{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T10:15:20Z","timestamp":1788257720204,"version":"build-2803163510"},"reference-count":8,"publisher":"Scientific Scholar","content-domain":{"domain":["ijmr.org.in"],"crossmark-restriction":true},"short-container-title":["Indian J Med Res"],"abstract":"<jats:p>\n                    Sickle cell disease (SCD) is a major public health concern in central India. This study aims to estimate the prevalence of haemoglobinopathies, haematological variations, family screening status, prenatal diagnosis and pregnancy outcomes among pregnant women. A total of 11,602 pregnant women were screened between 2017 and 2022. Among the screened, the prevalence of sickle cell homozygous (SS) and sickle \u03b2-thalassemia (S\u03b2-thal.) was 0.25% and 0.38%, respectively. The haematological parameters differed significantly (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.05) between the phenotypic groups. In a retrospective analysis, we found that only 61.1% (n=204) of spouses and 42.5% (n=226) of children were screened for SCD. Pregnant women with SCD had longer hospital stays, a lower birth weight, a higher incidence of preterm birth, an increased likelihood of caesarean delivery, and a higher rate of blood transfusions. Our study highlights the importance of early screening for pregnant women for SCD.\n                  <\/jats:p>","DOI":"10.25259\/ijmr_255_2026","type":"journal-article","created":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T06:09:40Z","timestamp":1785564580000},"page":"489-492","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Burden of sickle cell disease among pregnant women in central India"],"prefix":"10.25259","volume":"164","author":[{"given":"Sayali C","family":"Tiwari","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine & Public Health, ICMR-Centre for Research Management and Control of Haemoglobinopathies, Chandrapur, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagaraj","family":"Jaganathasamy","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, ICMR-Centre for Research Management and Control of Haemoglobinopathies, Chandrapur, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chhedi Lal","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics, ICMR-Centre for Research Management and Control of Haemoglobinopathies, Chandrapur, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aruna Anil","family":"Jawade","sequence":"additional","affiliation":[{"name":"ICMR-National Institute for One Health, Nagpur, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagamuralidhar","family":"Merugu","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, ICMR-Centre for Research Management and Control of Haemoglobinopathies, Chandrapur, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pallavi","family":"Thaker","sequence":"additional","affiliation":[{"name":"Department of Haematogenetics, National Institute for Research on Blood and Immune Disorders, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhil","family":"Shinde","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine & Public Health, ICMR-Centre for Research Management and Control of Haemoglobinopathies, Chandrapur, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sneha","family":"Dadheech","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine & Public Health, ICMR-Centre for Research Management and Control of Haemoglobinopathies, Chandrapur, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinod","family":"Umare","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine & Public Health, ICMR-Centre for Research Management and Control of Haemoglobinopathies, Chandrapur, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Projyot Vijayrao","family":"Deshmukh","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine & Public Health, ICMR-Centre for Research Management and Control of Haemoglobinopathies, Chandrapur, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prabhakar","family":"Kedar","sequence":"additional","affiliation":[{"name":"Department of Haematogenetics, National Institute for Research on Blood and Immune Disorders, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malay B","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine & Public Health, ICMR-Centre for Research Management and Control of Haemoglobinopathies, Chandrapur, Maharashtra, India"},{"name":"Department of Pediatric Immunology & Leukocyte Biology, National Institute for Research on Blood and Immune Disorders, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manisha","family":"Madkaikar","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine & Public Health, ICMR-Centre for Research Management and Control of Haemoglobinopathies, Chandrapur, Maharashtra, India"},{"name":"Department of Pediatric Immunology & Leukocyte Biology, National Institute for Research on Blood and Immune Disorders, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2026,7,31]]},"reference":[{"key":"10.25259\/IJMR_255_2026\/ref-1","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1111\/1471-0528.13786","article-title":"Pregnancy outcomes in women with sickle-cell disease: A systematic review and meta-analysis","volume":"123","author":"Boafor","year":"2016","journal-title":"BJOG."},{"key":"10.25259\/IJMR_255_2026\/ref-2","doi-asserted-by":"publisher","first-page":"e2019040","DOI":"10.4084\/MJHID.2019.040","article-title":"Sickle cell disease and pregnancy","volume":"11","author":"Jain","year":"2019","journal-title":"Mediterr J Hematol Infect Dis."},{"key":"10.25259\/IJMR_255_2026\/ref-3","doi-asserted-by":"publisher","first-page":"c5132","DOI":"10.1136\/bmj.c5132","article-title":"Effectiveness of earlier antenatal screening for sickle cell disease and thalassaemia in primary care: Cluster randomized trial","volume":"341","author":"Dormandy","year":"2010","journal-title":"BMJ."},{"key":"10.25259\/IJMR_255_2026\/ref-4","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1136\/jclinpath-2019-206317","article-title":"Sickle cell disease and thalassaemia antenatal screening programme in England over 10 years","volume":"73","author":"Weil","year":"2020","journal-title":"J Clin Pathol."},{"key":"10.25259\/IJMR_255_2026\/ref-5","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1159\/000046576","article-title":"Feasibility of antenatal screening of beta-thalassemia in Mumbai, India","volume":"105","author":"Colah","year":"2001","journal-title":"Acta Haematol."},{"key":"10.25259\/IJMR_255_2026\/ref-6","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1136\/medethics-2013-101392","article-title":"Would you terminate a pregnancy affected by sickle cell disease? Analysis of views of patients in cameroon","volume":"40","author":"Wonkam","year":"2014","journal-title":"J Med Ethics."},{"key":"10.25259\/IJMR_255_2026\/ref-7","doi-asserted-by":"publisher","first-page":"26","DOI":"10.4314\/aipm.v7i2.64084","article-title":"Some ethical issues in the prenatal diagnosis of sickle cell anaemia","volume":"7","author":"Fadare","year":"2009","journal-title":"Ann Ib Postgrad Med."},{"key":"10.25259\/IJMR_255_2026\/ref-8","doi-asserted-by":"publisher","first-page":"441","DOI":"10.25259\/IJMR_1003_2024","article-title":"Prenatal hemoglobinopathy screening prevention in India: A cross-sectional study","volume":"161","author":"Agarwal","year":"2025","journal-title":"Indian J Med Res."}],"container-title":["The Indian Journal of Medical Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/ijmr.org.in\/burden-of-sickle-cell-disease-among-pregnant-women-in-central-india\/","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/ijmr.org.in\/burden-of-sickle-cell-disease-among-pregnant-women-in-central-india\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T09:34:53Z","timestamp":1788255293000},"score":1,"resource":{"primary":{"URL":"http:\/\/ijmr.org.in\/burden-of-sickle-cell-disease-among-pregnant-women-in-central-india\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,31]]},"references-count":8,"alternative-id":["10.25259\/IJMR_255_2026"],"URL":"https:\/\/doi.org\/10.25259\/ijmr_255_2026","relation":{},"ISSN":["0971-5916"],"issn-type":[{"value":"0971-5916","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7,31]]},"article-number":"489"}}