{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T00:09:21Z","timestamp":1788566961002,"version":"build-2803163510"},"reference-count":20,"publisher":"Scientific Scholar","content-domain":{"domain":["cytojournal.com"],"crossmark-restriction":true},"short-container-title":["Cytojournal"],"abstract":"<jats:sec id=\"st1\">\n<jats:title>Objectives:<\/jats:title>\n<jats:p>Recent research shows that most high grade ovarian cancer (OC) originates from the fallopian tube (FT). Cytologic evaluation of FT cells may enable early detection of OC.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st2\">\n<jats:title>Material and Methods:<\/jats:title>\n<jats:p>This was a prospective study with patients enrolled from 3 centers (October 2016\u2013 August 2017). Forty-two women undergoing salpingo-oophorectomy for a pelvic mass suspicious for malignancy or undergoing risk-reducing surgery for <jats:italic>BRCA<\/jats:italic> mutations were included in the study. At the time of scheduled surgery, a novel catheter was used to collect FT cells through hysteroscopy. A pathologist blinded to surgical or pathologic findings evaluated FT cytology, and results were compared to pathology.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st3\">\n<jats:title>Results:<\/jats:title>\n<jats:p>Of the 61 samples collected, 72% (44\/61) met the adequacy criteria (\u22655 clusters of cells with 20 cells in each cluster). Cytology classification criteria were established and applied to adequate samples. Forty-four samples were benign with mixed population of cells with round, oval, and spindled nuclei; 2-dimensional clusters; columnar cell configuration; flat sheets; cilia presence; no\/mild nuclear pleomorphism; no nuclear membrane irregularities; and no nucleoli. Five samples had benign features with reactive nuclear and cytoplasmic changes and\/or background inflammation, which were categorized as \u201creactive atypia.\u201d Two malignant samples had features of 3-dimensional (3D) clusters, loss of mixed population of cells; increased nuclear\/cytoplasmic ratio; nuclear membrane irregularity and nucleoli presence. Three samples with some but not all of malignant features were categorized as \u201cneoplastic\u201d (anisonucleosis; small nucleoli and features suggestive of 3D clusters). Malignant\/ neoplastic samples were labeled as \u201cPositive\u201d (<jats:italic>n<\/jats:italic> = 5) while benign\/reactive samples were labeled as \u201cNegative\u201d (<jats:italic>n<\/jats:italic> = 39). A high concordance rate (95%, 42\/44) was observed between cytology results and histology.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st4\">\n<jats:title>Conclusions:<\/jats:title>\n<jats:p>We characterized cytologic features for pathologically distinct FT samples collected <jats:italic>in vivo<\/jats:italic> using a novel catheter and demonstrated its value in detecting OC.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/cytojournal_7_2020","type":"journal-article","created":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T06:05:40Z","timestamp":1597039540000},"page":"19","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Cytologic studies of <i>in vivo<\/i> fallopian tube specimens in patients undergoing salpingo-oophorectomy"],"prefix":"10.25259","volume":"17","author":[{"given":"Sharmila","family":"Pramanik","sequence":"first","affiliation":[{"name":"Department of Pathology, Santa Clara Valley Medical Center, San Jose, California,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Stanford University School of Medicine, Stanford, California,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Santa Clara Valley Medical Center, San Jose, California,"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2020,8,10]]},"reference":[{"key":"10.25259\/CytoJournal_7_2020\/ref-1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21551","article-title":"Cancer statistics, 2019","volume":"69","author":"Siegel","year":"2019","journal-title":"CA Cancer J Clin"},{"key":"10.25259\/CytoJournal_7_2020\/ref-2","article-title":"SEER Cancer Statistics Review (CSR) 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