{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T08:12:30Z","timestamp":1778141550534,"version":"3.51.4"},"reference-count":11,"publisher":"Scientific Scholar","content-domain":{"domain":["ijdvl.com"],"crossmark-restriction":true},"short-container-title":["Indian J Dermatol Venereol Leprol"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is an uncommon cutaneous T-cell lymphoma commonly seen in middle-aged females. Lupus panniculitis (LP) is a close differential of SPTCL and the clinical, histological, and immunohistochemical profiles of these two mimics fairly overlap, making differentiation challenging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study attempts to see if there is any difference in the cellular myelocytomatosis oncogene (c-MYC) expression of both entities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>From the electronic archive of the Department of Histopathology, all cases of SPTCL and LP diagnosed between 2015 and 2022 were retrieved. The c-MYC IHC was performed on nine SPTCL biopsies available from seven patients and eleven LP cases. The percentage of c-MYC-positive cells was quantified and compared between the two groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The mean age of patients with SPTCL and LP was 27.7 years (range: 10-50 years) and 35.9 years (range: 18-62 years), respectively. The c-MYC positivity was higher in cases of SPTCL, ranging from 0.5-22% with a mean of 10.6% and a median of 9%. The LP cases had a lower positivity rate with a range of 0-8% with a mean of 1.9% and a median of 1.2% (p value 0.0005). Additionally, c-MYC positivity was more pronounced in areas with fat entrapment, i.e., in atypical lymphocytes rimming individual fat cells with apoptotic debris.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Limitations<\/jats:title>\n                    <jats:p>The limitations include small sample size, absence of FISH studies in all cases and non availability of T cell receptor analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study highlights the importance of the IHC of c-MYC in diagnosing SPTCL vs. LP. The higher percentage of c-MYC-positive atypical cells in SPTCL suggests that this oncoprotein may have a significant involvement in the pathogenesis of SPTCL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.25259\/ijdvl_786_2025","type":"journal-article","created":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T07:22:46Z","timestamp":1761549766000},"page":"364-370","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["c-MYC expression analysis by immunohistochemistry in cases of subcutaneous panniculitis T-cell lymphoma and lupus panniculitis"],"prefix":"10.25259","volume":"92","author":[{"given":"Rashmi P","family":"Joshi","sequence":"first","affiliation":[{"name":"Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debajyoti","family":"Chatterjee","sequence":"additional","affiliation":[{"name":"Department of Histopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uma Nahar","family":"Saikia","sequence":"additional","affiliation":[{"name":"Department of Histopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dipankar","family":"De","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2025,10,14]]},"reference":[{"key":"10.25259\/IJDVL_786_2025\/ref-1","article-title":"Subcutaneous panniculiis-like T cell lymphoma","volume-title":"WHO classification of tumours editorial board. 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