{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T17:03:31Z","timestamp":1793639011693,"version":"4.5.1"},"reference-count":33,"publisher":"Scientific Scholar","content-domain":{"domain":["ijmr.org.in"],"crossmark-restriction":true},"short-container-title":["Indian J Med Res"],"abstract":"<jats:sec>\n<jats:title>Background &amp; Objectives<\/jats:title>\n<jats:p>Multi-morbidity, characterised by the coexistence of two or more chronic conditions, significantly impacts critically ill patients. Among sepsis-associated acute kidney injury (SA-AKI) patients, multi-morbidity contributes to poor clinical outcomes, yet its prevalence and associated risk factors remain under-explored. This study examines the prevalence of multi-morbidity among SA-AKI patients in the intensive care unit (ICU) setting and identifies significant risk factors that influence outcomes.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>A cross-sectional study was conducted on 185 adult ICU patients with SA-AKI in a tertiary intensive care unit between January 2023 and January 2024. Risk factors, biochemical profiles, and clinical outcomes were analysed. Logistic regression was employed to identify predictors of multi-morbidity.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Among 185 SA-AKI patients, the prevalence of multi-morbidity was 38.9 per cent, with older age [\u226560 yr, adjusted odds ratio (AOR): 22.11, <jats:italic>P<\/jats:italic>&lt;0.0001), chloride imbalance (AOR: 0.42, <jats:italic>P<\/jats:italic>=0.023), and albumin imbalance (AOR: 0.10, <jats:italic>P<\/jats:italic>=0.018) identified as significant risk factors. The most common comorbidities were hypertension (52.4%) and diabetes mellitus (46.5%). Electrolyte imbalances such as hyponatremia (34.1%) and hypoalbuminemia (77.8%) were prevalent. Patients with multimorbidity had higher mechanical ventilation rates (62.5% <jats:italic>vs<\/jats:italic>. 28.3%) and hospital mortality rates (60.6% <jats:italic>vs<\/jats:italic>. 23.5%, <jats:italic>P<\/jats:italic>&lt;0.001). Renal replacement therapy use was not significantly different between groups.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Interpretation &amp; conclusions<\/jats:title>\n<jats:p>The study highlights the high burden of multi-morbidity in SA-AKI patients, with significant implications for clinical management and outcomes. Comprehensive strategies are needed to address the associated risk factors and improve care in this population.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/ijmr_2037_2024","type":"journal-article","created":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T16:27:51Z","timestamp":1754670471000},"page":"665-671","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Prevalence &amp; risk factors of multi-morbidity in critically ill patients with sepsis-associated acute kidney injury (SA-AKI)"],"prefix":"10.25259","volume":"161","author":[{"given":"Sai Sreeharshita","family":"Malla","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Indian Institute of Public Health, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkat Raman","family":"Kola","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Yashoda Hospitals, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varun","family":"Agiwal","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Indian Institute of Public Health, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hira Ballabh","family":"Pant","sequence":"additional","affiliation":[{"name":"Department of E2E Fellowship, Indian Institute of Public Health, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2025,8,8]]},"reference":[{"key":"10.25259\/IJMR_2037_2024\/ref-1","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The third international consensus definitions for sepsis and septic shock 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