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It is a collagen-related disorder characterized by excessive fibrosis in the oral submucosa, hyalinization and degenerative changes in the muscles. This disease has become a challenging entity for dermatologists due to resemblance of its features to various mucocutaneous conditions. An improper diagnosis can lead to wrong treatment and additional complications. Dermatologists need to be aware of the characteristic features of this disease which can distinguish it from other similar conditions. This review aims to focus on the detailed aspects of oral submucous fibrosis including its historical background, etiological factors, pathogenesis, clinical features, differential diagnosis, investigations, management and future perspectives.<\/jats:p>","DOI":"10.25259\/ijdvl_371_20","type":"journal-article","created":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T10:22:54Z","timestamp":1619173374000},"page":"768-777","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Oral submucous fibrosis: An overview of a challenging entity"],"prefix":"10.25259","volume":"87","author":[{"given":"Sonia","family":"Gupta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manveen Kaur","family":"Jawanda","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology & Forensic Odontology, Luxmibai Institute of Dental Sciences and Hospital, Patiala, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2021,4,23]]},"reference":[{"key":"10.25259\/IJDVL_371_20\/ref-1","doi-asserted-by":"publisher","first-page":"382","DOI":"10.4103\/jomfp.JOMFP_223_18","article-title":"A novel clinical protocol for therapeutic intervention in oral submucous fibrosis: An evidence based approach","volume":"22","author":"More","year":"2018","journal-title":"J Oral Maxillofac Pathol"},{"key":"10.25259\/IJDVL_371_20\/ref-2","doi-asserted-by":"publisher","first-page":"vii","DOI":"10.1111\/j.1523-1747.2003.12651.x","article-title":"A mouthful of epithelial-mesenchymal interactions","volume":"121","author":"Hughes","year":"2003","journal-title":"J Invest Dermatol"},{"key":"10.25259\/IJDVL_371_20\/ref-3","doi-asserted-by":"publisher","first-page":"22","DOI":"10.3390\/ijms20122940","article-title":"Oral Submucous Fibrosis: A Review on Etiopathogenesis, Diagnosis, and Therapy","volume":"20","author":"Shih","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.25259\/IJDVL_371_20\/ref-4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40463-020-0399-7","article-title":"Oral submucous fibrosis: A contemporary narrative review with a proposed interprofessional approach for an early diagnosis and clinical management","volume":"49","author":"Rao","year":"2020","journal-title":"J Otolaryngol Head Neck Surg"},{"key":"10.25259\/IJDVL_371_20\/ref-5","volume-title":"Benign and Malignant tumours of Oral Cavity. 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