{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T16:52:10Z","timestamp":1781196730560,"version":"3.54.1"},"reference-count":6,"publisher":"Scientific Scholar","content-domain":{"domain":["ijdvl.com"],"crossmark-restriction":true},"short-container-title":["IJDVL"],"abstract":"\nBackground:<\/jats:title>\nLichen planus (LP) is an idiopathic, chronic, relapsing, inflammatory, autoimmune dermatological disease. The etiopathogenesis of LP is still unclear. Autophagy is a strictly regulated lysosomal degradation pathway that is crucial for maintaining intracellular homeostasis and normal development. The dysregulation of autophagy-associated genes was recognized to increase the susceptibility to multiple diseases, including inflammation, autoimmune disorders and cancer.<\/jats:p>\n<\/jats:sec>\n\nAims:<\/jats:title>\nOur study aimed to detect the expression of autophagy-related gene 9 b (ATG9B) in LP patients compared to normal control persons to investigate the possible role of autophagy in pathogenesis of this disease.<\/jats:p>\n<\/jats:sec>\n\nMethods:<\/jats:title>\nThis case\u2013control study included 30 LP patients and 30 age-, gender-matched healthy controls. Four millimeters punch skin biopsies were obtained from LP lesions and from the controls and they were kept in lysis solution for the stability of the studied parameters and were kept frozen at \u201380\u00b0C till analysis of ATG9B using real-time polymerase chain reaction.<\/jats:p>\n<\/jats:sec>\n\nResults<\/jats:title>\n:<\/jats:italic><\/jats:bold> The level of ATG9B in lesional skin of LP was significantly decreased compared to normal control persons (P<\/jats:italic> < 0.01); also, there was a non-significant relation between ATG9B level and age, sex, duration and family history among LP patients.<\/jats:p>\n<\/jats:sec>\n\nLimitations:<\/jats:title>\nLimited number of patients included in our study (30 patients).<\/jats:p>\n<\/jats:sec>\n\nConclusion:<\/jats:title>\nAutophagy may play a role in the pathogenesis of cutaneous LP.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/ijdvl_1031_18","type":"journal-article","created":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T13:01:59Z","timestamp":1624280519000},"page":"62-64","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The role of autophagy-related gene 9B in lichen planus"],"prefix":"10.25259","volume":"88","author":[{"given":"Rehab Mohamed","family":"Naguib","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abd-El Aziz","family":"El-Rifaie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayat Mohammed","family":"Abd El Wahab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laila Ahmed","family":"Rashed","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Cairo University, Giza, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2021,6,21]]},"reference":[{"key":"10.25259\/IJDVL_1031_18\/ref-1","first-page":"1178","article-title":"Lichen planus in Hunan: 124 patients. Journal of Central South University","volume":"35","author":"Li","year":"2010","journal-title":"Medical science"},{"key":"10.25259\/IJDVL_1031_18\/ref-2","doi-asserted-by":"publisher","first-page":"1988","DOI":"10.1016\/j.febslet.2013.04.025","article-title":"Biology and trafficking of ATG9 and ATG16L1, two proteins that regulate autophagosome formation","volume":"587","author":"Zavodszky","year":"2013","journal-title":"FEBS Lett"},{"key":"10.25259\/IJDVL_1031_18\/ref-3","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.1096\/fj.11-194175","article-title":"Role of autophagy in immunity and autoimmunity, with a special focus on systemic lupus erythematosus","volume":"26","author":"Pierdominici","year":"2012","journal-title":"FASEB J"},{"key":"10.25259\/IJDVL_1031_18\/ref-4","doi-asserted-by":"publisher","first-page":"e12591","DOI":"10.1111\/dth.12591","article-title":"Bacillus CalmetteGuerin, polysaccharide nucleic acid in the treatment of cutaneous and oral lichen planus","volume":"31","author":"Nasr","year":"2018","journal-title":"Dermatol Ther"},{"key":"10.25259\/IJDVL_1031_18\/ref-5","first-page":"889","volume-title":"Rook Textbook of Dermatology","volume":"2","author":"Breathnack","year":"2010","edition":"8th ed"},{"key":"10.25259\/IJDVL_1031_18\/ref-6","doi-asserted-by":"publisher","first-page":"88","DOI":"10.3389\/fimmu.2013.00088","article-title":"Autophagy and autoimmunity crosstalks","volume":"4","author":"Bhattacharya","year":"2013","journal-title":"Front Immunol"}],"container-title":["Indian Journal of Dermatology, Venereology and Leprology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ijdvl.com\/the-role-of-autophagy-related-gene-9b-in-lichen-planus\/","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ijdvl.com\/the-role-of-autophagy-related-gene-9b-in-lichen-planus\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T11:57:46Z","timestamp":1679313466000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ijdvl.com\/the-role-of-autophagy-related-gene-9b-in-lichen-planus\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,21]]},"references-count":6,"alternative-id":["10.25259\/IJDVL_1031_18"],"URL":"https:\/\/doi.org\/10.25259\/ijdvl_1031_18","relation":{},"ISSN":["0973-3922","0378-6323"],"issn-type":[{"value":"0973-3922","type":"electronic"},{"value":"0378-6323","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6,21]]},"article-number":"62"}}