{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T21:17:53Z","timestamp":1783459073315,"version":"3.55.0"},"reference-count":25,"publisher":"Scientific Scholar","content-domain":{"domain":["ijdvl.com"],"crossmark-restriction":true},"short-container-title":["Indian J Dermatol Venereol Leprol"],"abstract":"<jats:sec>\n<jats:title>Background<\/jats:title>\n<jats:p>Pityriasis rubra pilaris (PRP) is a rare papulosquamous disease with a characteristic clinical appearance, including follicular salmon-coloured papules, which can sometimes progress into erythroderma. Both clinical and histopathological findings are important in diagnosing the disease and should be evaluated together.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objectives<\/jats:title>\n<jats:p>There are no guidelines for diagnosis and treatment of the disease. The aim of the present study was to contribute to the clinical diagnosis and treatment approach of this rare disease, which could serve as a clinical guide for dermatologists.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>A total of 70 patients diagnosed with PRP in the last 20 years were included in this retrospective study. Clinical, demographic, and histopathologic profiles; and treatment strategies were analysed. Patients were divided into two groups with \u2018definite\u2019 or \u2018probable\u2019 diagnoses; those diagnosed to have PRP based on both clinical and histopathological findings were classified as having a \u2018definite\u2019 diagnosis; and those with histopathologically non-specific features but clinical findings compatible with PRP were classified as having a \u2018probable\u2019 diagnosis.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Forty (57.1%) patients were females and 30 (42.9%) were males. Their age ranged from 8 to 79 years (mean age 39.57\u00b118.80 years). The median duration of the disease (before patients received the diagnosis) was 7 months (IQR=24). According to biopsy reports, the most common epidermal changes were hyperkeratosis (78.6%) and focal parakeratosis (75.7%), while the \u2018checkerboard pattern,\u2019 which is considered specific for the disease, was detected in only 16 (22.9%) cases. Only 8 biopsy samples (11.4%) had an eosinophilic infiltrate. While 47 (67.1%) patients were classified under \u2018definite diagnosis and 23 (32.9%) were classified under \u2018probable diagnosis.\u2019 The disease duration was longer in patients with definite diagnosis than in patients with probable diagnosis (p=0.045). A total of 33 (47.14%) patients needed systemic therapy in addition to topical treatment. While 4 of these 33 patients were classified as Type 3, the remaining patients were classified as Type 1, classical adult type. Only three Type 1 (classical adult PRP) patients had erythroderma. Oral retinoids, especially acitretin, were the most preferred and effective treatment. Five patients showed improvement with methotrexate and two needed biological agents.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Limitation<\/jats:title>\n<jats:p>The present study is retrospective and includes a relatively limited number of patients.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>PRP is still a rare, difficult-to-manage disease. More studies are required to standardise and improve the diagnosis and treatment approaches for the disease.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/ijdvl_1607_2024","type":"journal-article","created":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T05:04:39Z","timestamp":1741064679000},"page":"S95-S101","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinicopathological and management outcome in 70 patients with pityriasis rubra pilaris: A retrospective analysis"],"prefix":"10.25259","volume":"91","author":[{"given":"Nermin","family":"Karaosmanoglu","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology, Health Sciences University, Ankara Training and Research Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u0131nar Ozdemir","family":"Cetinkaya","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, \u015ei\u015fli Hamidiye Etfal Training and Research Hospital, \u0130stanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130smail","family":"Y\u00fcksel","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Health Sciences University, Ankara Training and Research Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2025,3,4]]},"reference":[{"key":"10.25259\/IJDVL_1607_2024\/ref-1","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1111\/j.1365-4632.2012.05811.x","article-title":"Pityriasis rubra pilaris: Clinicopathological study of 32 cases from Lebanon","volume":"53","author":"Marrouche","year":"2014","journal-title":"Int J Dermatol"},{"key":"10.25259\/IJDVL_1607_2024\/ref-2","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1016\/j.ad.2024.02.019","article-title":"Pityriasis rubra pilaris: A multicentric case series of 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