{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T16:35:43Z","timestamp":1788280543980,"version":"build-2803163510"},"reference-count":27,"publisher":"Scientific Scholar","content-domain":{"domain":["ijdvl.com"],"crossmark-restriction":true},"short-container-title":["IJDVL"],"abstract":"\n Background and objectives:<\/jats:title>\n Port-wine stains are defined as congenital benign vascular lesions. The treatment of port-wine stains remains a challenge, worldwide. This study aimed to analyze the histological characteristics in different types of port-wine stains and provide guidance for clinical decision-making.<\/jats:p>\n <\/jats:sec>\n \n Methods and materials:<\/jats:title>\n Biopsies were from the hospital from 2015 to 2021. H&E staining, Immunofluorescence staining, Masson\u2019s trichrome staining and Weigert staining were performed on the tissues.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n A total of 35 port-wine stains patients were included in the study of four distinct types, namely red port-wine stains (11 cases), purple port-wine stains (seven cases), hypertrophic port-wine stains (nine cases) and nodular port-wine stains (eight cases). The mean vessel diameter of the different types was 38.7 \u00b1 5.9 \u03bcm, 93.5 \u00b1 9.7 \u03bcm, 155.6 \u00b1 21.8 \u03bcm and 155.6 \u00b1 29.54 \u03bcm, respectively. Mean vessel depth was 396.4 \u00b1 31 \u03bcm, 944.2 \u00b1 105.4 \u03bcm, 2,971 \u00b1 161.3 \u03bcm and 3,594 \u00b1 364.6 \u03bcm, respectively. The vessels in red port-wine stains, purple port-wine stains and hypertrophic port-wine stains were mainly composed of capillary and venous malformations, whereas those in nodular port-wine stains were venous or arteriovenous malformations.<\/jats:p>\n <\/jats:sec>\n \n Limitation:<\/jats:title>\n The main limitation of the current study was the small number of patients.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n As the disease progresses, vessel diameters become larger, the vessel wall becomes thicker and vessels were found in a greater depth. A treatment plan should be scientifically formulated keeping in mind the histological characteristics of port-wine stains.<\/jats:p>\n <\/jats:sec>","DOI":"10.25259\/ijdvl_730_2021","type":"journal-article","created":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T05:52:08Z","timestamp":1652161928000},"page":"204-212","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Histological analysis of different types of port-wine stains to guide clinical decision making: A retrospective study"],"prefix":"10.25259","volume":"89","author":[{"given":"Lian","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Core Facility, West China Hospital, Sichuan University, Wuhou District, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of medical cosmetology, Chengdu Second People\u2019s Hospital, Qingyun South Street, Chengdu, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxue","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erlong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danfeng","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2022,5,31]]},"reference":[{"key":"10.25259\/IJDVL_730_2021\/ref-1","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1111\/jdv.14490","article-title":"Safety and efficacy of dual-wavelength laser (1064 + 595 nm) for treatment of non-treated port-wine stains","volume":"32","author":"Wang","year":"2018","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.25259\/IJDVL_730_2021\/ref-2","doi-asserted-by":"publisher","first-page":"110901","DOI":"10.1117\/1.JBO.17.11.110901","article-title":"Simulating light transport through skin for color prediction of port wine stain lesions: A review","volume":"17","author":"Lister","year":"2012","journal-title":"J Biomed Opt"},{"key":"10.25259\/IJDVL_730_2021\/ref-3","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1046\/j.1365-2133.1998.02351.x","article-title":"Port-wine stains unresponsive to pulsed dye laser: Explanations and solutions","volume":"139","author":"Lanigan","year":"1998","journal-title":"Br J Dermatol"},{"key":"10.25259\/IJDVL_730_2021\/ref-4","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1001\/archotol.1996.01890230022005","article-title":"Port-wine stains. 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