{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:47:15Z","timestamp":1791362835209,"version":"4.3.1"},"reference-count":13,"publisher":"Scientific Scholar","content-domain":{"domain":["indianjnephrol.org"],"crossmark-restriction":true},"short-container-title":["IJN"],"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p>Children with nephrotic syndrome experience many side effects and frequent relapses when treated with steroids and other drugs. Mycophenolic acid (MPA) is one of the effective and least toxic drug for the treatment of nephrotic syndrome. This drug needs to be monitored for maximal efficacy and minimal toxicity. The therapeutic reference range for this drug is not established for the aforementioned patient population of Indian origin.<\/jats:p><\/jats:sec>\n<jats:sec><jats:title>Materials and Methods:<\/jats:title><jats:p>In this observational study, children with nephrotic syndrome on mycophenolate mofetil were followed up for a minimum duration of three months. Following this, their clinical status (relapse\/remission) was determined and the mycophenolate exposure was measured for over 12 hours.<\/jats:p><\/jats:sec>\n<jats:sec><jats:title>Results:<\/jats:title><jats:p>A total of 34 participants were included, with 17 (50%) in relapse. Median MPA Area under the curve over 12 hours (AUC0\u201312h) (36.5 \u00b5g\u00b7h\/ml) in the remission group differed significantly compared to that in the relapse group (17.2 \u00b5g\u00b7h\/ml).<\/jats:p><\/jats:sec>\n<jats:sec><jats:title>Conclusion:<\/jats:title><jats:p>Higher exposure to MPA AUC0\u201312h is associated with clinical remission of pediatric nephrotic syndrome.<\/jats:p><\/jats:sec>","DOI":"10.25259\/ijn_390_22","type":"journal-article","created":{"date-parts":[[2024,5,11]],"date-time":"2024-05-11T07:23:02Z","timestamp":1715412182000},"page":"323-327","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Exposure to Mycophenolic Acid and Its Clinical Response in an Indian Pediatric Population with Nephrotic Syndrome"],"prefix":"10.25259","volume":"34","author":[{"given":"R. V.","family":"Deepthi","sequence":"first","affiliation":[{"name":"Department of Pediatric Nephrology, Christian Medical College, Vellore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manjusha","family":"Arumadi","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology, Christian Medical College, Vellore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishnu","family":"Eriyat","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Clinical Pharmacology, Christian Medical College, Vellore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumith K.","family":"Mathew","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Clinical Pharmacology, Christian Medical College, Vellore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binu S.","family":"Mathew","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Clinical Pharmacology, Christian Medical College, Vellore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indira","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology, Christian Medical College, Vellore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ratna","family":"Prabha","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Clinical Pharmacology, Christian Medical College, Vellore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2024,5,11]]},"reference":[{"key":"10.25259\/ijn_390_22\/ref-1","doi-asserted-by":"publisher","first-page":"1376","DOI":"10.1007\/s00467-005-1964-z","article-title":"Mycophenolate mofetil therapy in frequently relapsing steroid-dependent and steroid-resistant nephrotic syndrome of childhood: Current status and future directions","volume":"20","author":"Moudgil","year":"2005","journal-title":"Pediatr Nephrol"},{"key":"10.25259\/ijn_390_22\/ref-2","doi-asserted-by":"publisher","first-page":"847","DOI":"10.2174\/092986710790712174","article-title":"Pediatric idiopathic nephrotic syndrome: Treatment strategies in steroid dependent and steroid resistant forms","volume":"17","author":"Ulinski","year":"2010","journal-title":"Curr Med Chem"},{"key":"10.25259\/ijn_390_22\/ref-3","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1016\/j.kint.2021.05.021","article-title":"KDIGO 2021 clinical practice guideline for the management of glomerular