{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T03:45:46Z","timestamp":1774669546299,"version":"3.50.1"},"reference-count":44,"publisher":"Scientific Scholar","content-domain":{"domain":["ijdvl.com"],"crossmark-restriction":true},"short-container-title":["IJDVL"],"abstract":"\nBackground<\/jats:title>\nMelanoma is an aggressive cutaneous cancer. Acral lentiginous melanoma is a melanoma subtype arising on palms, soles, and nail-units. The incidence, prevalence and prognosis differ among populations. The link between expression of major histocompatibility complex Class II alleles and melanoma progression is known. However, available studies report variable results regarding the association of melanoma with specific HLA Class II loci.<\/jats:p>\n<\/jats:sec>\n\nAims<\/jats:title>\nThe aim of the study was to determine HLA Class II allele frequencies in acral lentiginous melanoma patients and healthy Mexican Mestizo individuals.<\/jats:p>\n<\/jats:sec>\n\nMethods<\/jats:title>\nEighteen patients with acral lentiginous melanoma and 99 healthy controls were recruited. HLA Class II typing was performed based on the sequence-specific oligonucleotide method.<\/jats:p>\n<\/jats:sec>\n\nResults<\/jats:title>\nThree alleles were associated with increased susceptibility to develop acral lentiginous melanoma, namely: HLA-DRB1*13:01; pC = 0.02, odds ratio = 6.1, IC95% = 1.4\u201325.5, HLA-DQA1*01:03; pC = 0.001, odds ratio = 9.3, IC95% = 2.7\u201331.3 and HLA-DQB1*02:02; pC = 0.01, odds ratio = 3.7, IC95% = 1.4\u201310.3.<\/jats:p>\n<\/jats:sec>\n\nLimitations<\/jats:title>\nThe small sample size was a major limitation, although it included all acral lentiginous melanoma patients seen at the dermatology department of Dr. Manuel Gea Gonz\u00e1lez General Hospital during the study period.<\/jats:p>\n<\/jats:sec>\n\nConclusion<\/jats:title>\nHLA-DRB1*13:01, HLA-DQB1*02:02 and HLA-DQA*01:03 alleles are associated with increased susceptibility to develop acral lentiginous melanoma in Mexican Mestizo patients.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/ijdvl_627_19","type":"journal-article","created":{"date-parts":[[2021,12,31]],"date-time":"2021-12-31T12:29:14Z","timestamp":1640953754000},"page":"608-614","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Human leukocyte antigen Class II alleles associated with acral lentiginous melanoma in Mexican Mestizo patients: A case-control study"],"prefix":"10.25259","volume":"88","author":[{"given":"Rodrigo","family":"Roldan-Marin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Rangel-Gamboa","sequence":"additional","affiliation":[{"name":"Ecology of Pathogenic Agents, Division of Research, General Hospital Dr. Manuel Gea Gonz\u00e1lez, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda E.","family":"Vega-Memije","sequence":"additional","affiliation":[{"name":"Department of Dermatology, General Hospital Dr. Manuel Gea Gonz\u00e1lez, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana","family":"Hern\u00e1ndez-Do\u00f1o","sequence":"additional","affiliation":[{"name":"Department of Transplant, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Ruiz-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Fundaci\u00f3n Cl\u00ednica M\u00e9dica Sur A.C, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio","family":"Granados","sequence":"additional","affiliation":[{"name":"Department of Transplant, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, 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