{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T22:34:45Z","timestamp":1788388485433,"version":"build-2803163510"},"reference-count":54,"publisher":"Scientific Scholar","content-domain":{"domain":["ijdvl.com"],"crossmark-restriction":true},"short-container-title":["IJDVL"],"abstract":"\nBackground<\/jats:title>\nKnowledge about cutaneous microbiota in psoriasis vulgaris and seborrheic dermatitis is limited, and a comparison of microbiota in the two diseases was not yet previously undertaken.<\/jats:p>\n<\/jats:sec>\n\nAims\/Objectives<\/jats:title>\nThis study aimed to compare the scalp lesional and non-lesional microbiota in psoriasis vulgaris and seborrheic dermatitis with that in a healthy control group.<\/jats:p>\n<\/jats:sec>\n\nMethods<\/jats:title>\nFifty samples were taken with sterile swabs from patients\u2019 and controls\u2019 scalps, and 16S rRNA gene sequencing analyses were performed.<\/jats:p>\n<\/jats:sec>\n\nResults<\/jats:title>\nAlpha and beta diversity analyses showed that bacterial load and diversity were significantly increased in psoriasis vulgaris and seborrheic dermatitis lesions compared to the controls. As phyla, Actinobacteria<\/jats:italic> decreased and Firmicutes<\/jats:italic> increased, while as genera, Propionibacterium<\/jats:italic> decreased; Staphylococcus, Streptococcus, Aquabacterium, Neisseria<\/jats:italic> and Azospirillum<\/jats:italic> increased in lesions of both diseases. Specifically, Mycobacterium, Finegoldia, Haemophilus<\/jats:italic> and Ezakiella<\/jats:italic> increased in psoriasis vulgaris and Enhydrobacter, Micromonospora<\/jats:italic> and Leptotrichia<\/jats:italic> increased in seborrheic dermatitis lesions. Mycobacterium, Ezakiella<\/jats:italic> and Peptoniphilus<\/jats:italic> density were higher in psoriasis vulgaris compared to seborrheic dermatitis lesions. The bacterial diversity and load values of non-lesional scalp in psoriasis vulgaris and seborrheic dermatitis lay between those of lesional areas and controls.<\/jats:p>\n<\/jats:sec>\n\nLimitations<\/jats:title>\nThe small sample size is the main limitation of this study.<\/jats:p>\n<\/jats:sec>\n\nConclusion<\/jats:title>\nHigher bacterial diversity was detected in lesions of both psoriasis and seborrheic dermatitis compared to the controls, but similar alterations were observed when the two diseases were compared. Although these differences could be a result rather than a cause of the two diseases, there is a need to analyze all members of the microbiota and microbiota-host interactions.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/ijdvl_323_21","type":"journal-article","created":{"date-parts":[[2022,3,19]],"date-time":"2022-03-19T12:20:52Z","timestamp":1647692452000},"page":"738-748","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Is cutaneous microbiota a player in disease pathogenesis? 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