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This article is a qualitative review of the literature after the introduction of multidrug therapy, aiming to bring consensus related to the clinical, laboratory and histopathological diagnostic criteria of the disease and its management.<\/jats:p>","DOI":"10.25259\/ijdvl_909_19","type":"journal-article","created":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T09:49:34Z","timestamp":1634118574000},"page":"464-477","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Lucio\u2019s phenomenon: A systematic literature review of definition, clinical features, histopathogenesis and management"],"prefix":"10.25259","volume":"88","author":[{"given":"Marco Andrey Cipriani","family":"Frade","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro S.","family":"Coltro","sequence":"additional","affiliation":[{"name":"Department of Surgery and Anatomy, Division of Plastic Surgery, Public Oral Health and Forensic Dentistry, School of Dentistry of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred Bernardes","family":"Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grazielle S.","family":"Hor\u00e1cio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ant\u00f4nio A.","family":"Neto","sequence":"additional","affiliation":[{"name":"Department of Surgery and Anatomy, Division of Plastic Surgery, Public Oral Health and Forensic Dentistry, School of Dentistry of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinicius Z.","family":"da Silva","sequence":"additional","affiliation":[{"name":"Department of Surgery and Anatomy, Division of Plastic Surgery, Public Oral Health and Forensic Dentistry, School of Dentistry of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrezza T.","family":"Westin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francielle R.","family":"Guimar\u00e3es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara M. 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