{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T11:23:01Z","timestamp":1776424981786,"version":"3.51.2"},"reference-count":25,"publisher":"Scientific Scholar","content-domain":{"domain":["cytojournal.com"],"crossmark-restriction":true},"short-container-title":["Cytojournal"],"abstract":"\nObjectives:<\/jats:title>\nThe hyalinizing trabecular tumor (HTT) is a rare benign neoplasm of the thyroid gland. This neoplasm has overlapping cytological features with Papillary Thyroid Carcinoma, Medullary Carcinoma and Follicular Neoplasm with Nuclear Features of Papillary Carcinoma. This can lead to misdiagnosis of malignancy in fine needle aspiration (FNA) cytology specimens with unnecessary total thyroidectomy. The aim of this study is to determine if there are some cytological features that could help us to suspect HTT on FNA specimens and avoid radical surgery.<\/jats:p>\n<\/jats:sec>\n\nMaterial and Methods:<\/jats:title>\nWith this purpose we have collected 6 cases diagnosed of HTT in Hospital Cl\u00ednico San Carlos of Madrid (Spain) in the last 10 years and reviewed the cytological specimens.<\/jats:p>\n<\/jats:sec>\n\nResult:<\/jats:title>\nWe conclude that the presence of hyaline material in FNA specimens of HTT is a constant feature being a diagnostic clue. We must be cautious not to confuse it with dense colloid or amyloid material, the latter seen in Medullary Carcinoma. Papillary architecture and fibrovascular cores are not present in a HTT. Special stains as ki-67, calcitonin and Congo Red staining could help us in achieving the correct diagnosis.<\/jats:p>\n<\/jats:sec>\n\nConclusion:<\/jats:title>\nWe feel the cytopathologists must be aware of the distinguishing features of this lesion, mainly the typical hyaline material to achieve a proper diagnosis and be able to reduce unnecessary aggressive management of these patients.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/cytojournal_34_2023","type":"journal-article","created":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T15:46:50Z","timestamp":1693324010000},"page":"19","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Diagnostic clues for hyalinizing trabecular tumor on fine needle aspiration cytology"],"prefix":"10.25259","volume":"20","author":[{"given":"Lone","family":"Nielsen","sequence":"first","affiliation":[{"name":"Department of Pathology, Hospital Cl\u00ednico San Carlos, Madrid, Spain,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Mar\u00eda Colino","family":"Gallardo","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hospital Cl\u00ednico San Carlos, Madrid, Spain,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo P\u00e9rez","family":"Alonso","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hospital Cl\u00ednico San Carlos, Madrid, Spain,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis Ortega","family":"Medina","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hospital Cl\u00ednico San Carlos, Madrid, Spain,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esthefan\u00eda Latorre","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hospital General Universitario Nuestra Se\u00f1ora del Prado, Talavera de la Reina, Spain,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina D\u00edaz","family":"del Arco","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hospital Cl\u00ednico San Carlos, Madrid, Spain,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reyes Bergillos","family":"Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hospital Cl\u00ednico San Carlos, Madrid, Spain,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo Alarc\u00f3n","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hospital Cl\u00ednico San Carlos, Madrid, Spain,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta Cruz","family":"Blanco","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hospital Cl\u00ednico San Carlos, Madrid, Spain,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jes\u00fas Vega","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hospital Cl\u00ednico San Carlos, Madrid, Spain,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Montserrat De la Torre","family":"Serrano","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hospital Cl\u00ednico San Carlos, Madrid, Spain,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Jes\u00fas","family":"Fern\u00e1ndez-Ace\u00f1ero","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hospital Cl\u00ednico San