{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T13:05:49Z","timestamp":1767359149184,"version":"3.48.0"},"reference-count":27,"publisher":"Scientific Scholar","content-domain":{"domain":["ijdvl.com"],"crossmark-restriction":true},"short-container-title":["Indian J Dermatol Venereol Leprol"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cutaneous and systemic plasmacytosis is a rare disorder predominantly observed in individuals of Asian descent. The aetiology, treatment modalities, and prognosis of this condition remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To describe the clinicohistopathologic features and outcomes in patients with cutaneous and systemic plasmacytosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analysed data from 21 patients treated at West China Hospital of Sichuan university from 2011 to 2022.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All patients exhibited characteristic reddish-brown patches or plaques, primarily located on the trunk, head, face, and neck, with one patient also showing affected soles. Lymphadenopathy was present in 38.9% (7\/18), and bone marrow involvement in 100% (7\/7). Polyclonal immunoglobulinemia appeared in 91.67% (11\/12), with elevated IgG4 in 87.5% (7\/8) and IL-6 in 83.3% (5\/6). Monoclonal gene rearrangements were observed in 54.5% (6\/11) of patients. Over 5.3 years, 11.1% (2\/18) partially remitted, while 44.4% (8\/18) progressed, with four developing multicentric Castleman disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Limitations<\/jats:title>\n                    <jats:p>This is a retrospective evaluation with a small number of cases; further prospective studies are warranted to support our inferences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Cutaneous and systemic plasmacytosis often follows a chronic, progressive course. Our findings indicate an overlap in pathological features with cutaneous marginal zone B-cell lymphoma (MZBCL) and an association with IgG4-related disease. Additionally, some cases developed into multicentric Castleman disease. Currently, no effective treatment regimen has been established for this condition.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.25259\/ijdvl_262_2025","type":"journal-article","created":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:05:21Z","timestamp":1760162721000},"page":"82-90","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinicohistopathological features and outcome of cutaneous and systemic plasmacytosis in 21 Chinese cases: A retrospective study"],"prefix":"10.25259","volume":"92","author":[{"given":"Chunyan","family":"Mao","sequence":"first","affiliation":[{"name":"Department of Dermatology, West China School of Medicine\/West China Hospital of Sichuan University, Sichuan University, Chengdu, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenxi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medical Cosmetology, Chongqing Red Cross Hospital (Jiangbei District People\u2019s Hospital), Jiangbei District, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, West China School of Medicine\/West China Hospital of Sichuan University, Sichuan University, Chengdu, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, West China School of Medicine\/West China Hospital of Sichuan University, Sichuan University, Chengdu, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2025,10,9]]},"reference":[{"key":"10.25259\/IJDVL_262_2025\/ref-1","doi-asserted-by":"publisher","first-page":"1314","DOI":"10.1001\/archderm.122.11.1314","article-title":"Systemic 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