{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T04:43:36Z","timestamp":1698554616955},"reference-count":19,"publisher":"Scientific Scholar","content-domain":{"domain":["ijdvl.com"],"crossmark-restriction":true},"short-container-title":["IJDVL"],"abstract":"<jats:sec id=\"st1\">\n<jats:title>Background<\/jats:title>\n<jats:p>Psoriasis is a multifactorial, hyperproliferative, chronic inflammatory skin disease affecting males and females equally.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st2\">\n<jats:title>Aims<\/jats:title>\n<jats:p>To study the expression of certain non-coding RNAs, Interferon Alpha Inducible Protein 6 (IFI6), previously named Glucose-dependent Insulinotropic Polypeptide 3 (G1P-3), and nucleolar phosphoprotein (in serum and tissue), and to attempt to elucidate their role in the pathogenesis of psoriasis, which in turn might help in treatment.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st3\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Twenty patients with psoriasis and 20 healthy subjects were included in this study. Serum and skin biopsies were obtained from all participants. Molecular biology techniques were employed to estimate the expression levels of long noncoding G1P-3 and nucleolar phosphoprotein in serum and skin biopsy.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st4\">\n<jats:title>Results<\/jats:title>\n<jats:p>Psoriasis patients had a mean age of 41.85 \u00b1 12.29. The median serum G1P-3 level of the patients\u2019 group (3.330) was significantly higher than that of the control group (1.085) (<jats:italic>P<\/jats:italic> \u2264 0.001). Tissue G1P-3 level of the patients\u2019 group (6.495) was also significantly higher compared to that of controls (1.040) (<jats:italic>P<\/jats:italic> \u2264 0.001). Similarly, for nucleolar phosphoprotein, the median serum level of patients\u2019 group (2.030) was significantly higher than that of controls (1.040) (<jats:italic>P<\/jats:italic> \u2264 0.001) and median tissue level (5.425) was also significantly higher than that of controls (1.040) (<jats:italic>P<\/jats:italic> \u2264 0.001).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st5\">\n<jats:title>Limitations<\/jats:title>\n<jats:p>In this study, only outpatients were included and follow-up was not well-handled. For future work, follow-up can be considered.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st6\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Long non-coding G1P-3 as well as nucleolar phosphoprotein may be considered as genetic markers for psoriasis susceptibility. In future, these might provide a novel direction for advances in psoriasis treatment.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/ijdvl_1215_2021","type":"journal-article","created":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T09:47:30Z","timestamp":1674812850000},"page":"828-833","update-policy":"http:\/\/dx.doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The role of glucose-dependent insulinotropic polypeptide 3 (G1P-3) and nucleolar phosphoprotein-1 (NPM1) in pathogenesis of psoriasis"],"prefix":"10.25259","volume":"89","author":[{"given":"Mohamed","family":"Hassan M","sequence":"first","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine, Fayoum University, Faiyum, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samar","family":"ElTahlawi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine, Cairo University, Cairo, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olfat G.","family":"Shaker","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Cairo University, Cairo, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mai","family":"Magdy","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine, Fayoum University, Faiyum, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2023,1,25]]},"reference":[{"key":"10.25259\/IJDVL_1215_2021\/ref-1","doi-asserted-by":"publisher","DOI":"10.1177\/2058738420933742","article-title":"Upregulation of the miRNA-155, miRNA-210, and miRNA-20b in psoriasis patients and their relation to IL-17","volume":"34","author":"El-Komy","year":"2020","journal-title":"Int J Immunopathol Pharmacol"},{"key":"10.25259\/IJDVL_1215_2021\/ref-2","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1111\/j.1468-3083.2008.03064.x","article-title":"Serum and tissue expression of transforming growth factor beta 1 in psoriasis","volume":"23","author":"Zaher","year":"2009","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.25259\/IJDVL_1215_2021\/ref-3","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1177\/0394632016662475","article-title":"Expression of sirtuins 1, 6, tumor necrosis factor, and interferon-\u03b3 in psoriatic patients","volume":"29","author":"Rasheed","year":"2016","journal-title":"Int J Immunopathol Pharmacol"},{"key":"10.25259\/IJDVL_1215_2021\/ref-4","doi-asserted-by":"publisher","first-page":"6925","DOI":"10.1111\/jcmm.16703","article-title":"Transcriptome wide analysis of long non-coding RNA-associated ceRNA regulatory circuits in psoriasis","volume":"25","author":"Lin","year":"2021","journal-title":"J Cell Mol Med"},{"key":"10.25259\/IJDVL_1215_2021\/ref-5","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1111\/j.1600-0625.2010.01066.x","article-title":"The anti-apoptotic protein G1P3 is overexpressed in psoriasis and regulated by the non-coding RNA, PRINS","volume":"19","author":"Szegedi","year":"2010","journal-title":"Exp