diseases","volume":"100","author":"Rovin","year":"2021","journal-title":"Kidney Int"},{"key":"10.25259\/ijn_390_22\/ref-4","first-page":"1250","volume-title":"Basic and Clinical Pharmacology","year":"2018","edition":"14th ed"},{"key":"10.25259\/ijn_390_22\/ref-5","doi-asserted-by":"publisher","first-page":"1689","DOI":"10.1681\/ASN.2012121200","article-title":"Mycophenolate mofetil versus cyclosporin a in children with frequently relapsing nephrotic syndrome","volume":"24","author":"Gellermann","year":"2013","journal-title":"JASN"},{"key":"10.25259\/ijn_390_22\/ref-6","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1159\/000445070","article-title":"The value of monitoring the serum concentration of mycophenolate mofetil in children with steroid-dependent\/frequent relapsing nephrotic syndrome","volume":"132","author":"Tong","year":"2016","journal-title":"Nephron"},{"key":"10.25259\/ijn_390_22\/ref-7","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1097\/FTD.0000000000000258","article-title":"Mycophenolate mofetil therapy in children with idiopathic nephrotic syndrome: Does therapeutic drug monitoring make a difference?","volume":"38","author":"Hackl","year":"2016","journal-title":"Ther Drug Monit"},{"key":"10.25259\/ijn_390_22\/ref-8","doi-asserted-by":"publisher","first-page":"1777","DOI":"10.2215\/CJN.00320116","article-title":"Mycophenolic acid pharmacokinetics and relapse in children with steroid\u2013dependent idiopathic nephrotic syndrome","volume":"11","author":"Tellier","year":"2016","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.25259\/ijn_390_22\/ref-9","doi-asserted-by":"publisher","first-page":"408","DOI":"10.4103\/0971-4065.174242","article-title":"Development and validation of limited sampling strategy equation for mycophenolate mofetil in children with systemic lupus erythematosus","volume":"26","author":"Prabha","year":"2016","journal-title":"Indian J Nephrol"},{"key":"10.25259\/ijn_390_22\/ref-10","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1007\/s00467-004-1571-4","article-title":"To what extent does the understanding of pharmacokinetics of mycophenolate mofetil influence its prescription","volume":"19","author":"Filler","year":"2004","journal-title":"Pediatr Nephrol"},{"key":"10.25259\/ijn_390_22\/ref-11","doi-asserted-by":"publisher","first-page":"i138","DOI":"10.1093\/ndt\/gfv065","article-title":"High interpatient variability in response to mycophenolic acid maintenance therapy in patients with ANCA-associated vasculitis","volume":"30","author":"Schaier","year":"2015","journal-title":"Nephrol Dial Transplant"},{"key":"10.25259\/ijn_390_22\/ref-12","doi-asserted-by":"publisher","first-page":"605060","DOI":"10.3389\/fphar.2020.605060","article-title":"PK\/PD study of mycophenolate mofetil in children with systemic lupus erythematosus to inform model-based precision dosing","volume":"11","author":"Chen","year":"2020","journal-title":"Front Pharmacol"},{"key":"10.25259\/ijn_390_22\/ref-13","doi-asserted-by":"publisher","first-page":"463","DOI":"10.2165\/11312600-000000000-00000","article-title":"Pharmacokinetic modelling of the plasma protein binding of mycophenolic acid in renal transplant recipients","volume":"48","author":"van Hest","year":"2009","journal-title":"Clin Pharmacokinet"}],"container-title":["Indian Journal of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/indianjnephrol.org\/exposure-to-mycophenolic-acid-and-its-clinical-response-in-an-indian-pediatric-population-with-nephrotic-syndrome\/","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/indianjnephrol.org\/exposure-to-mycophenolic-acid-and-its-clinical-response-in-an-indian-pediatric-population-with-nephrotic-syndrome\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,20]],"date-time":"2024-07-20T06:31:09Z","timestamp":1721457069000},"score":1,"resource":{"primary":{"URL":"https:\/\/indianjnephrol.org\/exposure-to-mycophenolic-acid-and-its-clinical-response-in-an-indian-pediatric-population-with-nephrotic-syndrome\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,11]]},"references-count":13,"alternative-id":["10.25259\/ijn_390_22"],"URL":"https:\/\/doi.org\/10.25259\/ijn_390_22","relation":{},"ISSN":["1998-3662","0971-4065"],"issn-type":[{"value":"1998-3662","type":"electronic"},{"value":"0971-4065","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5,11]]},"article-number":"323"}}