{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T22:39:47Z","timestamp":1789684787569,"version":"4.0.1"},"reference-count":12,"publisher":"Scientific Scholar","content-domain":{"domain":["ijdvl.com"],"crossmark-restriction":true},"short-container-title":["IJDVL"],"abstract":"<jats:sec>\n<jats:title>Background<\/jats:title>\n<jats:p>Isolated nail lichen planus (NLP) without mucocutaneous involvement is rare. Literature about the clinical profile and management is scarce. <\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Aims\/Objective<\/jats:title>\n<jats:p>We attempted to characterize the clinico-demographic profile and analyze the management outcome of patients with isolated nail lichen planus.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>Records of 15 patients were evaluated, and their demographic profile, clinical features of the nail matrix and nail bed disease, onychoscopy findings, histopathological features, treatment given, and follow-up progress were analysed.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Data from 15 patients were collected. The mean age of the patients was 28.6 \u00b1 19.0 years (range 3.5 years to 56 years). The gender ratio was 0.8 with 7 males and 8 females. The average disease duration at presentation was 2.8 \u00b1 2.6 years (6 months\u20139 years). The average number of nails involved was 16.4 \u00b1 4.6 (8-20 nails). All 20 nails were involved in 9 (60%) patients. Nail matrix \u00adinvolvement was seen in all, with onychorrhexis being the most common manifestation, which was seen in 11 (73.3%) patients. Nail bed involvement was seen in 11 (73.3%) patients, with onycholysis being the most common presentation. Severe nail disease was seen in 7 (46.7%) patients, and 5 (33.3%) had pterygium involving an average of 3.4 nails. Moderate to good improvement was observed in 9 (60%) patients after an average of 6.1 \u00b1 2.4 (3-9) treatment sessions with intramuscular and intramatricial triamcinolone acetonide injection. Of these, 2\/9 (22.2%) developed disease recurrence in a few nails after an interval of 1 and 1.5 years, respectively. Two patients achieved complete clinical cures that persisted beyond 2 years of follow-up.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Limitations<\/jats:title>\n<jats:p>Retrospective nature of the series and the small sample size are the major limitations.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>The risk of permanent disfigurement is high in NLP and calls for an early diagnosis and prompt treatment. Intralesional and intramuscular steroids are first-line therapeutic options depending upon the number of nails involved.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/ijdvl_449_2023","type":"journal-article","created":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T11:14:42Z","timestamp":1698923682000},"page":"329-335","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Clinical characteristics and management outcomes in isolated nail lichen planus: A retrospective case series"],"prefix":"10.25259","volume":"90","author":[{"given":"Archana","family":"Singal","sequence":"first","affiliation":[{"name":"Department of Dermatology and STD, University College of Medical Sciences, Dwarka, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishal","family":"Gaurav","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, All India Institute of Medical Sciences, Dwarka, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ishmeet","family":"Kaur","sequence":"additional","affiliation":[{"name":"Dermosphere Clinic, Dwarka, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2023,10,26]]},"reference":[{"key":"10.25259\/IJDVL_449_2023\/ref-1","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1016\/0190-9622(93)70100-8","article-title":"Nail lichen planus: Clinical and pathologic study of twenty-four patients","volume":"28","author":"Tosti","year":"1993","journal-title":"J Am Acad Dermatol."},{"key":"10.25259\/IJDVL_449_2023\/ref-2","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1684\/ejd.2010.0952","article-title":"Nail lichen planus: Response to treatment and long-term follow-up","volume":"20","author":"Piraccini","year":"2010","journal-title":"Eur J Dermatol."},{"key":"10.25259\/IJDVL_449_2023\/ref-3","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1111\/j.1468-3083.2011.04288.x","article-title":"Nail lichen planus: Epidemiological, clinical, pathological, therapeutic and prognosis study of 67 cases","volume":"26","author":"Goettmann","year":"2012","journal-title":"J EurAcad Dermatol Venereol."},{"key":"10.25259\/IJDVL_449_2023\/ref-4","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.annder.2014.09.023","article-title":"Caract\u00e9ristiquescliniques et \u00e9volutives du lichen plan ungu\u00e9al\u00a0: \u00e9tude descriptive de 20\u00a0patients [Clinical characteristics of nail lichen planus and follow-up: A descriptive study of 20 patients]","volume":"142","author":"Chiheb","year":"2015","journal-title":"Ann Dermatol Venereol."},{"key":"10.25259\/IJDVL_449_2023\/ref-5","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jdcr.2021.09.015","article-title":"Clinical features and treatment outcomes of nail lichen planus: A retrospective study","volume":"22;17","author":"Wechsuruk","year":"2021","journal-title":"JAAD Case Rep."},{"key":"10.25259\/IJDVL_449_2023\/ref-6","doi-asserted-by":"publisher","first-page":"1717","DOI":"10.1016\/j.jaad.2020.02.056","article-title":"Isolated nail lichen planus: An expert consensus on treatment of the classical form","volume":"83","author":"Iorizzo","year":"2020","journal-title":"J Am Acad Dermatol."},{"key":"10.25259\/IJDVL_449_2023\/ref-7","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1016\/s0190-9622(86)70097-2","article-title":"Longitudinal nail biopsy in evaluation of acquired nail dystrophies","volume":"14","author":"Hanno","year":"1986","journal-title":"J Am Acad Dermatol."},{"key":"10.25259\/IJDVL_449_2023\/ref-8","first-page":"11","article-title":"Histopathological evaluation of nail lichen planus: A cross-sectional study","volume":"48","author":"Kharghoria","year":"2021","journal-title":"J CutanPathol."},{"key":"10.25259\/IJDVL_449_2023\/ref-9","first-page":"1027","article-title":"Nail lichen planus in children: Clinical features, response to treatment, and long-term follow-up","volume":"137","author":"Tosti","year":"2001","journal-title":"Arch Dermatol."},{"key":"10.25259\/IJDVL_449_2023\/ref-10","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1111\/ijd.16167","article-title":"Description of the most severe signs in nail lichen planus: A strategy to contribute to the diagnosis of the severe stage","volume":"61","author":"Ceccarelli","year":"2022","journal-title":"Int J Dermatol."},{"key":"10.25259\/IJDVL_449_2023\/ref-11","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1001\/jamadermatol.2020.4555","article-title":"Tofacitinib as treatment for nail lichen planus associated with alopecia universalis","volume":"157","author":"Iorizzo","year":"2021","journal-title":"JAMA Dermatol."},{"key":"10.25259\/IJDVL_449_2023\/ref-12","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1001\/jamadermatol.2021.5082","article-title":"Treatment of severe nail lichen planus with baricitinib","volume":"158","author":"P\u00fcnchera","year":"2022","journal-title":"JAMA Dermatol."}],"container-title":["Indian Journal of Dermatology, Venereology and 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