{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T21:15:45Z","timestamp":1776978945863,"version":"3.51.4"},"reference-count":5,"publisher":"Scientific Scholar","content-domain":{"domain":["indianjnephrol.org"],"crossmark-restriction":true},"short-container-title":["Indian J Nephrol"],"abstract":"<jats:p>Paroxysmal nocturnal haemoglobinuria (PNH), although a rare type of acquired hemolytic anemia, can be life-threatening if not diagnosed early. Kidney involvement in PNH varies from reversible acute kidney injury to irreversible chronic damage. Here, we report a case of recurrent acute kidney injury in a young male requiring renal replacement support. Repeated history of AKI with coombs negative hemolytic anemia led us to perform PNH profile after ruling out other causes. Although kidney involvement in PNH is not apparent, this case shows the importance of having a high index of suspicion which will help in preventing further episodes of AKI and thus, chronic kidney disease burden.<\/jats:p>","DOI":"10.25259\/ijn_437_23","type":"journal-article","created":{"date-parts":[[2024,6,29]],"date-time":"2024-06-29T10:58:20Z","timestamp":1719658700000},"page":"665-666","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["An Unusual Case of Relapsing and Remitting Acute Kidney Injury"],"prefix":"10.25259","volume":"34","author":[{"given":"Lavanya S R","family":"Bhat","sequence":"first","affiliation":[{"name":"Department of Nephrology, Nizams Institute of Medical Sciences, Hyderabad, Telangana, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gangadhar","family":"Taduri","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Nizams Institute of Medical Sciences, Hyderabad, Telangana, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swarnalatha","family":"Guditi","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Nizams Institute of Medical Sciences, Hyderabad, Telangana, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siddharth","family":"Herur","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Nizams Institute of Medical Sciences, Hyderabad, Telangana, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijay C.","family":"Bukka","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Nizams Institute of Medical Sciences, Hyderabad, Telangana, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prasanna","family":"Murugan","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Nizams Institute of Medical Sciences, Hyderabad, Telangana, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2024,6,29]]},"reference":[{"key":"10.25259\/ijn_437_23\/ref-1","doi-asserted-by":"publisher","first-page":"3782","DOI":"10.1182\/blood-2004-02-0645","article-title":"Transfer of glycosylphosphatidylinositol-anchored proteins to deficient cells after erythrocyte transfusion in paroxysmal nocturnal hemoglobinuria","volume":"104","author":"Sloand","year":"2004","journal-title":"Blood"},{"key":"10.25259\/ijn_437_23\/ref-2","doi-asserted-by":"publisher","first-page":"289","DOI":"10.4103\/0971-4065.205201","article-title":"Renal manifestations in paroxysmal nocturnal hemoglobinuria","volume":"27","author":"Ram","year":"2017","journal-title":"Indian J Nephrol"},{"key":"10.25259\/ijn_437_23\/ref-3","first-page":"72","article-title":"Recurrent acute kidney injury in tropics-epidemiology and outcomes","volume":"57","author":"Kaul","year":"2017","journal-title":"J Assoc Physicians India"},{"key":"10.25259\/ijn_437_23\/ref-4","doi-asserted-by":"publisher","first-page":"2567","DOI":"10.2215\/CJN.01120211","article-title":"Acute kidney injury episodes and chronic kidney disease risk in diabetes mellitus","volume":"6","author":"Thakar","year":"2011","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.25259\/ijn_437_23\/ref-5","doi-asserted-by":"publisher","first-page":"A14","DOI":"10.1053\/j.ajkd.2019.04.024","article-title":"Acute kidney injury, anemia, and recurrent dark red urine","volume":"74","author":"Falc\u00e3o","year":"2019","journal-title":"Am J Kidney Dis"}],"container-title":["Indian Journal of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/indianjnephrol.org\/an-unusual-case-of-relapsing-and-remitting-acute-kidney-injury\/","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/indianjnephrol.org\/an-unusual-case-of-relapsing-and-remitting-acute-kidney-injury\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T05:35:02Z","timestamp":1730180102000},"score":1,"resource":{"primary":{"URL":"https:\/\/indianjnephrol.org\/an-unusual-case-of-relapsing-and-remitting-acute-kidney-injury\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,29]]},"references-count":5,"alternative-id":["10.25259\/ijn_437_23"],"URL":"https:\/\/doi.org\/10.25259\/ijn_437_23","relation":{},"ISSN":["1998-3662","0971-4065"],"issn-type":[{"value":"1998-3662","type":"electronic"},{"value":"0971-4065","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6,29]]},"article-number":"665"}}