{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:55:34Z","timestamp":1790664934549,"version":"4.1.0"},"reference-count":13,"publisher":"Scientific Scholar","content-domain":{"domain":["ijmr.org.in"],"crossmark-restriction":true},"short-container-title":["Indian J Med Res"],"abstract":"\n Background and objectives<\/jats:title>\n Autonomic dysfunction plays a key role in blood pressure regulation, and heart rate variability (HRV) is a sensitive non-invasive marker of autonomic function. This study aimed to compare HRV among newly detected hypertensive and normotensive adults and to examine the association of HRV parameters with blood pressure levels.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This hospital-based case\u2013control study included 52 participants (26 hypertensives and 26 normotensives). Time-domain HRV parameters, standard deviation of all normal-to-normal RR intervals (SDNN), and root mean square of successive differences (RMSSD) and frequency-domain parameters, low frequency (LF), high frequency (HF), and LF\/HF ratio, were derived from electrocardiographic recordings. HRV parameters were compared between normotensive and hypertensive groups. Correlation with blood pressure and LF\/HF was assessed using Spearman\u2019s correlation, and logistic regression was used to examine the independent association between HRV and blood pressure parameters. Significance was set at 5% (\n P<\/jats:italic>\n < 0.05).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Time-domain measures of HRV among hypertensives had lower SDNN [28.16 (21.75\u201339.50) ms\n 2<\/jats:sup>\n ,\n P<\/jats:italic>\n =0.020], and lower RMSSD [16.88 (11.79\u201325.51) ms\n 2<\/jats:sup>\n ,\n P=<\/jats:italic>\n 0.003]. In the frequency domain, hypertensive individuals showed significantly lower HF [102.25 (53.73\u2013209.75),\n P<\/jats:italic>\n <0.001], and the LF\/HF ratio was significantly higher [1.94 (1.60\u20133.19),\n P<\/jats:italic>\n < 0.001]. LF\/HF ratio correlated positively with systolic (r\u209b=0.49) and diastolic blood pressure (r\u209b= 0.50), both\n P<\/jats:italic>\n <0.001. Multinomial logistic regression shows that higher systolic blood pressure was significantly associated with increased odds of sympathetic dominance [Odds ratio (OR) 1.09, 95% Confidence interval (CI) (1.04-1.15),\n P<\/jats:italic>\n <0.001].\n <\/jats:p>\n <\/jats:sec>\n \n Interpretation and conclusions<\/jats:title>\n Newly detected hypertensive adults demonstrated reduced parasympathetic activity and increased sympathetic dominance, with the LF\/HF ratio showing a significant positive association with systolic and diastolic blood pressure and independently predicted hypertension.<\/jats:p>\n <\/jats:sec>","DOI":"10.25259\/ijmr_697_2026","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T07:07:44Z","timestamp":1789110464000},"page":"652-655","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of heart rate variability in normotensive and newly detected hypertensive adults in a tertiary care hospital, Mysuru, Karnataka"],"prefix":"10.25259","volume":"164","author":[{"given":"Vishnupriya","family":"Gopinath","sequence":"first","affiliation":[{"name":"Department of Community Medicine, JSS Medical College, JSS Academy of Higher Education & Research, Mysuru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yashashwini","family":"Anethyar","sequence":"additional","affiliation":[{"name":"Department of Community Medicine, JSS Medical College, JSS Academy of Higher Education & Research, Mysuru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhu","family":"Basavegowda","sequence":"additional","affiliation":[{"name":"Department of Community Medicine, JSS Medical College, JSS Academy of Higher Education & Research, Mysuru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijaya","family":"Vageesh","sequence":"additional","affiliation":[{"name":"Department of Physiology, JSS Medical College, JSS Academy of Higher Education & Research, Mysuru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mounika Sree","family":"Manivasagan","sequence":"additional","affiliation":[{"name":"Department of Community Medicine, JSS Medical College, JSS Academy of Higher Education & Research, Mysuru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaithra","family":"Mallaiah","sequence":"additional","affiliation":[{"name":"Department of Community Medicine, JSS Medical College, JSS Academy of Higher Education & Research, Mysuru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uday","family":"Babu J.","sequence":"additional","affiliation":[{"name":"Department of Community Medicine, JSS Medical College, JSS Academy of Higher Education & Research, Mysuru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitta Shanmukha","family":"Srinivas","sequence":"additional","affiliation":[{"name":"Department of Community Medicine, JSS Medical College, JSS Academy of Higher Education & Research, Mysuru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2026,9,11]]},"reference":[{"key":"10.25259\/IJMR_697_2026\/ref-1","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.4103\/ijph.ijph_1257_23","article-title":"Hypertension in India: Navigating challenges and opportunities within universal health care","volume":"67","author":"Mandal","year":"2023","journal-title":"Indian J Public Health."},{"key":"10.25259\/IJMR_697_2026\/ref-2","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1161\/CIRCULATIONAHA.121.054602","article-title":"Harmonization of the American College of Cardiology\/American Heart Association and European Society of Cardiology\/European Society of Hypertension Blood Pressure\/Hypertension guidelines: 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Loayza","year":"2021","journal-title":"National Center for Health Statistics, Centers for Disease Control and Prevention."},{"key":"10.25259\/IJMR_697_2026\/ref-9","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1093\/oxfordjournals.eurheartj.a014868","article-title":"Heart rate variability: Standards of measurement, physiological interpretation, and clinical use","volume":"17","author":"Malik","year":"1996","journal-title":"European Heart J."},{"key":"10.25259\/IJMR_697_2026\/ref-10","doi-asserted-by":"publisher","first-page":"109","DOI":"10.7439\/ijbar.v5i2.659","article-title":"A study on analysis of heart rate variability in hypertensive individuals","volume":"5","author":"Natarajan","year":"2014","journal-title":"International Journal of Biomedical and Advanced Research."},{"key":"10.25259\/IJMR_697_2026\/ref-11","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1186\/s12933-021-01356-w","article-title":"Autonomic nervous system activity changes in patients 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