{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T16:35:45Z","timestamp":1788280545932,"version":"build-2803163510"},"reference-count":15,"publisher":"Scientific Scholar","content-domain":{"domain":["ijdvl.com"],"crossmark-restriction":true},"short-container-title":["IJDVL"],"abstract":"<jats:sec id=\"st1\">\n<jats:title>Background:<\/jats:title>\n<jats:p>Port-wine stains occur in 0.3\u20130.5% newborns, mainly on the face and neck. Pulsed dye laser is recognized as the gold standard treatment; nevertheless, it is associated with a low cure rate and a high recurrence rate.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st2\">\n<jats:title>Aims:<\/jats:title>\n<jats:p>This study aims to evaluate the efficacy of hemoporfin photodynamic therapy for pulsed dye laser-resistant port-wine stains in children.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st3\">\n<jats:title>Methods:<\/jats:title>\n<jats:p>We studied 107 children who received hemoporfin photodynamic therapy for port-wine stains on the face and neck that were resistant to pulsed dye laser. After intravenous injection of 5 mg\/kg hemoporfin, the local lesion was irradiated with 532 nm LED green light for 20 min with a power density of 80\u2013100 mW\/cm<jats:sup>2<\/jats:sup>. A total of 65 patients were given a second treatment after eight weeks. The efficacy and therapeutic responses were recorded at four days and eight weeks after each treatment.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st4\">\n<jats:title>Results:<\/jats:title>\n<jats:p>The efficacy was positively correlated with the number of treatments received; two treatment sessions yielded significantly better results compared to a single treatment with a response rate of 96.9%, a significant response rate of 50.8% and a cure rate of 21.5%, respectively (<jats:italic>P<\/jats:italic> &lt; 0.001). After two treatment sessions, the efficacy was negatively correlated with age (<jats:italic>P<\/jats:italic> = 0.04). The efficacy for port-wine stains located on the lateral part was better than that of the central face (<jats:italic>P<\/jats:italic> = 0.04). The efficacy for the pink type was better than that for the red and purple types (<jats:italic>P<\/jats:italic> = 0.03). No allergic or systematic adverse reactions were reported.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st5\">\n<jats:title>Limitations:<\/jats:title>\n<jats:p>No objective measurement data were available.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st6\">\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>Hemoporfin photodynamic therapy is effective and safe for pulsed dye laser-resistant facial port-wine stains in children.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/ijdvl_976_20","type":"journal-article","created":{"date-parts":[[2021,10,16]],"date-time":"2021-10-16T08:04:21Z","timestamp":1634371461000},"page":"275-275","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Efficacy of hemoporfin photodynamic therapy for pulsed dye laser-resistant facial port-wine stains in 107 children: A retrospective study"],"prefix":"10.25259","volume":"88","author":[{"given":"Li-Chao","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-Bo","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Ye","family":"Bi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2021,10,15]]},"reference":[{"key":"10.25259\/IJDVL_976_20\/ref-1","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.pdpdt.2018.09.012","article-title":"Clinical study on hemoporfin PDT for infant facial port-wine stains","volume":"25","author":"Zhang","year":"2019","journal-title":"Photodiagnosis Photodyn 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vessels","volume":"34","author":"Kelly","year":"2004","journal-title":"Lasers Surg Med"},{"key":"10.25259\/IJDVL_976_20\/ref-11","doi-asserted-by":"publisher","first-page":"1603","DOI":"10.1111\/j.1524-4725.2011.02129.x","article-title":"Twenty years of clinical experience with a new modality of vascular-targeted photodynamic therapy for port wine stains","volume":"37","author":"Qiu","year":"2011","journal-title":"Dermatol Surg"},{"key":"10.25259\/IJDVL_976_20\/ref-12","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1111\/j.1600-0781.2010.00555.x","article-title":"Efficacy and safety of hemoporfin in photodynamic therapy for port-wine stain: A multicenter and open-labeled phase IIa study","volume":"27","author":"Zhao","year":"2011","journal-title":"Photodermatol Photoimmunol Photomed"},{"key":"10.25259\/IJDVL_976_20\/ref-13","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1055\/s-0032-1329936","article-title":"Port-wine stain laser treatments and novel 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