{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T11:14:05Z","timestamp":1694690045516},"reference-count":26,"publisher":"Scientific Scholar","content-domain":{"domain":["gjcsro.com"],"crossmark-restriction":true},"short-container-title":["GJCSRO"],"abstract":"\nObjectives:<\/jats:title>\nThe objectives of this study were to assess relationships between vision-related quality of life (QoL) and visual acuity (VA) in Ebola virus disease (EVD) survivors after cataract surgery in the Ebola Viral Persistence in Ocular Tissues and Fluids (EVICT) Study.<\/jats:p>\n<\/jats:sec>\n\nMaterials and Methods:<\/jats:title>\nEVD survivors with undetectable Ebola virus (EBOV) ribonucleic acid in their aqueous humour were eligible to receive manual small-incision cataract surgery (MSICS). Among those that received surgery, assessments of VA and vision-related QoL were assessed pre-and post-cataract surgery. VA was converted from units on a tumbling \u2018E\u2019 chart to the logarithm of the minimal angle of resolution VA (logMAR VA). Vision-related QoL was assessed using the 25-item National Eye Institute Visual Function Questionnaire (NEI VFQ-25). Linear regression was used to evaluate the associations between VA and vision-related QoL. P<\/jats:italic> = 0.05 was considered statistically significant for all analyses.<\/jats:p>\n<\/jats:sec>\n\nResults:<\/jats:title>\nThirty-four EVD survivors underwent cataract surgery in the EVICT study. Before MSICS, the mean logMAR VA was 2.24 (standard deviation [SD]: 0.98), and the mean NEI-VFQ-25 composite score was 54 (SD: 15); however, there was no significant association between the pre-surgery measurements (average difference in VA\/10 unit increase in NEI-VFQ-25: \u22120.04, 95% confidence interval (CI): \u22120.33\u20130.26, P<\/jats:italic> = 0.80). There was a significant improvement in logMAR VA after MSICS (mean: 1.6, P<\/jats:italic> < 0.001), but there was no significant change in the NEI-VFQ-25 composite (\u22120.87, 95% (CI): \u221210.32\u20138.59, P<\/jats:italic> = 0.85). None of the subscales showed significant improvements (P<\/jats:italic> > 0.12 for all); however, the magnitude of the mean change for distance activities (6.65), near activities (6.76), general vision (\u22127.69), social functioning (\u22129.13) and colour vision (13.33) met the criteria for a clinically meaningful difference (4\u20136). In the subset with paired measurements (n<\/jats:italic> = 16), there were no significant association changes in logMAR VA and NEI VFQ-25 composite scores (P<\/jats:italic> > 0.12 for all).<\/jats:p>\n<\/jats:sec>\n\nConclusion:<\/jats:title>\nFollowing cataract surgery, VA in EVD survivors improved, but these improvements were not reflected in NEI VFQ-25 composite scores or specific subscales; however, the small sample size limits generalizability absent more research. Differences in sociocultural context and activities that affect the QoL in resource-limited areas may contribute to the limitations seen with NEI VFQ-25. In addition, better eye dominance could contribute to any lack of association as NEI VFQ-25 evaluates vision as a whole. Further, assessment of factors contributing to improved QoL may help to define the impact of vision health in varied environments.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/gjcsro_29_2022","type":"journal-article","created":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T07:37:59Z","timestamp":1694590679000},"page":"23-29","update-policy":"http:\/\/dx.doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Visual acuity and vision-related quality of life outcomes following cataract surgery in Ebola virus disease survivors"],"prefix":"10.25259","volume":"2","author":[{"given":"Donna","family":"Taraborelli","sequence":"first","affiliation":[{"name":"Harvard T.H. Chan School of Public Health, Harvard University, Cambridge, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanne J.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Medical College of Georgia, Augusta, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tolulope","family":"Fashina","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brent","family":"Hayek","sequence":"additional","affiliation":[{"name":"Department of 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