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Compared with placebo, L-arginine and vitamin B and vitamin C and vitamin E (L-arginine-VB-VC-VE) [Odds ratio (OR)=0.33, 95% confidence interval (CI) (0.20, 0.54)], linoleic-acid-calcium (OR=0.16, 95% CI 0.041, 0.50), vitamin D (VD) (OR=0. 34, 95% CI 0.17, 0.65), and calcium (OR=0.77, 95% CI 0.65, 0.91) were more effective in preventing preeclampsia. The first three nutritional supplements were superior to calcium. There was no difference among these three supplements. None of the four nutritional supplements (calcium, phytonutrient, VC, and VC-VE) were effective in preventing gestational hypertension. Oral calcium, L-arginine-VB-VC-VE, linoleic-acid-calcium, and VD could be effective approaches to prevent preeclampsia.<\/jats:p>","DOI":"10.25259\/ijmr_1582_2025","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T05:39:26Z","timestamp":1782279566000},"page":"53-62","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Nutritional supplements for preventing preeclampsia: A network meta-analysis"],"prefix":"10.25259","volume":"164","author":[{"given":"Changxiu","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics, Linyi People\u2019s Hospital, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuiping","family":"You","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Linyi People\u2019s Hospital, Shandong, 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