Carlos, Madrid, Spain,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2023,8,29]]},"reference":[{"key":"10.25259\/Cytojournal_34_2023\/ref-1","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1097\/00000478-198708000-00001","article-title":"Hyalinizing trabecular adenoma of the thyroid gland","volume":"11","author":"Carney","year":"1987","journal-title":"Am J Surg Pathol"},{"key":"10.25259\/Cytojournal_34_2023\/ref-2","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1136\/jclinpath-2017-204360","article-title":"Hyalinizing trabecular tumour of the thyroid: Fine-needle aspiration cytological diagnosis and correlation with histology","volume":"70","author":"Scaglietti","year":"2017","journal-title":"J Clin Pathol"},{"key":"10.25259\/Cytojournal_34_2023\/ref-3","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1111\/j.1365-2303.2011.00886.x","article-title":"Diagnostic dilemmas of hyalinizing trabecular tumours on fine needle aspiration cytology: A study of seven cases with BRAF mutation analysis","volume":"22","author":"Kim","year":"2011","journal-title":"Cytopathology"},{"key":"10.25259\/Cytojournal_34_2023\/ref-4","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1159\/000355291","article-title":"Hyalinizing trabecular tumor masquerading as papillary thyroid carcinoma on fine-needle aspiration","volume":"75","author":"Howard","year":"2014","journal-title":"ORL J Otorhinolaryngol Relat Spec"},{"key":"10.25259\/Cytojournal_34_2023\/ref-5","doi-asserted-by":"publisher","first-page":"131","DOI":"10.14366\/usg.15054","article-title":"Hyalinizing trabecular tumor of the hyroid: Diagnosis of a rare tumor using ultrasonography, cytology, and intraoperative frozen sections","volume":"35","author":"Jang","year":"2016","journal-title":"Ultrasonography"},{"key":"10.25259\/Cytojournal_34_2023\/ref-6","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s13044-017-0042-5","article-title":"Hyalinizing trabecular tumor of the thyroid gland and its significant diagnostic issue","volume":"10","author":"Jones","year":"2017","journal-title":"Thyroid Res"},{"key":"10.25259\/Cytojournal_34_2023\/ref-7","doi-asserted-by":"publisher","first-page":"252","DOI":"10.4132\/jptm.2018.04.28","article-title":"Hyalinizing trabecular tumor of the thyroid gland, a diagnostic challenge in fine-needle aspiration cytology: Case report","volume":"52","author":"Rhee","year":"2018","journal-title":"J Pathol Transl Med"},{"key":"10.25259\/Cytojournal_34_2023\/ref-8","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1007\/BF03346734","article-title":"Cytological diagnosis difficulties in hyalinizing trabecular adenoma of the thyroid","volume":"34","author":"Arena","year":"2011","journal-title":"J Endocrinol Invest"},{"key":"10.25259\/Cytojournal_34_2023\/ref-9","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1002\/(SICI)1097-0339(199902)20:2<90::AID-DC10>3.0.CO;2-N","article-title":"Fine-needle aspiration biopsy cytology of hyalinizing trabecular adenomas of the thyroid","volume":"20","author":"Akin","year":"1999","journal-title":"Diagn Cytopathol"},{"key":"10.25259\/Cytojournal_34_2023\/ref-10","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/1742-6413-3-17","article-title":"Lack of BRAF mutations in hyalinizing trabecular neoplasm","volume":"25","author":"Baloch","year":"2006","journal-title":"Cytojournal"},{"key":"10.25259\/Cytojournal_34_2023\/ref-11","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1159\/000326540","article-title":"Cytologic features of hyalinizing trabecular adenoma of the thyroid","volume":"47","author":"Kuma","year":"2003","journal-title":"Acta Cytol"},{"key":"10.25259\/Cytojournal_34_2023\/ref-12","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1002\/dc.2840100107","article-title":"Clue helping to distinguish hyalinizing trabecular adenoma from carcinoma of the thyroid in fine-needle aspirates","volume":"10","author":"Bondeson","year":"1994","journal-title":"Diagn Cytopathol"},{"key":"10.25259\/Cytojournal_34_2023\/ref-13","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1093\/ajcp\/91.2.115","article-title":"Cytologic features of fine-needle aspirates of hyalinizing trabecular adenoma of the thyroid","volume":"91","author":"Goellner","year":"1989","journal-title":"Am J Clin Pathol"},{"key":"10.25259\/Cytojournal_34_2023\/ref-14","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-60570-8","article-title":"The Bethesda System for Reporting Thyroid Cytopathology","author":"Ali","year":"2018","edition":"2nd ed"},{"key":"10.25259\/Cytojournal_34_2023\/ref-15","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1001\/jamaoncol.2016.0386","article-title":"Nomenclature revision for