{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T18:49:18Z","timestamp":1764874158453,"version":"3.28.0"},"reference-count":11,"publisher":"Scientific Scholar","content-domain":{"domain":["ijdvl.com"],"crossmark-restriction":true},"short-container-title":["Indian J Dermatol Venereol Leprol"],"abstract":"<jats:sec>\n<jats:title>Background<\/jats:title>\n<jats:p>Psoriasis is a chronic, inflammatory, systemic disease with predominant manifestations in the skin and joints impairing patient\u2019s quality of life. A proportion of patients have frequent severe disease exacerbations requiring repeated systemic treatments. There is a scarcity of literature evaluating the role of systemic maintenance therapy in psoriasis patients in preventing such frequent disease flares.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective<\/jats:title>\n<jats:p>To evaluate the efficacy and safety of weekend cyclosporine treatment (WCT) as maintenance therapy in moderate to severe chronic plaque psoriasis patients for the prevention of frequent disease exacerbations.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>In this retrospective cohort study, 22 psoriasis patients with a history of frequent disease exacerbations (\u2265 3 in the last 1 year) who were administered WCT (group A) were compared with the same number of matched patients (age and gender) not on WCT or any systemic maintenance therapy (group B).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Four patients (18.2%) in group A had disease exacerbations which was significantly lower (p = 0.00, Fisher\u2019s exact test) as compared to 21 patients (95.5%) in group B during the study period. Also, patients in group A had significantly lower number of overall exacerbations [mean \u00b1 SD: 0.23 \u00b1 0.53 vs 2.95 \u00b1 1.43) p = 0.00, Mann\u2013Whitney U test] as compared to group B. Four (9.1%) patients in group A encountered adverse effects (acneiform eruptions \u2013 two, mild gingival hyperplasia \u2013 one, myalgia \u2013 one) as compared to three (acneiform eruptions \u2013 two, headache \u2013 one) in group B (p = 1.00).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>WCT significantly reduced the number of disease exacerbations and is a safe and effective mode of maintenance therapy in such subset of psoriasis patients.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/ijdvl_1089_2023","type":"journal-article","created":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T09:30:57Z","timestamp":1716802257000},"page":"707-712","update-policy":"http:\/\/dx.doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy and safety of weekend cyclosporine treatment as maintenance therapy for preventing frequent disease exacerbations in moderate to severe chronic plaque psoriasis patients \u2013 A retrospective cohort study"],"prefix":"10.25259","volume":"90","author":[{"given":"Sunil","family":"Dogra","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheetanshu","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tarun","family":"Narang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitaishi","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinod","family":"Hanumanthu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjeev","family":"Handa","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2024,5,25]]},"reference":[{"key":"10.25259\/IJDVL_1089_2023\/ref-1","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1016\/s0190-9622(98)70325-1","article-title":"Cyclosporine consensus conference: With emphasis on the treatment of 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