{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:59:10Z","timestamp":1787165950824,"version":"build-2736575974"},"reference-count":24,"publisher":"Scientific Scholar","content-domain":{"domain":["indianjnephrol.org"],"crossmark-restriction":true},"short-container-title":["IJN"],"abstract":"\n Background<\/jats:title>\n Continuous renal replacement therapy (CRRT) is used in hemodynamically unstable patients with acute kidney injury (AKI). Heparin, the most commonly used anticoagulant, has a significant bleeding risk and is associated with heparin-induced thrombocytopenia. Regional citrate anticoagulation is an alternative anticoagulation strategy in CRRT.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n A randomized controlled trial was conducted in the Intensive Care Unit over one year, from October 2020 to September 2021, in patients with AKI requiring CRRT. Fifty-two patients were randomized into two groups: group 1 received regional citrate anticoagulation, and group 2 received heparin anticoagulation.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n The mean age in group 1 was 50.46 years, while it was 49.35 years in group 2. The mean filter lifespan in group 1 was 45.11 hours, while in group 2, it was 26.11 hours and was statistically significant (P < 0.001). The mean effective delivered RRT dose was higher in group 1 (26 ml\/kg\/hour) compared to group 2 (24.23 ml\/kg\/hour), which was statistically significant (P < 0.001). Bleeding episodes were higher in group 2 than in group 1 (42.3% vs 11.5%), which was statistically significant (P = 0.027). The RCA group had various electrolyte and metabolic complications, but these were not statistically significant.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Regional citrate anticoagulation is better than heparin anticoagulation in terms of filter lifespan, effective delivered RRT dose, bleeding episodes, and metabolic complications.<\/jats:p>\n <\/jats:sec>","DOI":"10.25259\/ijn_195_23","type":"journal-article","created":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T02:29:10Z","timestamp":1722479350000},"page":"380-384","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy of Regional Citrate versus Heparin Anticoagulation in Continuous Renal Replacement Therapy"],"prefix":"10.25259","volume":"35","author":[{"given":"Gaurav","family":"Bhandari","sequence":"first","affiliation":[{"name":"Department of Nephrology, Sir Ganga Ram Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debarun","family":"Choudhury","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Sir Ganga Ram Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil Kumar","family":"Bhalla","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Sir Ganga Ram Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish","family":"Malik","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Sir Ganga Ram Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anurag","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Sir Ganga Ram Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinant","family":"Bhargava","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Sir Ganga Ram Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaibhav","family":"Tiwari","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Sir Ganga Ram Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiv","family":"Chadha","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Sir Ganga Ram Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashwani","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Sir Ganga Ram Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devinder Singh","family":"Rana","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Sir Ganga Ram Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2024,8,1]]},"reference":[{"key":"10.25259\/ijn_195_23\/ref-1","doi-asserted-by":"publisher","first-page":"1613","DOI":"10.1111\/j.1523-1755.2004.00927.x","article-title":"Program to improve care in acute renal disease. 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