{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T11:07:19Z","timestamp":1789556839577,"version":"build-2803163510"},"reference-count":41,"publisher":"Scientific Scholar","content-domain":{"domain":["ijdvl.com"],"crossmark-restriction":true},"short-container-title":["IJDVL"],"abstract":"<jats:sec id=\"st1\">\n<jats:title>Background<\/jats:title>\n<jats:p>Mycetoma is widespread in Yemen; however, there are only a few documented reports on the entity from this geographical area.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st2\">\n<jats:title>Methods<\/jats:title>\n<jats:p>A prospective study of 184 cases of mycetoma (male 145 and female 39) from different regions of north-western Yemen was conducted between July 2000 and May 2014. Clinical profile was recorded in a standardized protocol. The diagnosis was based on clinical features, X-ray studies, examination of grains, and histopathology.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st3\">\n<jats:title>Results<\/jats:title>\n<jats:p>Eumycetoma was diagnosed in 129, caused by <jats:italic>Madurella mycetomatis<\/jats:italic> in 124, <jats:italic>Leptosphaeria senegalensis<\/jats:italic> in one and pale grain fungus in four, whereas actinomycetoma occurred in 55, caused by <jats:italic>Streptomyces somaliensis<\/jats:italic> in 29, <jats:italic>Actinomadura madurai<\/jats:italic> in nine, <jats:italic>Actinomadura pelletieri<\/jats:italic> in one, and <jats:italic>Nocardia<\/jats:italic> in sixteen. Eumycetoma cases were treated with prolonged course of antifungal drugs, mostly ketoconazole, with itraconazole being used in four patients, along with excision or debulking. Results were better when antifungal drugs were given two to three months before surgery and in those who received itraconazole. Actinomycetoma cases were initially treated with co-trimoxazole monotherapy; later streptomycin was added in 30 cases. Six patients who did not show adequate improvement and two others from the start were treated with modified Welsh regimen and with good results.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st4\">\n<jats:title>Limitations<\/jats:title>\n<jats:p>Identification of different causative agents was done by histopathology and could not be reconfirmed by culture.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st5\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Mycetoma is widespread in north-western Yemen with a higher incidence of eumycetoma and a majority of the cases were caused by <jats:italic>Madurella mycetomatis<\/jats:italic>. Modified Welsh regimen in actinomycetoma and itraconazole with excision in eumycetoma showed the best results.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/ijdvl_500_2021","type":"journal-article","created":{"date-parts":[[2022,3,12]],"date-time":"2022-03-12T11:00:31Z","timestamp":1647082831000},"page":"615-622","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Mycetoma in north-western Yemen: Clinico-epidemiological and histopathological study"],"prefix":"10.25259","volume":"88","author":[{"given":"Mishri Lal","family":"Khatri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sultan Ahmed Saif","family":"Al Kubati","sequence":"additional","affiliation":[{"name":"Department of Pathology, Saudi Hospital, Hajjah, Yemen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismail Ahmed","family":"Gaffer","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Saudi Hospital, Hajjah, Yemen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaban M. 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