{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T16:31:52Z","timestamp":1781109112881,"version":"3.54.1"},"reference-count":27,"publisher":"Scientific Scholar","content-domain":{"domain":["ijmr.org.in"],"crossmark-restriction":true},"short-container-title":["Indian J Med Res"],"abstract":"\nBackground & objectives<\/jats:title>\nCardiovascular diseases (CVDs) are a leading cause of mortality worldwide. The aim of this investigation was to study the role of biological markers in predicting the risk of carotid and coronary artery atherosclerosis.<\/jats:p>\n<\/jats:sec>\n\nMethods<\/jats:title>\nA total of 161 males in the age group of 30-65 yr were included in this study. All participants underwent biochemical analyses [cholesterol, low density lipoprotein cholesterol (LDL-C), triglycerides, glucose, (interleukin) IL-8, IL-10, (proprotein convertase inhibitors subtilisin\/kexin type 9) PCSK9, sortilin, creatinine]; ECG; echocardiography; coronary angiography; ultrasound doppler of brachiocephalic arteries. Based on PCSK9 levels, participants were divided into four groups: group 1, n=41 individuals with PCSK9 level of 100-250 ng\/ml; group 2, n=37 individuals with PCSK9 level of 251-400 ng\/ml; group 3, n=51 individuals with PCSK9 level of 401\u2013600 ng\/ml and group 4, n=32 individuals with PCSK9 level of 601-900 ng\/ml.<\/jats:p>\n<\/jats:sec>\n\nResults<\/jats:title>\nSortilin level was the highest in group 2. Group 3 individuals had the highest level of IL-8. Correlation analysis of the entire data set revealed the relationship of relative left ventricular thickness index with age, cardiovascular risk, body mass index, intima-media thickness and left ventricular mass index; sortilin had a negative relationship of weak strength with age and smoking, a direct relationship between the risk of cardiovascular complications and with IL-10.<\/jats:p>\n<\/jats:sec>\n\nInterpretation & conclusions<\/jats:title>\nSortilin is the innovative marker of CVDs. In the present investigation, we demonstrated the clear increase in the inflammatory markers (IL-8) in individuals with subclinical atherosclerosis. This fact can be explained by the oxygen stress activation. In individuals with coronary artery stenosis (50% and more), the increase in IL-10 levels demonstrates, to our opinion, the activation of antioxidant protection activation.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/ijmr_652_22","type":"journal-article","created":{"date-parts":[[2024,8,3]],"date-time":"2024-08-03T19:52:26Z","timestamp":1722714746000},"page":"511-518","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Diagnostic utility of sortilin & other biomarkers in the diagnosis of carotid & coronary atherosclerosis in individuals with arterial hypertension"],"prefix":"10.25259","volume":"159","author":[{"given":"Yulia","family":"Vukolova","sequence":"first","affiliation":[{"name":"Chair of Internal Medicine, International Centre for Education and Research in Cardiovascular Pathology and Cardiovisualization, Samara State Medical University, Samara, Russian Federation, 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