{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T10:28:14Z","timestamp":1769164094081,"version":"3.49.0"},"reference-count":16,"publisher":"Scientific Scholar","content-domain":{"domain":["ijdvl.com"],"crossmark-restriction":true},"short-container-title":["IJDVL"],"abstract":"\nObjectives<\/jats:title>\nThis cross-sectional study was designed to assess the clinical profile and frequency of associated autoantibodies in all consecutive patients classified as systemic sclerosis (SSc) at Medanta\u2014the Medicity Hospital, Gurgaon, India.<\/jats:p>\n<\/jats:sec>\n\nMethods<\/jats:title>\nBetween August 2017 and July 2019, we identified a total of 119 consecutive patients meeting the American College of Rheumatology\/European League Against Rheumatism (ACR\/EULAR) 2013 criteria for SSc and 106 patients consented to this study. Their clinical and serological data at the time of enrolment were analysed.<\/jats:p>\n<\/jats:sec>\n\nResults<\/jats:title>\nOur cohort had a mean age at symptom onset of 40 \u00b1 13 years with a median symptom duration of 6 years. We had 76 patients (71.7%) with interstitial lung disease (ILD), which was a higher proportion compared to European cohorts. 62 patients (58.5%) had diffuse cutaneous involvement which was significantly associated with anti-Scl70 antibodies (p < 0.001), digital ulcers (p = 0.039) and the presence of ILD (p = 0.004). 65 patients (61.3%) had anti-Scl70 and 15 patients (14.2%) had anti-centromere (anti-CENP) antibodies. Scl70 positivity was associated with the presence of ILD (p < 0.001) and digital ulcers (p = 0.01). Centromere antibodies had a negative association with ILD (p < 0.001), but was a risk factor for calcinosis (p < 0.001) and pulmonary arterial hypertension (PAH) (p = 0.01). The combination of diffuse cutaneous disease and Scl70 antibodies was the strongest predictor of ILD and digital ulcers (p = 0.015). sm\/RMP, RNP68 and Ku antibodies correlated with musculoskeletal involvement (p < 0.01), while all seven of the patients with Pm\/Scl antibodies had ILD. Renal involvement was noted in only two patients.<\/jats:p>\n<\/jats:sec>\n\nLimitations<\/jats:title>\nA single-centre study may not capture the true prevalence of disease characteristics in the population. Referral bias for patients with diffuse cutaneous disease has been noted. Data on RNA-Polymerase antibodies have not been provided.<\/jats:p>\n<\/jats:sec>\n\nConclusion<\/jats:title>\nNorth Indian patients have some characteristic differences in disease phenotype as compared to their Caucasian counterparts with a larger proportion of patients presenting with ILD and Scl70 antibodies. Antibodies against Ku, RNP and Pm\/Scl occur in a minority of patients, but may be associated with musculoskeletal features.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/ijdvl_901_2022","type":"journal-article","created":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T04:23:00Z","timestamp":1688358180000},"page":"440-446","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical and autoantibody profiles of systemic sclerosis patients: A cross-sectional study from North India"],"prefix":"10.25259","volume":"90","author":[{"given":"Shounak","family":"Ghosh","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Medanta\u2014the Medicity, Gurgaon, Haryana, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dhaval","family":"Tanna","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Medanta\u2014the Medicity, Gurgaon, Haryana, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaustubh","family":"Telang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Medanta\u2014the Medicity, Gurgaon, Haryana, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahzeene","family":"Dhuria","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Medanta\u2014the Medicity, Gurgaon, Haryana, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajiva","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Medanta\u2014the Medicity, Gurgaon, Haryana, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2023,7,1]]},"reference":[{"key":"10.25259\/IJDVL_901_2022\/ref-1","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1097\/BOR.0b013e32834ff2e8","article-title":"Epidemiology of systemic sclerosis: Incidence, prevalence, survival, risk factors, malignancy, and environmental triggers","volume":"24","author":"Barnes","year":"2012","journal-title":"Curr Opin Rheumatol"},{"key":"10.25259\/IJDVL_901_2022\/ref-2","doi-asserted-by":"publisher","first-page":"2246","DOI":"10.1002\/art.11073","article-title":"Prevalence, incidence, survival, and disease characteristics of systemic sclerosis in a large US population","volume":"48","author":"Mayes","year":"2003","journal-title":"Arthritis Rheum"},{"key":"10.25259\/IJDVL_901_2022\/ref-3","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.1002\/art.1780390814","article-title":"Increased prevalence of systemic sclerosis in a Native American tribe in Oklahoma. 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