotypical features, a diagnosis of PEL is rendered. Positron emission tomography\/computed tomography showed an absence of fluorodeoxyglucose uptake in the lymph nodes and the spleen. Given his age, the patient started on treatment with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone at reduced doses (R-miniCHOP) and had a complete response. To our knowledge, there are no other reported cases of complete remission following an attenuated R-miniCHOP protocol in this clinical scenario.<\/jats:p>","DOI":"10.25259\/cytojournal_267_2024","type":"journal-article","created":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T06:18:28Z","timestamp":1755843508000},"page":"77","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Human immunodeficiency virus negative, immunocompetent primary effusion lymphoma with a complete response on R-miniCHOP"],"prefix":"10.25259","volume":"22","author":[{"given":"Momin","family":"Iqbal","sequence":"first","affiliation":[{"name":"Department of Pathology, NYU Grossman Long Island School of Medicine, Mineola, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Vaughn","sequence":"additional","affiliation":[{"name":"Department of Medicine, NYU Grossman Long Island School of Medicine, Mineola, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Radiology, NYU Grossman Long Island School of Medicine, Mineola, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pathology, NYU Grossman School of Medicine, New York, United States,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianhong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pathology, NYU Grossman Long Island School of Medicine, Mineola, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2025,8,22]]},"reference":[{"key":"10.25259\/Cytojournal_267_2024\/ref-1","doi-asserted-by":"publisher","first-page":"3747","DOI":"10.2147\/OTT.S167392","article-title":"Primary effusion lymphoma: Current perspectives","volume":"11","author":"Narkhede","year":"2018","journal-title":"Onco Targets Ther"},{"key":"10.25259\/Cytojournal_267_2024\/ref-2","doi-asserted-by":"publisher","first-page":"e2022020","DOI":"10.4084\/MJHID.2022.020","article-title":"Classic KSHV\/HHV-8-positive primary effusion lymphoma (PEL): A systematic review and meta-analysis of case reports","volume":"14","author":"Cozzi","year":"2022","journal-title":"Mediterr J Hematol Infect Dis"},{"key":"10.25259\/Cytojournal_267_2024\/ref-3","doi-asserted-by":"publisher","first-page":"2093","DOI":"10.1080\/10428194.2020.1762881","article-title":"Clinicopathologic characteristics and survival of patients with primary effusion lymphoma","volume":"61","author":"Aguilar","year":"2020","journal-title":"Leuk Lymphoma"},{"key":"10.25259\/Cytojournal_267_2024\/ref-4","doi-asserted-by":"publisher","first-page":"713","DOI":"10.3390\/diagnostics12030713","article-title":"Primary effusion lymphoma: A timely review on the association with HIV, HHV8, and EBV","volume":"12","author":"Liu","year":"2022","journal-title":"Diagnostics (Basel)"},{"key":"10.25259\/Cytojournal_267_2024\/ref-5","doi-asserted-by":"publisher","first-page":"1879","DOI":"10.1182\/blood-2018-03-791426","article-title":"Biology and management of primary effusion lymphoma","volume":"132","author":"Shimada","year":"2018","journal-title":"Blood"},{"key":"10.25259\/Cytojournal_267_2024\/ref-6","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1186\/s12885-021-08215-7","article-title":"Primary effusion lymphoma occurring in the setting of transplanted patients: A systematic review of a rare, life-threatening post-transplantation occurrence","volume":"21","author":"Zanelli","year":"2021","journal-title":"BMC Cancer"},{"key":"10.25259\/Cytojournal_267_2024\/ref-7","doi-asserted-by":"publisher","first-page":"370","DOI":"10.3390\/diagnostics13030370","article-title":"Primary effusion lymphoma: A rare and challenging diagnosis for recurrent pleural effusion","volume":"13","author":"Pereira","year":"2023","journal-title":"Diagnostics (Basel)"},{"key":"10.25259\/Cytojournal_267_2024\/ref-8","doi-asserted-by":"publisher","first-page":"e485","DOI":"10.1016\/j.clml.2022.01.006","article-title":"Clinical characteristics and survival outcomes of primary effusion lymphoma: A national cancer database study","volume":"22","author":"Baidoun","year":"2022","journal-title":"Clin Lymphoma Myeloma Leuk"}],"container-title":["Cytojournal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cytojournal.com\/human-immunodeficiency-virus-negative-immunocompetent-primary-effusion-lymphoma-with-a-complete-response-on-r-minichop\/","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cytojournal.com\/human-immunodeficiency-virus-negative-immunocompetent-primary-effusion-lymphoma-with-a-complete-response-on-r-minichop\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T06:18:28Z","timestamp":1755843508000},"score":1,"resource":{"primary":{"URL":"https:\/\/cytojournal.com\/human-immunodeficiency-virus-negative-immunocompetent-primary-effusion-lymphoma-with-a-complete-response-on-r-minichop\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,22]]},"references-count":8,"alternative-id":["10.25259\/Cytojournal_267_2024"],"URL":"https:\/\/doi.org\/10.25259\/cytojournal_267_2024","relation":{},"ISSN":["1742-6413","0974-5963"],"issn-type":[{"value":"1742-6413","type":"electronic"},{"value":"0974-5963","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8,22]]},"article-number":"77"}}