{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T06:15:58Z","timestamp":1773036958914,"version":"3.50.1"},"reference-count":20,"publisher":"Scientific Scholar","content-domain":{"domain":["ijmr.org.in"],"crossmark-restriction":true},"short-container-title":["Indian J Med Res"],"abstract":"<jats:sec>\n<jats:title>Background &amp; objectives<\/jats:title>\n<jats:p>Availability of sweat chloride analysis, the gold standard test for diagnosis of Cystic Fibrosis (CF) faces significant challenges in India. This study aimed to compare sweat conductivity using Sweat-Chek\u2122 Sweat Analyzer against sweat chloride analysis using the 926 Sherwood chloride analyser and assess if sweat conductivity test can guide CF diagnosis in resource-poor settings.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>In this retrospective study sweat chloride analysis and sweat conductivity were simultaneously performed on samples collected <jats:italic>via<\/jats:italic> Macroduct\u00ae system from patients referred for sweat testing. CF diagnosis was based on sweat chloride levels: \u226560 mmol\/l confirmed CF, 30-59 mmol\/l was borderline, and &lt;30 mmol\/l excluded CF. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV), and area under curve (AUC) were calculated <jats:italic>via<\/jats:italic> ROC curve. Spearman\u2019s rho was employed to analyse the correlation between methods.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Both tests were performed on 118 children of which 106 samples were adequately collected. CF was diagnosed in 11 children. Sweat conductivity \u2265 80 mmol\/l diagnosed CF with 100 per cent sensitivity, specificity, PPV, and NPV. Likewise, a value \u2264 49 mmol\/l predicted absence of CF with 100 per cent sensitivity, 91.36 per cent specificity, 78.13 per cent PPV, and 100 per cent NPV. Spearman\u2019s rho of 0.93 (<jats:italic>P<\/jats:italic>&lt; 0.001) showed a strong correlation between the two methods. Intermediate conductivity values also correlated well (rs 0.62, <jats:italic>P<\/jats:italic>&lt; 0.003) with intermediate sweat chloride levels.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Interpretations &amp; conclusions<\/jats:title>\n<jats:p>Sweat conductivity reliably identified CF in the study population including those children with borderline levels, suggesting the possibility of its use in resource-limited settings where sweat chloride analyzers are unavailable.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/ijmr_1754_2024","type":"journal-article","created":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T05:34:11Z","timestamp":1745645651000},"page":"207-214","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Sweat conductivity test - can it be a cheaper alternative to sweat chloride analysis for diagnosis of cystic fibrosis in low resource setting?"],"prefix":"10.25259","volume":"161","author":[{"given":"Arun","family":"Jose","sequence":"first","affiliation":[{"name":"Department of Clinical Biochemistry, Christian Medical College, Vellore, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priyanka","family":"Medhi","sequence":"additional","affiliation":[{"name":"Department of Child Health, Christian Medical College, Vellore, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sneha Deena","family":"Varkki","sequence":"additional","affiliation":[{"name":"Department of Child Health, Christian Medical College, Vellore, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thondaiman","family":"Loganathan","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Christian Medical College, Vellore, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela","family":"Christudoss","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Christian Medical College, Vellore, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reka","family":"Karuppusami","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Christian Medical College, Vellore, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2025,4,24]]},"reference":[{"key":"10.25259\/IJMR_1754_2024\/ref-1","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1126\/science.2570460","article-title":"Identification of the cystic fibrosis gene: Genetic 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