{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:07:36Z","timestamp":1790806056619,"version":"4.1.0"},"reference-count":29,"publisher":"Scientific Scholar","content-domain":{"domain":["ijmr.org.in"],"crossmark-restriction":true},"short-container-title":["Indian J Med Res"],"abstract":"<jats:sec>\n<jats:title>Background &amp; objectives<\/jats:title>\n<jats:p>The 2-chair test (2CT) has recently been proposed as a cardiopulmonary reserve-specific assessment of post-exercise recovery response. The objective of this study was to find out the most appropriate parameter of 2CT to categorically differentiate between \u2018normal\u2019 and symptomatic diseased population.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>In a prospective manner, we recruited a random cohort of symptomatic patients attending our outpatient department (OPD) with different respiratory diseases. We also selected another cohort of \u2018normal\u2019 persons from the willing attendants of the patients who had no symptoms and revealed no abnormality on chest X-ray and spirometry. Persons belonging to both groups were requested to mark their \u2018sickness\u2019 on a scale of 0 to 10 (\u20180\u2019 meaning none and \u201810\u2019 meaning maximum possible) under the PPSS (patient-perceived sickness score) and were subjected to perform 2CT. All the test variables related to pulse rate and peripheral capillary oxygen saturation (SpO<jats:sub>2<\/jats:sub>) changes were noted for both groups. The \u2018symptomatic\u2019 and \u2018normal\u2019 persons were compared based on the 2CT variables to find the well-performing discriminatory parameter.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>The comparison of 2CT variables of 419 patients and 30 \u2018normal\u2019 controls revealed that the PR change max, maximum SpO<jats:sub>2<\/jats:sub>, minimum-SpO<jats:sub>2<\/jats:sub>, and desat-max can significantly differentiate between the two. However, the desat-max correlated to the PPSS best. The VIP plot, primary component analysis, and pattern-hunter representation further substantiated this.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Interpretation &amp; conclusions<\/jats:title>\n<jats:p>The desat-max appears to be a sensitive parameter to differentiate the normal from the symptomatic diseased population. Further research in this area is warranted.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/ijmr_952_2024","type":"journal-article","created":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T14:50:46Z","timestamp":1743087046000},"page":"174-181","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The desat-max in 2-chair test appears to be a worthwhile parameter to identify sickness: An appraisal"],"prefix":"10.25259","volume":"161","author":[{"given":"Parthasarathi","family":"Bhattacharyya","sequence":"first","affiliation":[{"name":"Department of General Pulmonology, Institute of Pulmocare and Research, Kolkata, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wrick","family":"Chakraborty","sequence":"additional","affiliation":[{"name":"Department of General Pulmonology, Institute of Pulmocare and Research, Kolkata, India"},{"name":"Department of Biotechnology, St. Xavier\u2019s college (Autonomous), Kolkata, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mintu","family":"Paul","sequence":"additional","affiliation":[{"name":"Department of General Pulmonology, Institute of Pulmocare and Research, Kolkata, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayoni","family":"Sengupta","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Circulation, Institute of Pulmocare and Research, Kolkata, India"},{"name":"Department of Microbiology, Sister Nivedita University, Kolkata, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dipanjan","family":"Saha","sequence":"additional","affiliation":[{"name":"Department of General Pulmonology, Institute of Pulmocare and Research, Kolkata, 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