{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T13:11:07Z","timestamp":1724764267663},"reference-count":9,"publisher":"Scientific Scholar","content-domain":{"domain":["ijdvl.com"],"crossmark-restriction":true},"short-container-title":["IJDVL"],"abstract":"\nBackground<\/jats:title>\nPlantar keratoderma is a common finding in pachyonychia congenita, significantly impairing ambulation and quality of life. Due to the variation of pain reporting in pachyonychia congenita clinical studies, it is difficult to evaluate the efficacy of treatment outcomes for painful plantar keratodermas.<\/jats:p>\n<\/jats:sec>\n\nObjectives<\/jats:title>\nTo objectively analyse associations between plantar pain and activity levels in pachyonychia congenita patients using a wristband tracker.<\/jats:p>\n<\/jats:sec>\n\nMethods<\/jats:title>\nPachyonychia congenita patients and matched normal controls wore wristband activity trackers and completed a daily digital survey to record their highest and total pain scores (0\u201310 scale) each day for 28 consecutive days during four different seasons.<\/jats:p>\n<\/jats:sec>\n\nResults<\/jats:title>\nTwenty four participants (12 pachyonychia congenita patients and 12 matched normal controls) completed the study. Pachyonychia congenita patients walked 1801.30 fewer steps\/day (95% CI, \u22123666.4, 64.1) than normal controls (P<\/jats:italic> = 0.072) and had greater average total [5.26; SD, 2.10] and highest (6.92; SD, 2.35) daily pain than normal controls [0.11 (SD, 0.47), 0.30 (SD, 0.22), respectively] (P<\/jats:italic> < 0.001, both). On average, for each one unit increase in daily highest pain level, pachyonychia congenita activity decreased 71.54 steps\/day (SE, 38.90, P<\/jats:italic> = 0.066).<\/jats:p>\n<\/jats:sec>\n\nLimitation<\/jats:title>\nThe study had a small number of participants, limiting statistical power. Only pachyonychia congenita patients, ages 18 years or older, with keratin 6a, keratin 16, and keratin 17 mutations were included, limiting generalizability.<\/jats:p>\n<\/jats:sec>\n\nConclusion<\/jats:title>\nPachyonychia congenita patients were less active with significantly higher pain than normal controls. There was an inverse correlation between pain and activity. Our findings suggest that wristband tracker technology may be used to evaluate treatment efficacy in future trials on severe plantar pain; therapeutic interventions that decrease plantar pain should correlate with significant increases in activity using wristband trackers.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/ijdvl_939_2022","type":"journal-article","created":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T09:41:57Z","timestamp":1683538917000},"page":"850-853","update-policy":"http:\/\/dx.doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Walking a day in a pachyonychia congenita patient\u2019s shoes: Impact on plantar pain and activity levels measured with wristband activity trackers"],"prefix":"10.25259","volume":"89","author":[{"given":"Shari R.","family":"Lipner","sequence":"first","affiliation":[{"name":"Department of Dermatology, Weill Cornell Medical College, New York, United States of America"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julianne M.","family":"Falotico","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Renaissance School of Medicine, Stony Brook University, Stony Brook, United States of America"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin T.","family":"Matushansky","sequence":"additional","affiliation":[{"name":"Department of Medicine, Columbia University, New York, United States of America"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holly","family":"Evans","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Pachyonychia Congenita Project, Salt Lake City, Utah, United States of America"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janice","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Pachyonychia Congenita Project, Murray, Utah, United States of America"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. David","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Utah School of Medicine, Murray, Utah, United States of America"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2023,5,3]]},"reference":[{"key":"10.25259\/IJDVL_939_2022\/ref-1","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1038\/jid.2011.59","article-title":"The phenotypic and molecular genetic features of pachyonychia congenita","volume":"131","author":"McLean","year":"2011","journal-title":"J Invest Dermatol"},{"key":"10.25259\/IJDVL_939_2022\/ref-2","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1111\/ced.14569","article-title":"Identification of clinically useful predictive genetic variants in pachyonychia congenita","volume":"46","author":"Samuelov","year":"2021","journal-title":"Clin Exp Dermatol"},{"key":"10.25259\/IJDVL_939_2022\/ref-3","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1159\/000513828","article-title":"Distinctions in the management, patient impact, and clinical profiles of pachyonychia congenita subtypes","volume":"7","author":"Wu","year":"2021","journal-title":"Skin Appendage Disord"},{"key":"10.25259\/IJDVL_939_2022\/ref-4","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1111\/bjd.18033","article-title":"Pathophysiology of pachyonychia congenita\u2010associated palmoplantar keratoderma: New insights into skin epithelial homeostasis and avenues for treatment","volume":"182","author":"Zieman","year":"2020","journal-title":"Br J Dermatol"},{"key":"10.25259\/IJDVL_939_2022\/ref-5","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1111\/jdv.12098","article-title":"Best treatment practices for pachyonychia congenita","volume":"28","author":"Goldberg","year":"2014","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.25259\/IJDVL_939_2022\/ref-6","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/j.1087-0024.2005.10202.x","article-title":"Clinical and pathological features of pachyonychia congenita","volume":"10","author":"Leachman","year":"2005","journal-title":"J Investig Dermatol Symp Proc"},{"key":"10.25259\/IJDVL_939_2022\/ref-7","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1016\/j.jaad.2011.12.009","article-title":"A review of the clinical phenotype of 254 patients with genetically confirmed pachyonychia congenita","volume":"67","author":"Eliason","year":"2012","journal-title":"J Am Acad Dermatol"},{"key":"10.25259\/IJDVL_939_2022\/ref-8","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1111\/bjd.17880","article-title":"Pain mechanisms in hereditary palmoplantar keratodermas","volume":"182","author":"Weinberg","year":"2020","journal-title":"Br J Dermatol"},{"key":"10.25259\/IJDVL_939_2022\/ref-9","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1111\/j.1365-2133.2005.07115.x","article-title":"Treatment of pachyonychia congenita with plantar injections of botulinum toxin","volume":"154","author":"Swartling","year":"2006","journal-title":"Br J Dermatol"}],"container-title":["Indian Journal of Dermatology, Venereology and Leprology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ijdvl.com\/walking-a-day-in-a-pachyonychia-congenita-patients-shoes-impact-on-plantar-pain-and-activity-levels-measured-with-wristband-activity-trackers\/","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ijdvl.com\/walking-a-day-in-a-pachyonychia-congenita-patients-shoes-impact-on-plantar-pain-and-activity-levels-measured-with-wristband-activity-trackers\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T05:48:51Z","timestamp":1698472131000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ijdvl.com\/walking-a-day-in-a-pachyonychia-congenita-patients-shoes-impact-on-plantar-pain-and-activity-levels-measured-with-wristband-activity-trackers\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,3]]},"references-count":9,"alternative-id":["10.25259\/IJDVL_939_2022"],"URL":"https:\/\/doi.org\/10.25259\/ijdvl_939_2022","relation":{},"ISSN":["0973-3922","0378-6323"],"issn-type":[{"value":"0973-3922","type":"electronic"},{"value":"0378-6323","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5,3]]},"article-number":"850"}}