{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,20]],"date-time":"2025-07-20T03:59:05Z","timestamp":1752983945366,"version":"3.28.0"},"reference-count":23,"publisher":"Scientific Scholar","content-domain":{"domain":["indianjnephrol.org"],"crossmark-restriction":true},"short-container-title":["Indian J Nephrol"],"abstract":"\nBackground<\/jats:title>\nHIV infection is associated with a significant kidney disease burden. This study is aimed to screen for kidney disease in all HIV patients on highly active anti retroviral therapy (HAART), study clinico-histological correlation, and assess the impact of early diagnosis on the clinical course.<\/jats:p>\n<\/jats:sec>\n\nMaterials and Methods<\/jats:title>\nIt was a prospective, longitudinal study done in a tertiary care hospital. Adult HIV-infected patients, on HAART for at least 3 months, were screened for kidney disease. Kidney biopsy was done if indicated. Patients were treated as per standard guidelines. Results were analyzed at 3 months.<\/jats:p>\n<\/jats:sec>\n\nResults<\/jats:title>\nAmong 1600 patients, 966 were compliant with HAART and were tested. Two hundred and sixty-two patients completed the study duration. Out of these 262 patients 78.2% were receiving tenofovir-based ART regimen. Around 31.2% were hypertensive and 19.8% were diabetic. The mean eGFR was 57.5 \u00b1 24 mL\/min\/1.73 m2<\/jats:sup>. Around 19.8% had asymptomatic urine abnormalities, 40.1% had proteinuria, and 27.1% had AKI. Acute nephritic syndrome was seen in 16.4%, rapidly progressive renal failure (RPRF) in 13.3%, and CKD in 10.6% patients. Out of 74 patients who underwent biopsy, histology showed chronic tubulointerstitial nephritis in 16 (21.6%), acute tubulointerstitial nephritis in 11 (14.8%), diabetic nephropathy in 10 (13.5%), and thrombotic microangiopathy in 7 patients (9.4%). Higher viral load levels, diabetes mellitus, and age above 60 years were associated with kidney disease.<\/jats:p>\n<\/jats:sec>\n\nConclusion<\/jats:title>\nAsymptomatic HIV infection has a significant burden of kidney disease. Kidney biopsy is crucial for correct diagnosis and management. The absence of HIV associated nephropathy in proteinuric HIV patients is notable in this study.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/ijn_10_24","type":"journal-article","created":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T07:58:34Z","timestamp":1721807914000},"page":"623-629","update-policy":"http:\/\/dx.doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The High Burden of Asymptomatic Kidney Diseases in Individuals with HIV: A Prospective Study from a Tertiary Care Center in India"],"prefix":"10.25259","volume":"34","author":[{"given":"Kajaree","family":"Giri","sequence":"first","affiliation":[{"name":"Department of Nephrology, Osmania Medical College and Hospital, Hyderabad, Telangana, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manisha","family":"Sahay","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Osmania Medical College and Hospital, Hyderabad, Telangana, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiranmai","family":"Ismail","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Osmania Medical College and Hospital, Hyderabad, Telangana, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anuradha","family":"Kavadi","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Osmania Medical College and Hospital, Hyderabad, Telangana, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Rama","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Osmania Medical College and Hospital, Hyderabad, Telangana, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swarnalata","family":"Gowrishankar","sequence":"additional","affiliation":[{"name":"Department of Pathology, Apollo Hospitals, Hyderabad, Telangana, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2024,7,24]]},"reference":[{"key":"10.25259\/ijn_10_24\/ref-2","first-page":"197","article-title":"Renal disease in patients with AIDS: A clinicopathologic study","volume":"21","author":"Gardenswartz","year":"1984","journal-title":"Clin Nephrol"},{"key":"10.25259\/ijn_10_24\/ref-3","doi-asserted-by":"publisher","first-page":"1526","DOI":"10.1111\/j.1523-1755.2005.00232.x","article-title":"Incidence and etiology of acute renal failure among ambulatory HIV-infected patients","volume":"67","author":"Franceschini","year":"2005","journal-title":"Kidney Int"},{"key":"10.25259\/ijn_10_24\/ref-4","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1016\/j.ekir.2019.04.024","article-title":"DC cohort executive committee. 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