{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T00:29:58Z","timestamp":1715300998315},"reference-count":14,"publisher":"Scientific Scholar","content-domain":{"domain":["ijdvl.com"],"crossmark-restriction":true},"short-container-title":["IJDVL"],"abstract":"<jats:sec>\n<jats:title>Background<\/jats:title>\n<jats:p>Psoriasis is a common chronic inflammatory disorder affecting all aspects of a patient\u2019s life. Nail involvement is frequent, but little is known about its associated inflammatory biomarker profile, including similarities or differences from cutaneous disease.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Aims<\/jats:title>\n<jats:p>We conducted this cross-sectional study to evaluate serum levels of inflammatory cytokines [tumour necrosis factor-alpha (TNF-\u03b1) and interleukin -17 (IL-17)] in patients with nail psoriasis and compared these to psoriasis patients without nail involvement, as well as in non-psoriatic healthy controls.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>Adult psoriasis patients with (Group I, n = 30) and without nail involvement (Group-II, n = 30) were sequentially recruited. In addition, non-psoriatic healthy controls (Group-III, n = 20) were recruited. The nail disease severity by NAPSI score was determined for patients in Group I. Cutaneous disease severity (by PASI score) and presence of psoriatic arthritis (through CASPAR criteria) were evaluated for patients in Groups I and II. Serum levels of TNF-\u03b1, IL-17, erythrocyte sedimentation rate (ESR), rheumatoid factor (RA factor), and anti-cyclic citrullinated peptide antibody (Anti-CCP) were evaluated for all three groups.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>The median age was significantly higher for Group I as compared to Group II patients (41 \u00b1 12.6 years vs 30 \u00b1 12.4 years, p = 0.017). Group I patients also had higher median PASI score than Group II patients, although the difference was not statistically significant (10 \u00b1 11.41 vs 6.50 \u00b1 5.46, p = 0.275). The mean serum IL-17 levels were significantly higher for Group-I (113.39 \u00b1 251.30 pg\/mL) than Group II (27.91 \u00b1 18.22 pg\/mL, p = 0.002) and Group III (25.67 \u00b1 12.08 pg\/mL, p = 0.005). A weak positive correlation was found between NAPSI and serum IL-17 levels (Spearman\u2019s Rho = 0.355) though not statistically significant (p = 0.054). Correlation between serum IL-17 and PASI was poor for Group-I patients (Spearman\u2019s Rho = 0.13, p = 0.944) and strongly negative for Group-II patients (Spearman\u2019s Rho = \u22120.368, statistically significant with p = 0.045). The mean serum levels of TNF-\u03b1 were below the detection threshold of the assay kit, hence no meaningful comparison could be made.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Limitations<\/jats:title>\n<jats:p>A small sample size and low sensitivity of TNF-\u03b1 assay kit.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Our study showed that nail psoriasis could be independently associated with an elevation of IL-17. This can help choose appropriate drugs and estimate drug response in patients with nail psoriasis. <\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/ijdvl_367_2023","type":"journal-article","created":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T10:51:46Z","timestamp":1715251906000},"page":"1-5","update-policy":"http:\/\/dx.doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Serum levels of tumour necrosis factor (TNF-\u03b1) and interleukin-17 (IL-17) in patients with nail psoriasis: A cross-sectional study"],"prefix":"10.25259","volume":"0","author":[{"given":"Anil Kumar","family":"Bhoi","sequence":"first","affiliation":[{"name":"Department of Dermatology and STD, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chander","family":"Grover","sequence":"additional","affiliation":[{"name":"Department of Dermatology and STD, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Archana","family":"Singal","sequence":"additional","affiliation":[{"name":"Department of Dermatology and STD, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bineeta","family":"Kashyap","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dibyashree","family":"Dibyashree","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2024,5,4]]},"reference":[{"key":"10.25259\/IJDVL_367_2023\/ref-1","doi-asserted-by":"publisher","first-page":"319","DOI":"10.4103\/0019-5154.135470","article-title":"Nail psoriasis: The journey so far","volume":"59","author":"Dogra","year":"2014","journal-title":"Indian J Dermatol"},{"key":"10.25259\/IJDVL_367_2023\/ref-2","doi-asserted-by":"publisher","first-page":"508178","DOI":"10.1155\/2014\/508178","article-title":"Serum levels of TNF- \u03b1 , IL-12\/23 p40, and IL-17 in psoriatic patients with and without nail psoriasis: A cross-sectional study","volume":"2014","author":"Kyriakou","year":"2014","journal-title":"Sci World J"},{"key":"10.25259\/IJDVL_367_2023\/ref-3","doi-asserted-by":"publisher","first-page":"2665","DOI":"10.1002\/art.21972","article-title":"Classification criteria for psoriatic arthritis: Development of new criteria from a large international study","volume":"54","author":"Taylor","year":"2006","journal-title":"Arthritis Rheum"},{"key":"10.25259\/IJDVL_367_2023\/ref-4","doi-asserted-by":"publisher","first-page":"11574","DOI":"10.3390\/ijms222111574","article-title":"Current concepts of psoriasis immunopathogenesis","volume":"22","author":"Vi\u010di\u0107","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.25259\/IJDVL_367_2023\/ref-5","doi-asserted-by":"publisher","first-page":"1196323","DOI":"10.3389\/fmolb.2023.1196323","article-title":"Clinical application of serum biomarkers for detecting and monitoring of chronic plaque psoriasis","volume":"10","author":"Cruz","year":"2023","journal-title":"Front Mol Biosci"},{"key":"10.25259\/IJDVL_367_2023\/ref-6","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1155\/MI.2005.273","article-title":"Serum levels of TNF-alpha, IFN-gamma, IL-6, IL-8, IL-12, IL-17, and IL-18 in patients with active psoriasis and correlation with disease severity","volume":"20","author":"Arican","year":"2005","journal-title":"Mediators Inflamm"},{"key":"10.25259\/IJDVL_367_2023\/ref-7","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1111\/j.1365-2230.2009.03704.x","article-title":"Serum cytokines and growth factor levels in Japanese patients with psoriasis","volume":"35","author":"Takahashi","year":"2010","journal-title":"Clin Exp Dermatol"},{"key":"10.25259\/IJDVL_367_2023\/ref-8","doi-asserted-by":"publisher","first-page":"467541","DOI":"10.1155\/2014\/467541","article-title":"Serum levels of TNF-\u03b1, IL-12\/23p40, and IL-17 in plaque psoriasis and their correlation with disease severity","volume":"2014","author":"Kyriakou","year":"2014","journal-title":"J Immunol Res"},{"key":"10.25259\/IJDVL_367_2023\/ref-9","doi-asserted-by":"publisher","first-page":"40","DOI":"10.5455\/msm.2022.33.40-43","article-title":"Serum levels of tumor necrosis factor - 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