{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T16:24:07Z","timestamp":1792859047116,"version":"4.5.0"},"reference-count":15,"publisher":"Scientific Scholar","content-domain":{"domain":["ijdvl.com"],"crossmark-restriction":true},"short-container-title":["IJDVL"],"abstract":"<jats:sec id=\"st1\">\n<jats:title>Background<\/jats:title>\n<jats:p>There are various topical and systemic treatment options for the management of lichen planus. However, it is often difficult to achieve long-term disease control and many of the common therapies may be associated with unwanted side effects.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st2\">\n<jats:title>Aims<\/jats:title>\n<jats:p>To evaluate the effectiveness of 8 mg oral methylprednisolone administered daily in lichen planus by the analysis of medical records.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st3\">\n<jats:title>Methods<\/jats:title>\n<jats:p>In this retrospective cohort study, we compared the rates of improvement between two groups of patients. The first group received 8 mg oral methylprednisolone daily for at least one month. In the second group, patients with similar parameters to the first group (age, sex, disease manifestation) but without systemic glucocorticoid therapy were included. Fisher\u2019s exact test was used to compare the rates of remission in the two groups.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st4\">\n<jats:title>Results<\/jats:title>\n<jats:p>In the daily oral methylprednisolone (<jats:italic>n<\/jats:italic> = 24) and no systemic corticosteroids (<jats:italic>n<\/jats:italic> = 16) groups, 23 (95.8%) and 6 (37.5%) patients achieved partial or complete remission, respectively. The frequency of improvement was significantly higher in patients who received oral methylprednisolone (<jats:italic>P<\/jats:italic> &lt; 0.0001).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st5\">\n<jats:title>Limitations<\/jats:title>\n<jats:p>Limitations of this study include its retrospective design and the relatively small sample size.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st6\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Low dose oral glucocorticoid therapy may be an effective option for the systemic treatment of lichen planus. Based on our results and previous studies, instead of higher doses, longer therapy duration with low doses should be considered.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/ijdvl_1111_2021","type":"journal-article","created":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T10:16:23Z","timestamp":1667902583000},"page":"568-571","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Low dose oral glucocorticoid therapy in lichen planus: A retrospective cohort study"],"prefix":"10.25259","volume":"89","author":[{"given":"Kamilla","family":"Koszor\u00fa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anik\u00f3","family":"Kov\u00e1cs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kende","family":"L\u0151rincz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rta","family":"Medvecz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikl\u00f3s","family":"S\u00e1rdy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2022,10,31]]},"reference":[{"key":"10.25259\/IJDVL_1111_2021\/ref-1","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.4049\/jimmunol.137.8.2485","article-title":"Cloned auto-Ia-reactive T cells elicit lichen planus-like lesion in the skin of syngeneic mice","volume":"137","author":"Saito","year":"1986","journal-title":"J Immunol"},{"key":"10.25259\/IJDVL_1111_2021\/ref-2","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1111\/ddg.14565","article-title":"Lichen planus - a clinical guide","volume":"19","author":"Solimani","year":"2021","journal-title":"J Dtsch Dermatol Ges"},{"key":"10.25259\/IJDVL_1111_2021\/ref-3","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1007\/s00105-017-4115-0","article-title":"Lichen ruber planus: Besser verstehen, besser behandeln! 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