encapsulated follicular variant of papillary thyroid carcinoma: A paradigm shift to reduce overtreatment of indolent tumors","volume":"2","author":"Nikiforov","year":"2016","journal-title":"JAMA Oncol"},{"key":"10.25259\/Cytojournal_34_2023\/ref-16","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1309\/AJCPEIE12POICULI","article-title":"Fine-needle aspiration diagnoses of noninvasive follicular variant of papillary thyroid carcinoma","volume":"144","author":"Howitt","year":"2015","journal-title":"Am J Clin Pathol"},{"key":"10.25259\/Cytojournal_34_2023\/ref-17","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1002\/cncy.21777","article-title":"Young investigator challenge: The morphologic analysis of noninvasive follicular thyroid neoplasm with papillary-like nuclear features on liquid-based cytology: Some insights into their identification","volume":"124","author":"Bizzarro","year":"2016","journal-title":"Cancer Cytopathol"},{"key":"10.25259\/Cytojournal_34_2023\/ref-18","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1002\/cncy.21631","article-title":"Impact of reclassifying noninvasive follicular variant of papillary thyroid carcinoma on the risk of malignancy in the Bethesda System for Reporting Thyroid Cytopathology","volume":"24","author":"Faquin","year":"2016","journal-title":"Cancer Cytopathol"},{"key":"10.25259\/Cytojournal_34_2023\/ref-19","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1097\/01.pai.0000213122.66096.f0","article-title":"Cell membrane reactivity of MIB-1 antibody to Ki67 in human tumors: Fact or artifact?","volume":"15","author":"Leonardo","year":"2007","journal-title":"Appl Immunohistochem Mol Morphol"},{"key":"10.25259\/Cytojournal_34_2023\/ref-20","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1089\/thy.2018.0791","article-title":"GLIS rearrangement is a genomic hallmark of hyalinizing trabecular tumor of the thyroid gland","volume":"29","author":"Nikiforova","year":"2019","journal-title":"Thyroid"},{"key":"10.25259\/Cytojournal_34_2023\/ref-21","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1111\/j.1365-2559.2010.03526.x","article-title":"Hyalinizing trabecular tumour of the thyroid-differential expression of distinct miRNAs compared with papillary thyroid carcinoma","volume":"56","author":"Sheu","year":"2010","journal-title":"Histopathology"},{"key":"10.25259\/Cytojournal_34_2023\/ref-22","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1097\/00000478-200304000-00009","article-title":"Galectin-3 expression in hyalinizing trabecular tumors of the thyroid gland","volume":"27","author":"Gaffney","year":"2003","journal-title":"Am J Surg Pathol"},{"key":"10.25259\/Cytojournal_34_2023\/ref-23","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1111\/pin.12638","article-title":"Stromal tiny black dots, like \u201csugarcoated\u201d, of von Kossa stain is a diagnostic clue to hyalinizing trabecular tumor of the thyroid gland","volume":"68","author":"Hino","year":"2018","journal-title":"Pathol Int"},{"key":"10.25259\/Cytojournal_34_2023\/ref-24","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1111\/his.12123","article-title":"HBME-1 expression in hyalinizing trabecular tumours of the thyroid gland","volume":"62","author":"Lenggenhager","year":"2013","journal-title":"Histopathology"},{"key":"10.25259\/Cytojournal_34_2023\/ref-25","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1159\/000331286","article-title":"Amyloid in cytologic specimens. Differential diagnosis and diagnostic pitfalls","volume":"43","author":"Michael","year":"1999","journal-title":"Acta Cytol"}],"container-title":["Cytojournal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cytojournal.com\/diagnostic-clues-for-hyalinizing-trabecular-tumor-on-fine-needle-aspiration-cytology\/","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cytojournal.com\/diagnostic-clues-for-hyalinizing-trabecular-tumor-on-fine-needle-aspiration-cytology\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T18:13:33Z","timestamp":1734545613000},"score":1,"resource":{"primary":{"URL":"https:\/\/cytojournal.com\/diagnostic-clues-for-hyalinizing-trabecular-tumor-on-fine-needle-aspiration-cytology\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,29]]},"references-count":25,"alternative-id":["10.25259\/Cytojournal_34_2023"],"URL":"https:\/\/doi.org\/10.25259\/cytojournal_34_2023","relation":{},"ISSN":["1742-6413","0974-5963"],"issn-type":[{"value":"1742-6413","type":"electronic"},{"value":"0974-5963","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8,29]]},"article-number":"19"}}