{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T17:07:25Z","timestamp":1789578445548,"version":"build-2803163510"},"reference-count":67,"publisher":"Scientific Scholar","content-domain":{"domain":["ijdvl.com"],"crossmark-restriction":true},"short-container-title":["IJDVL"],"abstract":"<jats:p>\n                    Hailey\u2013Hailey disease (HHD) is an autosomal dominant genetic disorder of keratinocyte adhesion. It occurs due to mutations in ATP2C1, a gene on chromosome 3q21-24 which encodes human secretory pathway Ca\n                    <jats:sup>2+<\/jats:sup>\n                    \/Mn\n                    <jats:sup>2+<\/jats:sup>\n                    ATPase isoform 1, a calcium pump on the Golgi apparatus membrane. Recently, there has been a focus on certain pro-inflammatory cytokines such as IL-6 and IL-8 which play a role in HHD. Various triggers include excessive heat, menstruation, pregnancy, sweating, friction, exposure to sunlight and super\ufb01cial infections. The therapy of the disorder is better understood by the varied pathogenetic steps and we aimed to comprehensively search for the various medical therapies used in HHD and align them with the existing knowledge on the pathogenesis and delineate them according to their major mode of action.\n                  <\/jats:p>","DOI":"10.25259\/ijdvl_906_2024","type":"journal-article","created":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T05:20:18Z","timestamp":1727155218000},"page":"462-469","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Therapeutic agents for Hailey-Hailey disease: A narrative review"],"prefix":"10.25259","volume":"91","author":[{"given":"Kabir","family":"Sardana","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Leprosy, Atal Bihari Vajpayee Institute of Medical Sciences & Dr Ram Manohar Lohia Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhinav","family":"Bansal","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprosy, Atal Bihari Vajpayee Institute of Medical Sciences & Dr Ram Manohar Lohia Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aishwarya","family":"Muddebihal","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprosy, Atal Bihari Vajpayee Institute of Medical Sciences & Dr Ram Manohar Lohia Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ananta","family":"Khurana","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprosy, Atal Bihari Vajpayee Institute of Medical Sciences & Dr Ram Manohar Lohia Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2024,9,24]]},"reference":[{"key":"10.25259\/IJDVL_906_2024\/ref-1","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1111\/j.1365-2133.2004.05904.x","article-title":"Calcium pumps and keratinocytes: lessons from Darier\u2019s disease and Hailey-Hailey disease","volume":"150","author":"Dhitavat","year":"2004","journal-title":"Br J Dermatol"},{"key":"10.25259\/IJDVL_906_2024\/ref-2","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1186\/s12881-020-01056-4","article-title":"Identification of ATP2C1 mutations in the patients of Hailey-Hailey disease","volume":"21","author":"Li","year":"2020","journal-title":"BMC Med Genet"},{"key":"10.25259\/IJDVL_906_2024\/ref-3","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1007\/s00403-014-1506-2","article-title":"Hailey-Hailey disease: investigation of a possible compensatory SERCA2 up-regulation and analysis 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