{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T01:55:10Z","timestamp":1773280510209,"version":"3.50.1"},"reference-count":25,"publisher":"Scientific Scholar","content-domain":{"domain":["ijdvl.com"],"crossmark-restriction":true},"short-container-title":["IJDVL"],"abstract":"<jats:sec id=\"st1\">\n<jats:title>Background<\/jats:title>\n<jats:p>Sturge\u2013Weber syndrome (SWS) is a rare condition associated with a GNAQ gene mutation, which affects neural crest cells. A pulsed dye laser (PDL) is a first-line therapy for SWS, but its outcomes are worse than those in patients with port-wine stains (PWS). Photodynamic therapy (PDT) is a promising therapeutic option for PWS. However, its use for PWS associated with SWS has rarely been studied.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st2\">\n<jats:title>Aims<\/jats:title>\n<jats:p>To investigate the therapeutic and adverse effects of photodynamic therapy in treating SWS\u2013associated PWS.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st3\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Patients with SWS and matched patients with large size facial PWS were included in this study. Both colorimetric assessment and visual evaluation were conducted to evaluate patients\u2019 responses to treatment.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st4\">\n<jats:title>Results<\/jats:title>\n<jats:p>Colorimetric assessment (blanching rate) and visual evaluation (scores of colour improvement) showed that after two PDT treatments, the SWS and PWS groups had similar treatment responses (21.2% vs. 29.8%; 3.39 vs. 3.65; <jats:italic>P <\/jats:italic>= 0.18, <jats:italic>P<\/jats:italic> = 0.37). However, there was a significant difference in efficacy between patients with SWS with and without a treatment history (12.4 and 34.9%, respectively; <jats:italic>P<\/jats:italic> = 0.02), as well as between patients with lesions located on the central and lateral faces (18.5 and 36.8%, respectively; <jats:italic>P<\/jats:italic> = 0.01). Both the SWS and PWS groups experienced minor adverse effects, and the frequency of these effects was not significantly different between the two groups.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st5\">\n<jats:title>Limitation<\/jats:title>\n<jats:p>The study was limited by a small sample size and the possibility of later onset of glaucoma. In addition, false-negative magnetic resonance imaging screening results for SWS could not be ruled out due to the young age of some participants.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st6\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Photodynamic therapy is a safe and effective therapeutic option for SWS\u2013associated PWS. Patients without a treatment history, and lesions on the lateral face, responded well, demonstrating good efficacy.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/ijdvl_1075_2022","type":"journal-article","created":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T05:01:11Z","timestamp":1683522071000},"page":"202-209","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Efficacy of hemoporfin-mediated photodynamic therapy in treating Sturge\u2013Weber syndrome associated port-wine stains: A retrospective study"],"prefix":"10.25259","volume":"90","author":[{"given":"Yuanbo","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and 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