{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T14:01:01Z","timestamp":1793196061446,"version":"4.5.0"},"reference-count":89,"publisher":"Scientific Scholar","content-domain":{"domain":["ijmr.org.in"],"crossmark-restriction":true},"short-container-title":["IJMR"],"abstract":"<jats:sec>\n                    <jats:title>Background &amp; objectives<\/jats:title>\n                    <jats:p>Scrub typhus is an emerging mite-borne zoonotic infection that has been overlooked, despite being one of the most widespread severe vector-borne diseases. With an estimated one billion people at risk worldwide and one million annual cases, it poses a significant public health concern. While various studies have investigated the prevalence of scrub typhus in different regions of India, a comprehensive regional systematic review and meta-analysis on the seropositivity of scrub typhus among acute febrile cases has been lacking. To address this gap, we conducted a systematic review and meta-analysis to compile information on the current seroprevalence of scrub typhus in acute febrile illness cases in India.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A literature search of multiple databases on prevalence of scrub typhus in acute febrile illness in India, 60 eligible studies out of 573 studies. The prevalence of individual studies was double arcsine transformed, and the pooled prevalence was calculated using inverse variance method.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, these studies encompassed 34,492 febrile cases. The overall seroprevalence of scrub typhus among acute febrile illness cases in India was found to be 26.41 per cent [95% confidence interval (CI): 22.03-31.03]. Additionally, the pooled case fatality rate (based on data from six studies) among scrub typhus-positive cases yielded a case fatality rate of 7.69 per cent (95% CI: 4.37-11.72).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation &amp; conclusions<\/jats:title>\n                    <jats:p>This meta-analysis shows that scrub typhus is a significant health threat in India. Preventive measures to control scrub typhus need to be given priority.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.25259\/ijmr_1442_23","type":"journal-article","created":{"date-parts":[[2024,8,17]],"date-time":"2024-08-17T09:16:55Z","timestamp":1723886215000},"page":"601-618","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Unveiling the burden of scrub typhus in acute febrile illness cases across India: A systematic review &amp; meta-analysis"],"prefix":"10.25259","volume":"159","author":[{"given":"Gayatri","family":"Sondhiya","sequence":"first","affiliation":[{"name":"ICMR-National Institute of Research in Tribal Health, Jabalpur, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haranahally Vasanthachar","family":"Manjunathachar","sequence":"additional","affiliation":[{"name":"ICMR-National Institute of Traditional Medicine, Belagavi, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pushpendra","family":"Singh","sequence":"additional","affiliation":[{"name":"ICMR-National Institute of Research in Tribal Health, Jabalpur, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravindra","family":"Kumar","sequence":"additional","affiliation":[{"name":"ICMR-National Institute of Research in Tribal Health, Jabalpur, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2024,8,17]]},"reference":[{"key":"10.25259\/ijmr_1442_23\/ref-1","doi-asserted-by":"publisher","first-page":"e1006657","DOI":"10.1371\/journal.ppat.1006657","article-title":"Orientia tsutsugamushi: A neglected but fascinating obligate intracellular bacterial pathogen","volume":"13","author":"Salje","year":"2017","journal-title":"PLoS pathogens"},{"key":"10.25259\/ijmr_1442_23\/ref-2","doi-asserted-by":"publisher","first-page":"2148","DOI":"10.3201\/eid2609.200918","article-title":"Molecular description of a novel orientia species causing scrub typhus in Chile","volume":"26","author":"Abarca","year":"2020","journal-title":"Emerg Infect Dis"},{"key":"10.25259\/ijmr_1442_23\/ref-3","doi-asserted-by":"publisher","first-page":"e0006062","DOI":"10.1371\/journal.pntd.0006062","article-title":"A review of the global epidemiology of scrub typhus","volume":"11","author":"Xu","year":"2017","journal-title":"PLoS Negl Trop Dis"},{"key":"10.25259\/ijmr_1442_23\/ref-4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13071-014-0608-1","article-title":"Detection of orientiasp. 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