Dermatol"},{"key":"10.25259\/IJDVL_1215_2021\/ref-6","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1007\/s00424-016-1803-z","article-title":"PRINS, a primate-specific long non-coding RNA, plays a role in the keratinocyte stress response and psoriasis pathogenesis","volume":"468","author":"Szell","year":"2016","journal-title":"Pflugers Arch"},{"key":"10.25259\/IJDVL_1215_2021\/ref-7","doi-asserted-by":"publisher","first-page":"205","DOI":"10.3390\/ijms14010205","article-title":"Expression and functional studies on the noncoding RNA, PRINS","volume":"14","author":"Szegedi","year":"2012","journal-title":"Int J Mol Sci"},{"key":"10.25259\/IJDVL_1215_2021\/ref-8","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1097\/CM9.0000000000001243","article-title":"An update on the role of long non-coding RNAs in psoriasis","volume":"134","author":"Song","year":"2020","journal-title":"Chin Med J (Engl)"},{"key":"10.25259\/IJDVL_1215_2021\/ref-9","doi-asserted-by":"publisher","first-page":"e446","DOI":"10.1038\/emm.2017.272","article-title":"Nucleolar phosphoprotein modulates the alleviation of atopic dermatitis caused by the marine-derived compound dihydroaustrasulfone alcohol","volume":"50","author":"Hung","year":"2018","journal-title":"Exp Mol Med"},{"key":"10.25259\/IJDVL_1215_2021\/ref-10","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1134\/S0026898419040098","article-title":"[Features of the structure and expression of NPM and NCL Genes in cutaneous melanoma]","volume":"53","author":"Ponkratova","year":"2019","journal-title":"Mol Biol (Mosk)"},{"key":"10.25259\/IJDVL_1215_2021\/ref-11","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1046\/j.1365-2133.1999.02963.x","article-title":"Clinical measures of disease severity and outcome in psoriasis: A critical appraisal of their quality","volume":"141","author":"Ashcroft","year":"1999","journal-title":"Br J Dermatol"},{"key":"10.25259\/IJDVL_1215_2021\/ref-12","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.ncrna.2020.06.002","article-title":"The eminent roles of ncRNAs in the pathogenesis of psoriasis","volume":"5","author":"Ghafouri-Fard","year":"2020","journal-title":"Noncoding RNA Res"},{"key":"10.25259\/IJDVL_1215_2021\/ref-13","doi-asserted-by":"publisher","first-page":"24159","DOI":"10.1074\/jbc.M501704200","article-title":"Identification and characterization of a novel, psoriasis susceptibility-related noncoding RNA gene, PRINS","volume":"280","author":"Sonkoly","year":"2005","journal-title":"J Biol Chem"},{"key":"10.25259\/IJDVL_1215_2021\/ref-14","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1007\/s00403-011-1162-8","article-title":"Comparison of stress-induced PRINS gene expression in normal human keratinocytes and HaCaT cells","volume":"303","author":"Bari","year":"2011","journal-title":"Arch Dermatol Res"},{"key":"10.25259\/IJDVL_1215_2021\/ref-15","doi-asserted-by":"publisher","first-page":"762","DOI":"10.3390\/diagnostics10100762","article-title":"PRINS lncRNA is a new biomarker candidate for HPV infection and prognosis of head and neck squamous cell carcinomas","volume":"10","author":"Kopczy\u0144ska","year":"2020","journal-title":"Diagnostics (Basel)"},{"key":"10.25259\/IJDVL_1215_2021\/ref-16","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1007\/s12022-020-09642-1","article-title":"Long Noncoding RNA Expression in adrenal cortical neoplasms","volume":"31","author":"Shiyanbola","year":"2020","journal-title":"Endocr Pathol"},{"key":"10.25259\/IJDVL_1215_2021\/ref-17","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1007\/s00109-012-0950-8","article-title":"Estrogen stimulates the proliferation of human endometrial cancer cells by stabilizing nucleolar phosphoprotein\/B23 (NPM\/B23)","volume":"91","author":"Chao","year":"2013","journal-title":"J Mol Med (Berl)"},{"key":"10.25259\/IJDVL_1215_2021\/ref-18","doi-asserted-by":"publisher","first-page":"853","DOI":"10.5732\/cjc.011.10362","article-title":"Knockdown of nucleolar phosphoprotein induces S-phase arrest in HepG2 cells","volume":"30","author":"Wang","year":"2011","journal-title":"Chin J Cancer"},{"key":"10.25259\/IJDVL_1215_2021\/ref-19","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1007\/s12013-013-9563-2","article-title":"Antiangiogenic effect of methotrexate and PUVA on psoriasis","volume":"67","author":"Shaker","year":"2013","journal-title":"Cell Biochem Biophys"}],"container-title":["Indian Journal of Dermatology, Venereology and Leprology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ijdvl.com\/the-role-of-glucose-dependent-insulinotropic-polypeptide-3-g1p-3-and-nucleolar-phosphoprotein-1-npm1-in-pathogenesis-of-psoriasis\/","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ijdvl.com\/the-role-of-glucose-dependent-insulinotropic-polypeptide-3-g1p-3-and-nucleolar-phosphoprotein-1-npm1-in-pathogenesis-of-psoriasis\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T05:48:26Z","timestamp":1698472106000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ijdvl.com\/the-role-of-glucose-dependent-insulinotropic-polypeptide-3-g1p-3-and-nucleolar-phosphoprotein-1-npm1-in-pathogenesis-of-psoriasis\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,25]]},"references-count":19,"alternative-id":["10.25259\/IJDVL_1215_2021"],"URL":"https:\/\/doi.org\/10.25259\/ijdvl_1215_2021","relation":{},"ISSN":["0973-3922","0378-6323"],"issn-type":[{"value":"0973-3922","type":"electronic"},{"value":"0378-6323","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1,25]]},"article-number":"828"}}