{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:20:37Z","timestamp":1791498037238,"version":"4.3.4"},"reference-count":30,"publisher":"Scientific Scholar","content-domain":{"domain":["ijdvl.com"],"crossmark-restriction":true},"short-container-title":["Indian J Dermatol Venereol Leprol"],"abstract":"<jats:sec>\n<jats:title>Background<\/jats:title>\n<jats:p>Handheld narrowband ultraviolet B (NB-UVB) device is a portable, home-based, patient-friendly equipment used in vitiligo. It is a newer promising treatment that lacks generalised consensus due to heterogenicity among studies.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective<\/jats:title>\n<jats:p>To determine the clinical efficacy and safety profile of handheld NB-UVB devices in the treatment of vitiligo.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>Following the PRISMA guidelines and using appropriate keywords, the Embase, PubMed and Scopus databases were searched on 28 November 2023. Data on the proportion of patients with a percentage of re-pigmentation and toxicity were extracted from the included studies. Random effects and fixed model were utilised to generate pooled estimates via meta-analysis.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Out of 250 articles, 13 studies (557 patients) were included. The extent of repigmentation achieved over a median duration of 6 months (range 3-12 months) was quantified to be &gt; 25%, &gt; 50%, and &gt;75 % in 63.6% (95% CI: 51.0\u201375.3%), 40.8% (95% CI: 30.4\u201351.6%) and 15.4% (95% CI: 7.6\u201325.3%) of patients respectively. After 12 weeks of treatment, the proportions of patients achieving &gt; 25%, &gt; 50%, and &gt;75% re-pigmentation were 31.1% (95% CI: 9.6\u201358.3%), 12.9% (95% CI: 3.1\u201328.1%) and 6.5% (95% CI: 1.7\u201314.1%), respectively. Similarly, at 24 weeks, these proportions were 53.2% (95% CI: 24.5\u201380.7%), 36.7% (95% CI: 15.8\u201360.5%), and 11.1% (95% CI: 2.9\u201323.7%). Minimal erythema dose (MED) calculation-based therapy was not significantly better than therapy given without MED calculation (p = 0.43). The studies with only stable vitiligo patients did not achieve significantly greater &gt; 25% (p = 0.06), &gt; 50% (p = 0.80), and &gt; 75% (p = 0.25) re-pigmentation compared to the studies that also included active or slowly progressive vitiligo. Three sessions per week resulted in significantly higher &gt; 50% (p &lt; 0.01) and &gt; 75% (p = 0.01) re-pigmentation. Totally, 11.3% (38\/334) of patients showed no response to therapy. The most commonly reported adverse event was erythema in 33.4% (95% CI: 19.3\u201349.2%) of patients, with grade 3 and 4 erythema in 27 and 15 patients, respectively. Other adverse events included pruritus, burning, hyperpigmentation, dryness, and blister formation observed in 22.1%, 16.4%, 19.1%, 9.8%, and 9.7% of patients, respectively.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Handheld NB-UVB portable home-based devices are an efficacious and safe treatment option in vitiligo patients even without MED calculation, when the treatment frequency is three to four sessions per week.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/ijdvl_71_2024","type":"journal-article","created":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T09:20:32Z","timestamp":1737019232000},"page":"321-331","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Clinical efficacy and safety profile of handheld narrow band ultraviolet B device therapy in vitiligo \u2013 Systematic review and meta-analysis"],"prefix":"10.25259","volume":"91","author":[{"given":"Sujay","family":"Khandpur","sequence":"first","affiliation":[{"name":"Department of Dermatology, All India Institute of Medical Sciences, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suvesh","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Dermatology, All India Institute of Medical Sciences, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debopriya","family":"Paul","sequence":"additional","affiliation":[{"name":"Department of Dermatology & STD, All India Institute of Medical Sciences, Patna, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2025,1,11]]},"reference":[{"key":"10.25259\/IJDVL_71_2024\/ref-1","doi-asserted-by":"publisher","first-page":"e0163806","DOI":"10.1371\/journal.pone.0163806","article-title":"The prevalence of vitiligo: A 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